Detail Information

Basic Information:


  VIRBase ID:  

HHID00017989

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:           SOCS6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-3p SOCS6
miRBase
Accession/Entrez ID		 MIMAT0026482 9306
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CIS-4//CIS4//HSPC060//SOCS-4//SOCS-6//SOCS4//SSI4//STAI4//STATI4

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-3p
rs1367478528 chr15:62824008    C/T
rs146591219 chr15:62824027    C/T
rs1311298147 chr15:62824010    A/G
rs771043955 chr15:62824015    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SOCS6
chr18:67985996(+) A-I      intronic
chr18:67986011(+) A-I      intronic
chr18:67985251(+) A-I      intronic
chr18:67986012(+) A-I      intronic
chr18:67985993(+) A-I      intronic
chr18:67985976(+) A-I      intronic
chr18:67985994(+) A-I      intronic
chr18:67985986(+) A-I      intronic
chr18:67985985(+) A-I      intronic
chr18:67985189(+) A-I      intronic
chr18:67985102(+) A-I      intronic
chr18:67977753(+) A-I      intronic
chr18:67977657(+) A-I      intronic
chr18:67967639(+) A-I      intronic
chr18:67985962(+) A-I      intronic
chr18:67977644(+) A-I      intronic
chr18:67972280(+) A-I      intronic
chr18:67972245(+) A-I      intronic
chr18:67967579(+) A-I      intronic
chr18:67967565(+) A-I      intronic
chr18:67967512(+) A-I      intronic
chr18:67967508(+) A-I      intronic
chr18:67967504(+) A-I      intronic
chr18:67967437(+) A-I      intronic
chr18:67959670(+) A-I      intronic
chr18:67988770(+) A-I      intronic
chr18:67988767(+) A-I      intronic
chr18:67988750(+) A-I      intronic
chr18:67988660(+) A-I      intronic
chr18:67988656(+) A-I      intronic
chr18:67986092(+) A-I      intronic
chr18:67986052(+) A-I      intronic
chr18:67986049(+) A-I      intronic
chr18:67986029(+) A-I      intronic
chr18:67986182(+) A-I      intronic
chr18:67967407(+) A-I      intronic
chr18:67972187(+) A-I      intronic
chr18:67970956(+) A-I      intronic
chr18:67974400(+) A-I      intronic
chr18:67975593(+) A-I      intronic
chr18:67988431(+) A-I      intronic
chr18:67988779(+) A-I      intronic
chr18:67988387(+) A-I      intronic
chr18:67988435(+) A-I      intronic
chr18:67967617(+) A-I      intronic
chr18:67973345(+) A-I      intronic
chr18:67985154(+) A-I      intronic
chr18:67974419(+) A-I      intronic
chr18:67985232(+) A-I      intronic
chr18:67988840(+) A-I      intronic
chr18:67988331(+) A-I      intronic
chr18:67986078(+) A-I      intronic
chr18:67986025(+) A-I      intronic
chr18:67985957(+) A-I      intronic
chr18:67967480(+) A-I      intronic
chr18:67988360(+) A-I      intronic
chr18:67986161(+) A-I      intronic
chr18:67981412(+) A-I      intronic
chr18:67988389(+) A-I      intronic
chr18:67988275(+) A-I      intronic
chr18:67985190(+) A-I      intronic
chr18:67988241(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SOCS6
chr18:67991925-67991926(+) m6A CDS       24284625//24981863//22608085
chr18:67991967-67991968(+) m6A CDS       24284625//24981863//22608085
chr18:67992100-67992101(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr18:67992155-67992156(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr18:67992208-67992209(+) m6A CDS       24284625//25456834//24981863//22608085
chr18:67992331-67992332(+) m6A CDS       24284625
chr18:67992342-67992343(+) m6A CDS       24284625
chr18:67992447-67992448(+) m6A CDS       24284625//24981863//22575960//22608085
chr18:67992502-67992503(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr18:67992524-67992525(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr18:67992545-67992546(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr18:67992559-67992560(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr18:67992631-67992632(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr18:67992712-67992713(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr18:67992718-67992719(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr18:67992877-67992878(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr18:67992887-67992888(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr18:67992949-67992950(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr18:67993037-67993038(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr18:67993064-67993065(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr18:67993132-67993133(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr18:67993185-67993186(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr18:67993235-67993236(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr18:67993253-67993254(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr18:67993294-67993295(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr18:67993361-67993362(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr18:67993447-67993448(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr18:67993460-67993461(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr18:67993474-67993475(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr18:67993522-67993523(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr18:67993551-67993552(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr18:67993577-67993578(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr18:67994450-67994451(+) m6A 3'UTR       24981863
chr18:67994480-67994481(+) m6A 3'UTR       24981863
chr18:67995631-67995632(+) m6A 3'UTR       22575960
chr18:67995641-67995642(+) m6A 3'UTR       22575960
chr18:67995656-67995657(+) m6A 3'UTR       22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-3p
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
SOCS6
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-3p
Interactor2: SOCS6

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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