Basic Information:

  VIRBase ID:  

HHID00018271

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          SLCO4A1:  NM_016354     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	SLCO4A1
miRBase Accession/Entrez ID	MIMAT0026482	28231
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	OATP-E//OATP1//OATP4A1//OATPE//OATPRP1//POAT//SLC21A12

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLCO4A1	chr20:61287828-61287829(+) m6A CDS       24284625//24209618//25456834//22575960 chr20:61287963-61287964(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr20:61288019-61288020(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr20:61288458-61288459(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr20:61292466-61292467(+) m6A CDS       24284625//22575960 chr20:61292496-61292497(+) m6A CDS       24284625//22575960 chr20:61292507-61292508(+) m6A CDS       24284625//22575960 chr20:61292517-61292518(+) m6A CDS       24284625//22575960 chr20:61296308-61296309(+) m6A CDS       24284625//22575960 chr20:61297788-61297789(+) m6A CDS//exon       24284625 chr20:61298831-61298832(+) m6A exon//intron       24284625 chr20:61298907-61298908(+) m6A exon//intron       24284625 chr20:61299119-61299120(+) m6A CDS//exon//intron       24284625 chr20:61299162-61299163(+) m6A CDS//exon//intron       24284625 chr20:61301362-61301363(+) m6A exon//intron       24284625 chr20:61301432-61301433(+) m6A exon//intron       24209618 chr20:61301478-61301479(+) m6A exon//intron       24209618 chr20:61303176-61303177(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//22575960 chr20:61303300-61303301(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22575960//22608085 chr20:61303332-61303333(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22575960//22608085 chr20:61303431-61303432(+) m6A 3'UTR//exon//intron       24284625 chr20:61303455-61303456(+) m6A 3'UTR//exon//intron       24284625 chr20:61303525-61303526(+) m6A 3'UTR//intron       24284625 chr20:61316941-61316942(+) m6A exon       25456834 chr20:61317010-61317011(+) m6A exon       25456834 chr20:61317048-61317049(+) m6A exon       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	SLCO4A1	Chromatin HeLa-S3 cells|K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: SLCO4A1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).