Basic Information:

  VIRBase ID:  

HHID00017967

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          CACNA1I:  NM_021096     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	CACNA1I
miRBase Accession/Entrez ID	MIMAT0026482	8911
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ca(v)3.3//Cav3.3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CACNA1I	chr22:39984652(+) A-I      intronic chr22:40048275(+) A-I      intronic chr22:40002780(+) A-I      intronic chr22:40048655(+) A-I      intronic chr22:40003978(+) A-I      intronic chr22:39984651(+) A-I      intronic chr22:39982118(+) A-I      intronic chr22:39981931(+) A-I      intronic chr22:40048806(+) A-I      intronic chr22:40048119(+) A-I      intronic chr22:40048763(+) A-I      intronic chr22:39998958(+) A-I      intronic chr22:39991037(+) A-I      intronic chr22:40003736(+) A-I      intronic chr22:39998961(+) A-I      intronic chr22:40004567(+) A-I      intronic chr22:39999109(+) A-I      intronic chr22:39981129(+) A-I      intronic chr22:39981204(+) A-I      intronic chr22:40048803(+) A-I      intronic chr22:40048835(+) A-I      intronic chr22:39999086(+) A-I      intronic chr22:40048831(+) A-I      intronic chr22:40048768(+) A-I      intronic chr22:40048728(+) A-I      intronic chr22:40004637(+) A-I      intronic chr22:40048132(+) A-I      intronic chr22:39991039(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CACNA1I	chr22:40045749-40045750(+) m6A CDS       25456834 chr22:40045850-40045851(+) m6A CDS       25456834 chr22:40082297-40082298(+) m6A CDS       25456834 chr22:40084046-40084047(+) m6A 3'UTR       25456834 chr22:40084145-40084146(+) m6A 3'UTR       25456834 chr22:40084491-40084492(+) m6A 3'UTR       25456834 chr22:40084531-40084532(+) m6A 3'UTR       25456834 chr22:40084988-40084989(+) m6A 3'UTR       25456834 chr22:40085017-40085018(+) m6A 3'UTR       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	CACNA1I	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: CACNA1I

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).