Basic Information:

  VIRBase ID:  

HHID00018197

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          SLC39A14:  NM_001135153     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	SLC39A14
miRBase Accession/Entrez ID	MIMAT0026482	23516
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	cig19//HCIN//HMNDYT2//LZT-Hs4//NET34//ZIP14

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC39A14	chr8:22238315(+) A-I      intronic chr8:22237362(+) A-I      intronic chr8:22237327(+) A-I      intronic chr8:22237258(+) A-I      intronic chr8:22237197(+) A-I      intronic chr8:22237189(+) A-I      intronic chr8:22230682(+) A-I      intronic chr8:22238221(+) A-I      intronic chr8:22237173(+) A-I      intronic chr8:22234220(+) A-I      intronic chr8:22234207(+) A-I      intronic chr8:22261054(+) A-I      intronic chr8:22261174(+) A-I      intronic chr8:22271343(+) A-I      intronic chr8:22271331(+) A-I      intronic chr8:22270396(+) A-I      intronic chr8:22270372(+) A-I      intronic chr8:22270363(+) A-I      intronic chr8:22270328(+) A-I      intronic chr8:22270316(+) A-I      intronic chr8:22233814(+) A-I      intronic chr8:22233811(+) A-I      intronic chr8:22233717(+) A-I      intronic chr8:22233281(+) A-I      intronic chr8:22233183(+) A-I      intronic chr8:22233099(+) A-I      intronic chr8:22233098(+) A-I      intronic chr8:22232535(+) A-I      intronic chr8:22231372(+) A-I      intronic chr8:22231336(+) A-I      intronic chr8:22270281(+) A-I      intronic chr8:22270273(+) A-I      intronic chr8:22270271(+) A-I      intronic chr8:22270261(+) A-I      intronic chr8:22238359(+) A-I      intronic chr8:22261272(+) A-I      intronic chr8:22261324(+) A-I      intronic chr8:22270256(+) A-I      intronic chr8:22266661(+) A-I      intronic chr8:22270255(+) A-I      intronic chr8:22270243(+) A-I      intronic chr8:22230697(+) A-I      intronic chr8:22270207(+) A-I      intronic chr8:22238913(+) A-I      intronic chr8:22230688(+) A-I      intronic chr8:22230687(+) A-I      intronic chr8:22276454(+) A-I      intronic chr8:22276435(+) A-I      intronic chr8:22271429(+) A-I      intronic chr8:22230552(+) A-I      intronic chr8:22287833(+) A-I      intronic chr8:22287816(+) A-I      intronic chr8:22287815(+) A-I      intronic chr8:22282457(+) A-I      intronic chr8:22282454(+) A-I      intronic chr8:22239495(+) A-I      intronic chr8:22239498(+) A-I      intronic chr8:22239507(+) A-I      intronic chr8:22239534(+) A-I      intronic chr8:22239610(+) A-I      intronic chr8:22240505(+) A-I      intronic chr8:22241999(+) A-I      intronic chr8:22243252(+) A-I      intronic chr8:22244530(+) A-I      intronic chr8:22244535(+) A-I      intronic chr8:22252555(+) A-I      intronic chr8:22252623(+) A-I      intronic chr8:22252626(+) A-I      intronic chr8:22252627(+) A-I      intronic chr8:22253727(+) A-I      intronic chr8:22253730(+) A-I      intronic chr8:22280905(+) A-I      intronic chr8:22280478(+) A-I      intronic chr8:22276894(+) A-I      intronic chr8:22276541(+) A-I      intronic chr8:22271527(+) A-I      intronic chr8:22271477(+) A-I      intronic chr8:22271460(+) A-I      intronic chr8:22271438(+) A-I      intronic chr8:22253738(+) A-I      intronic chr8:22253760(+) A-I      intronic chr8:22253819(+) A-I      intronic chr8:22253864(+) A-I      intronic chr8:22254970(+) A-I      intronic chr8:22260849(+) A-I      intronic chr8:22276467(+) A-I      intronic chr8:22276462(+) A-I      intronic chr8:22275515(+) A-I      intronic chr8:22270305(+) A-I      intronic chr8:22270304(+) A-I      intronic chr8:22238355(+) A-I      intronic chr8:22238316(+) A-I      intronic chr8:22237292(+) A-I      intronic chr8:22291487(+) A-I      Syn:Arg->Arg chr8:22245410(+) A-I      intronic chr8:22270323(+) A-I      intronic chr8:22244641(+) A-I      intronic chr8:22238864(+) A-I      intronic chr8:22234138(+) A-I      intronic chr8:22244523(+) A-I      intronic chr8:22289648(+) A-I      intronic chr8:22271472(+) A-I      intronic chr8:22237348(+) A-I      intronic chr8:22238411(+) A-I      intronic chr8:22280611(+) A-I      intronic chr8:22265495(+) A-I      intronic chr8:22264954(+) A-I      intronic chr8:22230613(+) A-I      intronic chr8:22240048(+) A-I      intronic chr8:22252695(+) A-I      intronic chr8:22270371(+) A-I      intronic chr8:22226150(+) A-I      intronic chr8:22239494(+) A-I      intronic chr8:22238404(+) A-I      intronic chr8:22265408(+) A-I      intronic chr8:22238307(+) A-I      intronic chr8:22270201(+) A-I      intronic chr8:22255036(+) A-I      intronic chr8:22271451(+) A-I      intronic chr8:22237321(+) A-I      intronic chr8:22237284(+) A-I      intronic chr8:22240251(+) A-I      intronic chr8:22233896(+) A-I      intronic chr8:22240110(+) A-I      intronic chr8:22271515(+) A-I      intronic chr8:22271368(+) A-I      intronic chr8:22243277(+) A-I      intronic chr8:22270360(+) A-I      intronic chr8:22261682(+) A-I      intronic chr8:22286530(+) A-I      intronic chr8:22276144(+) A-I      intronic chr8:22233709(+) A-I      intronic chr8:22244661(+) A-I      intronic chr8:22286632(+) A-I      intronic chr8:22240259(+) A-I      intronic chr8:22234270(+) A-I      intronic chr8:22253704(+) A-I      intronic chr8:22276431(+) A-I      intronic chr8:22253726(+) A-I      intronic chr8:22234311(+) A-I      intronic chr8:22271540(+) A-I      intronic chr8:22276114(+) A-I      intronic chr8:22232442(+) A-I      intronic chr8:22234131(+) A-I      intronic chr8:22270310(+) A-I      intronic chr8:22253720(+) A-I      intronic chr8:22270336(+) A-I      intronic chr8:22243308(+) A-I      intronic chr8:22240278(+) A-I      intronic chr8:22271447(+) A-I      intronic chr8:22233879(+) A-I      intronic chr8:22270314(+) A-I      intronic chr8:22238379(+) A-I      intronic chr8:22286697(+) A-I      intronic chr8:22265456(+) A-I      intronic chr8:22244571(+) A-I      intronic chr8:22286628(+) A-I      intronic chr8:22286674(+) A-I      intronic chr8:22286619(+) A-I      intronic chr8:22281448(+) A-I      intronic chr8:22265000(+) A-I      intronic chr8:22244056(+) A-I      intronic chr8:22271362(+) A-I      intronic chr8:22271367(+) A-I      intronic chr8:22261818(+) A-I      intronic chr8:22237295(+) A-I      intronic chr8:22270392(+) A-I      intronic chr8:22270199(+) A-I      intronic chr8:22239478(+) A-I      intronic chr8:22261266(+) A-I      intronic chr8:22285653(+) A-I      intronic chr8:22244520(+) A-I      intronic chr8:22270228(+) A-I      intronic chr8:22271417(+) A-I      intronic chr8:22237286(+) A-I      intronic chr8:22230570(+) A-I      intronic chr8:22234200(+) A-I      intronic chr8:22234215(+) A-I      intronic chr8:22234137(+) A-I      intronic chr8:22233788(+) A-I      intronic chr8:22242201(+) A-I      intronic chr8:22286670(+) A-I      intronic chr8:22233186(+) A-I      intronic chr8:22233785(+) A-I      intronic chr8:22255056(+) A-I      intronic chr8:22276445(+) A-I      intronic chr8:22234135(+) A-I      intronic chr8:22270337(+) A-I      intronic chr8:22237331(+) A-I      intronic chr8:22270401(+) A-I      intronic chr8:22239493(+) A-I      intronic chr8:22237194(+) A-I      intronic chr8:22286625(+) A-I      intronic chr8:22233784(+) A-I      intronic chr8:22238959(+) A-I      intronic chr8:22238410(+) A-I      intronic chr8:22237322(+) A-I      intronic chr8:22238364(+) A-I      intronic chr8:22232290(+) A-I      intronic chr8:22240253(+) A-I      intronic chr8:22271427(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLC39A14	chr8:22232290(+) A-G intron -    22484847 chr8:22232359(+) A-G intron -    22484847 chr8:22232442(+) A-G intron -    22484847 chr8:22233186(+) A-G intron -    22484847 chr8:22233784(+) A-G intron -    22484847 chr8:22233785(+) A-G intron -    22484847 chr8:22233788(+) A-G intron -    22484847 chr8:22234131(+) A-G intron -    22484847 chr8:22234135(+) A-G intron -    22484847 chr8:22234137(+) A-G intron -    22484847 chr8:22234138(+) A-G intron -    22484847 chr8:22234200(+) A-G intron -    22484847 chr8:22234311(+) A-G intron -    22484847 chr8:22237321(+) A-G intron -    22484847 chr8:22238200(+) A-T intron -    22484847 chr8:22238201(+) A-T intron -    22484847 chr8:22238267(+) A-G intron -    22484847 chr8:22238302(+) A-G intron -    22484847 chr8:22238307(+) A-G intron -    22484847 chr8:22238364(+) A-G intron -    22484847 chr8:22239478(+) A-G intron -    22484847 chr8:22239493(+) A-G intron -    22484847 chr8:22239494(+) A-G intron -    22484847 chr8:22239637(+) A-G intron -    22484847 chr8:22243248(+) A-G intron -    22484847 chr8:22252695(+) A-G intron -    22484847 chr8:22253704(+) A-G intron -    22484847 chr8:22253720(+) A-G intron -    22484847 chr8:22253726(+) A-G intron -    22484847 chr8:22261269(+) A-G intron -    22484847 chr8:22270199(+) A-G intron -    22484847 chr8:22271368(+) A-G intron -    22484847 chr8:22276145(+) A-G intron -    22484847 chr8:22286619(+) A-G intron -    22484847 chr8:22286628(+) A-G intron -    22484847 chr8:22286633(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC39A14	chr8:22262333-22262334(+) Y CDS       26075521 chr8:22277137-22277138(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr8:22277192-22277193(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr8:22277233-22277234(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr8:22277275-22277276(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr8:22277320-22277321(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr8:22277330-22277331(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr8:22277461-22277462(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr8:22277481-22277482(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr8:22277525-22277526(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr8:22277654-22277655(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr8:22277678-22277679(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr8:22277685-22277686(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr8:22277746-22277747(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr8:22277759-22277760(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr8:22277817-22277818(+) m6A 3'UTR//intron       26404942//22575960//22608085 chr8:22278055-22278056(+) m6A 3'UTR//intron       24981863 chr8:22278099-22278100(+) m6A 3'UTR//intron       24981863 chr8:22278119-22278120(+) m6A 3'UTR//intron       24981863 chr8:22278128-22278129(+) m6A 3'UTR//intron       24981863 chr8:22278208-22278209(+) m6A 3'UTR//intron       26404942 chr8:22278313-22278314(+) m6A 3'UTR//intron       26404942 chr8:22280137-22280138(+) m6A 3'UTR//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	SLC39A14	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: SLC39A14

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).