Basic Information:

  VIRBase ID:  

HHID00018238

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          FBXO9:  NM_012347     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	FBXO9
miRBase Accession/Entrez ID	MIMAT0026482	26268
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	dJ341E18.2//FBX9//NY-REN-57//VCIA1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FBXO9	chr6:52955803(+) A-I      intronic chr6:52955832(+) A-I      intronic chr6:52951702(+) A-I      intronic chr6:52940171(+) A-I      intronic chr6:52940170(+) A-I      intronic chr6:52940169(+) A-I      intronic chr6:52940003(+) A-I      intronic chr6:52946255(+) A-I      intronic chr6:52951792(+) A-I      intronic chr6:52940174(+) A-I      intronic chr6:52940172(+) A-I      intronic chr6:52940203(+) A-I      intronic chr6:52955608(+) A-I      intronic chr6:52955546(+) A-I      intronic chr6:52954084(+) A-I      intronic chr6:52954072(+) A-I      intronic chr6:52954055(+) A-I      intronic chr6:52954028(+) A-I      intronic chr6:52956312(+) A-I      intronic chr6:52954014(+) A-I      intronic chr6:52956333(+) A-I      intronic chr6:52940818(+) A-I      intronic chr6:52955609(+) A-I      intronic chr6:52953800(+) A-I      intronic chr6:52952046(+) A-I      intronic chr6:52951956(+) A-I      intronic chr6:52951868(+) A-I      intronic chr6:52951817(+) A-I      intronic chr6:52951637(+) A-I      intronic chr6:52951611(+) A-I      intronic chr6:52951985(+) A-I      intronic chr6:52946150(+) A-I      intronic chr6:52933822(+) A-I      intronic chr6:52951703(+) A-I      intronic chr6:52940825(+) A-I      intronic chr6:52953526(+) A-I      intronic chr6:52940829(+) A-I      intronic chr6:52953496(+) A-I      intronic chr6:52951878(+) A-I      intronic chr6:52964431(+) A-I      3'UTR chr6:52953514(+) A-I      intronic chr6:52946746(+) A-I      intronic chr6:52951882(+) A-I      intronic chr6:52952084(+) A-I      intronic chr6:52940212(+) A-I      intronic chr6:52940816(+) A-I      intronic chr6:52952042(+) A-I      intronic chr6:52951705(+) A-I      intronic chr6:52951693(+) A-I      intronic chr6:52940185(+) A-I      intronic chr6:52951994(+) A-I      intronic chr6:52952100(+) A-I      intronic chr6:52956267(+) A-I      intronic chr6:52946612(+) A-I      intronic chr6:52951688(+) A-I      intronic chr6:52956332(+) A-I      intronic chr6:52955503(+) A-I      intronic chr6:52940211(+) A-I      intronic chr6:52943149(+) A-I      intronic chr6:52952025(+) A-I      intronic chr6:52952033(+) A-I      intronic chr6:52956271(+) A-I      intronic chr6:52953523(+) A-I      intronic chr6:52951691(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FBXO9	chr6:52940146(+) A-I intron -    21960545 chr6:52940149(+) A-I intron -    21960545 chr6:52965374(+) A-I intron -    21960545 chr6:52955786(+) A-G intron -    22484847 chr6:52933822(+) A-G intron -    22484847 chr6:52940803(+) A-G intron -    22484847 chr6:52940804(+) A-G intron -    22484847 chr6:52940816(+) A-G intron -    22484847 chr6:52946150(+) A-G intron -    22484847 chr6:52951882(+) A-G intron -    22484847 chr6:52952033(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FBXO9	chr6:52930461-52930462(+) m6A 5'UTR//exon//intron       22575960 chr6:52930485-52930486(+) m6A 5'UTR//exon//intron       22575960 chr6:52930499-52930500(+) m6A 5'UTR//exon//intron       22575960 chr6:52930507-52930508(+) m6A 5'UTR//exon//intron       22575960 chr6:52930850-52930851(+) m6A 5'UTR//intron       - chr6:52930894-52930895(+) m6A 5'UTR//intron       - chr6:52938316-52938317(+) m6A CDS//exon       24981863 chr6:52938389-52938390(+) m6A CDS//exon       24981863//27773535 chr6:52938412-52938413(+) m6A CDS//exon       24981863//27773535 chr6:52938418-52938419(+) m6A CDS//exon       24981863//27773535 chr6:52938528-52938529(+) m6A exon//intron       24981863 chr6:52938537-52938538(+) m6A exon//intron       24981863 chr6:52938543-52938544(+) m6A exon//intron       24981863 chr6:52941291-52941292(+) m6A CDS//exon       24981863 chr6:52941318-52941319(+) m6A CDS//exon       24981863 chr6:52960362-52960363(+) Cm CDS//exon       - chr6:52964180-52964181(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	FBXO9	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: FBXO9

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).