Basic Information:

  VIRBase ID:  

HHID00018124

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          RER1:  NM_007033     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	RER1
miRBase Accession/Entrez ID	MIMAT0026482	11079
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RER1	chr1:2323367-2323368(+) m6A 5'UTR//exon       24981863//22575960 chr1:2325747-2325748(+) m6A 5'UTR//intron       - chr1:2326477-2326478(+) m6A 5'UTR//intron       - chr1:2326484-2326485(+) m6A 5'UTR//intron       - chr1:2326507-2326508(+) m6A 5'UTR//intron       - chr1:2326567-2326568(+) m6A 5'UTR//intron       - chr1:2326737-2326738(+) m6A 5'UTR//intron       - chr1:2326753-2326754(+) m6A 5'UTR//intron       - chr1:2326778-2326779(+) m6A 5'UTR//intron       - chr1:2326785-2326786(+) m6A 5'UTR//intron       - chr1:2326792-2326793(+) m6A 5'UTR//intron       - chr1:2326808-2326809(+) m6A 5'UTR//intron       - chr1:2326829-2326830(+) m6A 5'UTR//intron       - chr1:2326870-2326871(+) m6A 5'UTR//intron       - chr1:2334570-2334571(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//27773535//22575960//22608085 chr1:2334597-2334598(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:2334725-2334726(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr1:2334737-2334738(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr1:2335012-2335013(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr1:2335124-2335125(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr1:2335450-2335451(+) m6A 3'UTR       27773535 chr1:2335466-2335467(+) m6A 3'UTR       27773535 chr1:2335527-2335528(+) m6A 3'UTR       27773535 chr1:2335553-2335554(+) m6A 3'UTR       27773535 chr1:2335792-2335793(+) m6A 3'UTR       24981863 chr1:2335809-2335810(+) m6A 3'UTR       24981863 chr1:2335816-2335817(+) m6A 3'UTR       24981863 chr1:2335920-2335921(+) m6A 3'UTR       24284625//24981863 chr1:2336100-2336101(+) m6A 3'UTR       25456834//27773536//22608085 chr1:2336108-2336109(+) m6A 3'UTR       25456834//27773536//22608085 chr1:2336295-2336296(+) m6A 3'UTR       24981863//27773535 chr1:2336328-2336329(+) m6A 3'UTR       24981863//27773535 chr1:2336336-2336337(+) m6A 3'UTR       24981863//27773535 chr1:2336384-2336385(+) m6A 3'UTR       24284625//24981863//27773535 chr1:2336476-2336477(+) m6A 3'UTR       24284625//27773535 chr1:2336510-2336511(+) m6A 3'UTR       24284625//27773535 chr1:2336557-2336558(+) m6A 3'UTR       24284625//27773535//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	RER1	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: RER1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).