Basic Information:

  VIRBase ID:  

HHID00018183

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          ARHGEF12:  NM_001198665     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	ARHGEF12
miRBase Accession/Entrez ID	MIMAT0026482	23365
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LARG//PRO2792

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ARHGEF12	chr11:120221879(+) A-I      intronic chr11:120304409(+) A-I      intronic chr11:120304447(+) A-I      intronic chr11:120304431(+) A-I      intronic chr11:120304445(+) A-I      intronic chr11:120265557(+) A-I      intronic chr11:120221852(+) A-I      intronic chr11:120304432(+) A-I      intronic chr11:120221873(+) A-I      intronic chr11:120320227(+) A-I      intronic chr11:120320221(+) A-I      intronic chr11:120228436(+) A-I      intronic chr11:120228421(+) A-I      intronic chr11:120228420(+) A-I      intronic chr11:120228418(+) A-I      intronic chr11:120228310(+) A-I      intronic chr11:120228302(+) A-I      intronic chr11:120222445(+) A-I      intronic chr11:120222443(+) A-I      intronic chr11:120221984(+) A-I      intronic chr11:120221881(+) A-I      intronic chr11:120221880(+) A-I      intronic chr11:120221851(+) A-I      intronic chr11:120296125(+) A-I      intronic chr11:120239869(+) A-I      intronic chr11:120239052(+) A-I      intronic chr11:120304588(+) A-I      intronic chr11:120316336(+) A-I      intronic chr11:120320365(+) A-I      intronic chr11:120298156(+) A-I      intronic chr11:120265125(+) A-I      intronic chr11:120320841(+) A-I      intronic chr11:120237605(+) A-I      intronic chr11:120259785(+) A-I      intronic chr11:120239977(+) A-I      intronic chr11:120297792(+) A-I      intronic chr11:120231341(+) A-I      intronic chr11:120265566(+) A-I      intronic chr11:120237129(+) A-I      intronic chr11:120238494(+) A-I      intronic chr11:120239032(+) A-I      intronic chr11:120309604(+) A-I      intronic chr11:120253594(+) A-I      intronic chr11:120214773(+) A-I      intronic chr11:120228365(+) A-I      intronic chr11:120238204(+) A-I      intronic chr11:120265088(+) A-I      intronic chr11:120320261(+) A-I      intronic chr11:120321952(+) A-I      intronic chr11:120296198(+) A-I      intronic chr11:120298310(+) A-I      intronic chr11:120298150(+) A-I      intronic chr11:120298178(+) A-I      intronic chr11:120265675(+) A-I      intronic chr11:120253754(+) A-I      intronic chr11:120297817(+) A-I      intronic chr11:120239086(+) A-I      intronic chr11:120265707(+) A-I      intronic chr11:120265708(+) A-I      intronic chr11:120221077(+) A-I      intronic chr11:120231337(+) A-I      intronic chr11:120298306(+) A-I      intronic chr11:120265646(+) A-I      intronic chr11:120352538(+) A-I      intronic chr11:120352533(+) A-I      intronic chr11:120328088(+) A-I      intronic chr11:120328079(+) A-I      intronic chr11:120328076(+) A-I      intronic chr11:120322122(+) A-I      intronic chr11:120322029(+) A-I      intronic chr11:120321043(+) A-I      intronic chr11:120320962(+) A-I      intronic chr11:120320328(+) A-I      intronic chr11:120320293(+) A-I      intronic chr11:120320246(+) A-I      intronic chr11:120320226(+) A-I      intronic chr11:120320198(+) A-I      intronic chr11:120320192(+) A-I      intronic chr11:120320181(+) A-I      intronic chr11:120320155(+) A-I      intronic chr11:120306293(+) A-I      intronic chr11:120306288(+) A-I      intronic chr11:120306287(+) A-I      intronic chr11:120298216(+) A-I      intronic chr11:120298165(+) A-I      intronic chr11:120297868(+) A-I      intronic chr11:120297787(+) A-I      intronic chr11:120297666(+) A-I      intronic chr11:120296286(+) A-I      intronic chr11:120265753(+) A-I      intronic chr11:120265571(+) A-I      intronic chr11:120265503(+) A-I      intronic chr11:120265143(+) A-I      intronic chr11:120265140(+) A-I      intronic chr11:120265021(+) A-I      intronic chr11:120259646(+) A-I      intronic chr11:120259615(+) A-I      intronic chr11:120244666(+) A-I      intronic chr11:120244646(+) A-I      intronic chr11:120242077(+) A-I      intronic chr11:120240035(+) A-I      intronic chr11:120240018(+) A-I      intronic chr11:120240010(+) A-I      intronic chr11:120239950(+) A-I      intronic chr11:120239942(+) A-I      intronic chr11:120239938(+) A-I      intronic chr11:120239114(+) A-I      intronic chr11:120239015(+) A-I      intronic chr11:120238979(+) A-I      intronic chr11:120238554(+) A-I      intronic chr11:120238550(+) A-I      intronic chr11:120238451(+) A-I      intronic chr11:120238431(+) A-I      intronic chr11:120238128(+) A-I      intronic chr11:120237572(+) A-I      intronic chr11:120237571(+) A-I      intronic chr11:120237559(+) A-I      intronic chr11:120237528(+) A-I      intronic chr11:120236836(+) A-I      intronic chr11:120236819(+) A-I      intronic chr11:120236816(+) A-I      intronic chr11:120236814(+) A-I      intronic chr11:120236789(+) A-I      intronic chr11:120236752(+) A-I      intronic chr11:120233688(+) A-I      intronic chr11:120233632(+) A-I      intronic chr11:120233631(+) A-I      intronic chr11:120233560(+) A-I      intronic chr11:120233555(+) A-I      intronic chr11:120221926(+) A-I      intronic chr11:120233554(+) A-I      intronic chr11:120231241(+) A-I      intronic chr11:120231231(+) A-I      intronic chr11:120231126(+) A-I      intronic chr11:120230062(+) A-I      intronic chr11:120338219(+) A-I      intronic chr11:120230971(+) A-I      intronic chr11:120264960(+) A-I      intronic chr11:120304516(+) A-I      intronic chr11:120238997(+) A-I      intronic chr11:120301878(+) A-I      intronic chr11:120265581(+) A-I      intronic chr11:120264947(+) A-I      intronic chr11:120296123(+) A-I      intronic chr11:120296097(+) A-I      intronic chr11:120238425(+) A-I      intronic chr11:120234753(+) A-I      intronic chr11:120238424(+) A-I      intronic chr11:120238335(+) A-I      intronic chr11:120273961(+) A-I      intronic chr11:120320258(+) A-I      intronic chr11:120231125(+) A-I      intronic chr11:120320378(+) A-I      intronic chr11:120298157(+) A-I      intronic chr11:120298119(+) A-I      intronic chr11:120298391(+) A-I      intronic chr11:120214890(+) A-I      intronic chr11:120352733(+) A-I      intronic chr11:120234292(+) A-I      intronic chr11:120231374(+) A-I      intronic chr11:120239087(+) A-I      intronic chr11:120298179(+) A-I      intronic chr11:120240112(+) A-I      intronic chr11:120265114(+) A-I      intronic chr11:120298211(+) A-I      intronic chr11:120304654(+) A-I      intronic chr11:120297784(+) A-I      intronic chr11:120353200(+) A-I      intronic chr11:120238560(+) A-I      intronic chr11:120296204(+) A-I      intronic chr11:120265639(+) A-I      intronic chr11:120274055(+) A-I      intronic chr11:120259649(+) A-I      intronic chr11:120265170(+) A-I      intronic chr11:120265729(+) A-I      intronic chr11:120238518(+) A-I      intronic chr11:120298302(+) A-I      intronic chr11:120230027(+) A-I      intronic chr11:120265511(+) A-I      intronic chr11:120236718(+) A-I      intronic chr11:120320297(+) A-I      intronic chr11:120265529(+) A-I      intronic chr11:120320825(+) A-I      intronic chr11:120296258(+) A-I      intronic chr11:120216157(+) A-I      intronic chr11:120221871(+) A-I      intronic chr11:120297679(+) A-I      intronic chr11:120320193(+) A-I      intronic chr11:120320830(+) A-I      intronic chr11:120230896(+) A-I      intronic chr11:120344245(+) A-I      intronic chr11:120238552(+) A-I      intronic chr11:120338221(+) A-I      intronic chr11:120235686(+) A-I      intronic chr11:120231214(+) A-I      intronic chr11:120259763(+) A-I      intronic chr11:120238464(+) A-I      intronic chr11:120264999(+) A-I      intronic chr11:120231364(+) A-I      intronic chr11:120304547(+) A-I      intronic chr11:120227069(+) A-I      intronic chr11:120239907(+) A-I      intronic chr11:120226295(+) A-I      intronic chr11:120235731(+) A-I      intronic chr11:120309836(+) A-I      intronic chr11:120230914(+) A-I      intronic chr11:120214876(+) A-I      intronic chr11:120216265(+) A-I      intronic chr11:120238347(+) A-I      intronic chr11:120352517(+) A-I      intronic chr11:120237522(+) A-I      intronic chr11:120354404(+) A-I      intronic chr11:120320898(+) A-I      intronic chr11:120226309(+) A-I      intronic chr11:120322027(+) A-I      intronic chr11:120298241(+) A-I      intronic chr11:120222038(+) A-I      intronic chr11:120235622(+) A-I      intronic chr11:120231244(+) A-I      intronic chr11:120265638(+) A-I      intronic chr11:120240038(+) A-I      intronic chr11:120231219(+) A-I      intronic chr11:120240076(+) A-I      intronic chr11:120274064(+) A-I      intronic chr11:120237483(+) A-I      intronic chr11:120215964(+) A-I      intronic chr11:120237578(+) A-I      intronic chr11:120320368(+) A-I      intronic chr11:120226289(+) A-I      intronic chr11:120344253(+) A-I      intronic chr11:120265046(+) A-I      intronic chr11:120238214(+) A-I      intronic chr11:120259711(+) A-I      intronic chr11:120237523(+) A-I      intronic chr11:120298269(+) A-I      intronic chr11:120239955(+) A-I      intronic chr11:120354074(+) A-I      intronic chr11:120265565(+) A-I      intronic chr11:120238498(+) A-I      intronic chr11:120230059(+) A-I      intronic chr11:120235635(+) A-I      intronic chr11:120214924(+) A-I      intronic chr11:120298210(+) A-I      intronic chr11:120230140(+) A-I      intronic chr11:120297796(+) A-I      intronic chr11:120238530(+) A-I      intronic chr11:120214925(+) A-I      intronic chr11:120304436(+) A-I      intronic chr11:120214881(+) A-I      intronic chr11:120273960(+) A-I      intronic chr11:120231133(+) A-I      intronic chr11:120230037(+) A-I      intronic chr11:120265520(+) A-I      intronic chr11:120295886(+) A-I      intronic chr11:120229957(+) A-I      intronic chr11:120237102(+) A-I      intronic chr11:120227803(+) A-I      intronic chr11:120265059(+) A-I      intronic chr11:120265645(+) A-I      intronic chr11:120316457(+) A-I      intronic chr11:120320287(+) A-I      intronic chr11:120230151(+) A-I      intronic chr11:120253733(+) A-I      intronic chr11:120231195(+) A-I      intronic chr11:120222309(+) A-I      intronic chr11:120297837(+) A-I      intronic chr11:120253696(+) A-I      intronic chr11:120253701(+) A-I      intronic chr11:120320245(+) A-I      intronic chr11:120222380(+) A-I      intronic chr11:120238989(+) A-I      intronic chr11:120238531(+) A-I      intronic chr11:120230972(+) A-I      intronic chr11:120227124(+) A-I      intronic chr11:120239072(+) A-I      intronic chr11:120265754(+) A-I      intronic chr11:120304410(+) A-I      intronic chr11:120221929(+) A-I      intronic chr11:120231301(+) A-I      intronic chr11:120237548(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ARHGEF12	chr11:120214876(+) A-I intron -    15342557 chr11:120214881(+) A-I intron -    15342557 chr11:120214890(+) A-I intron -    15342557 chr11:120214924(+) A-I intron -    15342557 chr11:120214925(+) A-I intron -    15342557 chr11:120215964(+) A-I intron -    15342557 chr11:120297784(+) A-I intron -    15258596 chr11:120297792(+) A-I intron -    15258596 chr11:120298157(+) A-I intron -    15258596 chr11:120265646(+) A-G intron -    22484847 chr11:120296123(+) A-G intron -    22484847 chr11:120297679(+) A-G intron -    22484847 chr11:120297837(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARHGEF12	chr11:120207719-120207720(+) m6A 5'UTR       - chr11:120207839-120207840(+) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120207932-120207933(+) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120276841-120276842(+) m6A 5'UTR//CDS//exon       - chr11:120278463-120278464(+) m6A 5'UTR//CDS//exon       - chr11:120278537-120278538(+) m6A exon//intron       - chr11:120300210-120300211(+) m6A CDS//exon       24981863 chr11:120300444-120300445(+) m6A CDS//exon       24981863 chr11:120300488-120300489(+) m6A CDS//exon       24981863 chr11:120302505-120302506(+) m6A CDS//exon       22575960 chr11:120302516-120302517(+) m6A CDS//exon       22575960 chr11:120302542-120302543(+) m6A CDS//exon       22575960 chr11:120302569-120302570(+) m6A CDS//exon       - chr11:120308059-120308060(+) m6A CDS//exon       - chr11:120308076-120308077(+) m6A CDS//exon       - chr11:120317674-120317675(+) m6A CDS//exon       24981863 chr11:120317704-120317705(+) m6A CDS//exon       24981863 chr11:120317721-120317722(+) m6A CDS//exon       24981863 chr11:120317727-120317728(+) m6A CDS//exon       24981863 chr11:120317753-120317754(+) m6A CDS//exon       24981863 chr11:120317764-120317765(+) m6A CDS//exon       24981863 chr11:120319207-120319208(+) m6A exon//intron       24981863 chr11:120319232-120319233(+) m6A exon//intron       24981863 chr11:120319240-120319241(+) m6A exon//intron       24981863 chr11:120319251-120319252(+) m6A exon//intron       24981863 chr11:120319885-120319886(+) m6A CDS//exon       24981863 chr11:120319897-120319898(+) m6A CDS//exon       24981863 chr11:120322293-120322294(+) m6A CDS//exon       22575960 chr11:120322301-120322302(+) m6A CDS//exon       22575960 chr11:120322342-120322343(+) m6A CDS//exon       22575960 chr11:120340089-120340090(+) m6A CDS//exon       24981863 chr11:120343787-120343788(+) Y CDS//exon       26075521 chr11:120348904-120348905(+) m6A CDS//exon       - chr11:120348970-120348971(+) m6A CDS//exon       24981863 chr11:120348985-120348986(+) m6A CDS//exon       - chr11:120348993-120348994(+) Cm CDS//exon       - chr11:120349001-120349002(+) m6A CDS//exon       - chr11:120350731-120350732(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350757-120350758(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350778-120350779(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350797-120350798(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350834-120350835(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350850-120350851(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350856-120350857(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350889-120350890(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350927-120350928(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350971-120350972(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120351971-120351972(+) m6A CDS       24284625//24209618//24981863//22608085 chr11:120355902-120355903(+) m6A 3'UTR       24284625 chr11:120356210-120356211(+) m6A 3'UTR       24981863 chr11:120356744-120356745(+) m6A 3'UTR       24981863 chr11:120359567-120359568(+) m6A 3'UTR       27773535 chr11:120359649-120359650(+) m6A 3'UTR       27773535 chr11:120359671-120359672(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	ARHGEF12	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: ARHGEF12

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).