Basic Information:

  VIRBase ID:  

HHID00018110

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          WDR3:  NM_006784     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	WDR3
miRBase Accession/Entrez ID	MIMAT0026482	10885
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DIP2//UTP12

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WDR3	chr1:118477286-118477287(+) m6A 3'UTR//CDS//exon       - chr1:118495233-118495234(+) m6A CDS       24981863 chr1:118495246-118495247(+) m6A CDS       24209618//24981863 chr1:118495608-118495609(+) m6A CDS       24209618//24981863//27773535 chr1:118496110-118496111(+) m6A CDS       24209618//24981863//27773535 chr1:118496143-118496144(+) m6A CDS       24209618//24981863//27773535 chr1:118496152-118496153(+) m6A CDS       24209618//24981863//27773535 chr1:118496671-118496672(+) m6A CDS       24981863 chr1:118496688-118496689(+) m6A CDS       24981863 chr1:118501544-118501545(+) m6A CDS       - chr1:118501596-118501597(+) m6A CDS       - chr1:118502071-118502072(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:118502117-118502118(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:118502125-118502126(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:118502263-118502264(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr1:118502485-118502486(+) m6A 3'UTR       24981863 chr1:118502556-118502557(+) m6A 3'UTR       24981863 chr1:118502575-118502576(+) m6A 3'UTR       24981863 chr1:118502588-118502589(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	WDR3	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: WDR3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).