Basic Information:

  VIRBase ID:  

HHID00018201

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          LEMD3:  NM_014319     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	LEMD3
miRBase Accession/Entrez ID	MIMAT0026482	23592
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MAN1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LEMD3	chr12:65638569(+) A-I      intronic chr12:65638577(+) A-I      intronic chr12:65638456(+) A-I      intronic chr12:65639028(+) A-I      intronic chr12:65607106(+) A-I      intronic chr12:65625426(+) A-I      intronic chr12:65638473(+) A-I      intronic chr12:65625207(+) A-I      intronic chr12:65625203(+) A-I      intronic chr12:65638532(+) A-I      intronic chr12:65638542(+) A-I      intronic chr12:65625193(+) A-I      intronic chr12:65639047(+) A-I      intronic chr12:65606266(+) A-I      intronic chr12:65607242(+) A-I      intronic chr12:65638627(+) A-I      intronic chr12:65639118(+) A-I      intronic chr12:65638672(+) A-I      intronic chr12:65639199(+) A-I      intronic chr12:65638472(+) A-I      intronic chr12:65607085(+) A-I      intronic chr12:65638633(+) A-I      intronic chr12:65638610(+) A-I      intronic chr12:65639052(+) A-I      intronic chr12:65622367(+) A-I      intronic chr12:65638552(+) A-I      intronic chr12:65638715(+) A-I      intronic chr12:65638490(+) A-I      intronic chr12:65639126(+) A-I      intronic chr12:65638588(+) A-I      intronic chr12:65631935(+) A-I      intronic chr12:65638550(+) A-I      intronic chr12:65585675(+) A-I      intronic chr12:65638643(+) A-I      intronic chr12:65639050(+) A-I      intronic chr12:65638714(+) A-I      intronic chr12:65638470(+) A-I      intronic chr12:65638584(+) A-I      intronic chr12:65625359(+) A-I      intronic chr12:65637547(+) A-I      intronic chr12:65638961(+) A-I      intronic chr12:65638549(+) A-I      intronic chr12:65631847(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	LEMD3	chr12:65566608(+) T-C intron -    22484847 chr12:65622367(+) A-G intron -    22484847 chr12:65622398(+) G-A intron -    22484847 chr12:65638549(+) A-G intron -    22484847 chr12:65638552(+) A-G intron -    22484847 chr12:65639050(+) A-G intron -    22484847 chr12:65639052(+) A-G intron -    22484847 chr12:65639126(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LEMD3	chr12:65563360-65563361(+) m6A 5'UTR       24284625//24981863//22608085 chr12:65563462-65563463(+) m6A CDS//exon       24284625//24981863//22608085 chr12:65563508-65563509(+) m1A CDS//exon       26863196 chr12:65563569-65563570(+) m6A CDS//exon       24284625//24209618//24981863//22608085 chr12:65563615-65563616(+) m6A CDS//exon       24284625//24209618//24981863//22608085 chr12:65563682-65563683(+) m6A CDS//exon       24209618//25456834//24981863//22575960//22608085 chr12:65563830-65563831(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr12:65563857-65563858(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr12:65564000-65564001(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr12:65564067-65564068(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr12:65564075-65564076(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr12:65564102-65564103(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr12:65564145-65564146(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr12:65564154-65564155(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr12:65564194-65564195(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr12:65564240-65564241(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr12:65564297-65564298(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr12:65564320-65564321(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr12:65564361-65564362(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr12:65564373-65564374(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr12:65564424-65564425(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr12:65564464-65564465(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:65564502-65564503(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:65564540-65564541(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:65564577-65564578(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:65564691-65564692(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr12:65564704-65564705(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:65564719-65564720(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:65564731-65564732(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:65564842-65564843(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:65564867-65564868(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:65564890-65564891(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:65604711-65604712(+) m6A CDS//exon       24209618//25456834//24981863//27773535//22575960//22608085 chr12:65604725-65604726(+) m6A CDS       24209618//25456834//24981863//27773535//22575960//22608085 chr12:65609768-65609769(+) m6A CDS       24209618//24981863//27773535//22608085 chr12:65609781-65609782(+) m6A CDS       24209618//24981863//27773535//22608085 chr12:65640038-65640039(+) m6A CDS//exon       24981863//22608085 chr12:65640046-65640047(+) m6A CDS//exon       24981863//22608085 chr12:65640072-65640073(+) m6A CDS//exon       24981863//22608085 chr12:65640128-65640129(+) m6A 3'UTR//exon       24981863//22608085 chr12:65640354-65640355(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	LEMD3	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: LEMD3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).