Basic Information:

  VIRBase ID:  

HHID00018037

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          DAZAP2:  NM_014764     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	DAZAP2
miRBase Accession/Entrez ID	MIMAT0026482	9802
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PRTB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DAZAP2	chr12:51635585(+) A-I      intronic chr12:51635472(+) A-I      intronic chr12:51635574(+) A-I      intronic chr12:51635594(+) A-I      intronic chr12:51635609(+) A-I      intronic chr12:51635625(+) A-I      intronic chr12:51638085(+) A-I      intronic chr12:51638161(+) A-I      intronic chr12:51635518(+) A-I      intronic chr12:51635521(+) A-I      intronic chr12:51638006(+) A-I      intronic chr12:51633566(+) A-I      intronic chr12:51638098(+) A-I      intronic chr12:51635519(+) A-I      intronic chr12:51638164(+) A-I      intronic chr12:51638244(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DAZAP2	chr12:51635518(+) A-G intron -    22484847 chr12:51635519(+) A-G intron -    22484847 chr12:51635629(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DAZAP2	chr12:51632599-51632600(+) m6A 5'UTR       24284625//25456834//24981863//26404942//27773535//22608085 chr12:51632628-51632629(+) m6A 5'UTR//exon       24284625//25456834//24981863//26404942//27773535//27371828//22608085 chr12:51632669-51632670(+) m6A 5'UTR//exon       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr12:51632678-51632679(+) m6A 5'UTR//exon       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr12:51632695-51632696(+) m6A CDS//exon       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr12:51632710-51632711(+) m6A exon//intron       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr12:51634188-51634189(+) m6A 5'UTR//CDS//exon//intron       24284625//24209618//24981863 chr12:51634269-51634270(+) m6A exon//intron       24284625//24981863//22575960 chr12:51637021-51637022(+) m6A 3'UTR//exon//intron       26404942 chr12:51637037-51637038(+) m6A 3'UTR//exon//intron       26404942 chr12:51637054-51637055(+) m6A 3'UTR//exon//intron       26404942 chr12:51637066-51637067(+) m6A 3'UTR//exon//intron       26404942 chr12:51639887-51639888(+) m6A CDS//intron       27773535 chr12:51640038-51640039(+) m6A 3'UTR//intron       27773535 chr12:51640110-51640111(+) m6A 3'UTR//intron       24209618 chr12:51640189-51640190(+) m6A 3'UTR//intron       24209618 chr12:51664532-51664533(+) m6A 3'UTR       24209618//25456834//22608085 chr12:51664659-51664660(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr12:51664672-51664673(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr12:51664978-51664979(+) m6A 3'UTR       24981863 chr12:51665083-51665084(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	DAZAP2	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: DAZAP2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).