Basic Information:

  VIRBase ID:  

HHID00017914

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          NCOA4:  NM_001145260     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	NCOA4
miRBase Accession/Entrez ID	MIMAT0026482	8031
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARA70//ELE1//PTC3//RFG

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NCOA4	chr10:51589442(+) A-I      3'UTR chr10:51589488(+) A-I      3'UTR chr10:51590444(+) A-I      3'UTR chr10:51589457(+) A-I      3'UTR chr10:51590430(+) A-I      3'UTR chr10:51590420(+) A-I      3'UTR chr10:51573950(+) A-I      intronic chr10:51589438(+) A-I      3'UTR chr10:51578285(+) A-I      intronic chr10:51589252(+) A-I      3'UTR chr10:51589489(+) A-I      3'UTR chr10:51589475(+) A-I      3'UTR chr10:51589470(+) A-I      3'UTR chr10:51589465(+) A-I      3'UTR chr10:51573256(+) A-I      intronic chr10:51573945(+) A-I      intronic chr10:51590431(+) A-I      3'UTR chr10:51573946(+) A-I      intronic chr10:51590493(+) A-I      3'UTR chr10:51590455(+) A-I      3'UTR chr10:51573152(+) A-I      intronic chr10:51574045(+) A-I      intronic chr10:51573987(+) A-I      intronic chr10:51573939(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NCOA4	chr10:51565155-51565156(+) m6A 5'UTR       24981863 chr10:51565207-51565208(+) m6A 5'UTR       24981863 chr10:51565291-51565292(+) m6A 5'UTR       24981863 chr10:51568303-51568304(+) m6A 5'UTR//intron       24981863 chr10:51568333-51568334(+) m6A 5'UTR//intron       24981863 chr10:51572414-51572415(+) m6A 5'UTR//intron       24981863 chr10:51573328-51573329(+) m6A intron       24981863 chr10:51573341-51573342(+) m6A intron       24981863 chr10:51573352-51573353(+) m6A intron       24981863 chr10:51573359-51573360(+) m6A intron       24981863 chr10:51579157-51579158(+) m6A CDS//intron       24981863 chr10:51580652-51580653(+) Y CDS//exon//intron       25219674 chr10:51584658-51584659(+) m6A CDS       24284625 chr10:51584676-51584677(+) m6A CDS       24284625//22608085 chr10:51584799-51584800(+) m6A CDS       24284625//24981863//27773535//22608085 chr10:51584870-51584871(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr10:51584930-51584931(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr10:51584958-51584959(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr10:51584985-51584986(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr10:51585031-51585032(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr10:51585078-51585079(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr10:51585087-51585088(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr10:51585235-51585236(+) m6A CDS       24284625//24981863//27773535//22608085 chr10:51585241-51585242(+) m6A CDS       24284625//24981863//27773535//22608085 chr10:51585307-51585308(+) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr10:51585372-51585373(+) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr10:51585447-51585448(+) m6A CDS       24284625//24981863//27773535//22608085 chr10:51585460-51585461(+) m6A CDS       24284625//24981863//27773535//22608085 chr10:51586302-51586303(+) m6A CDS       27773535 chr10:51586319-51586320(+) m6A CDS       27773535 chr10:51589361-51589362(+) m6A 3'UTR       27773535 chr10:51589910-51589911(+) m6A 3'UTR       27773535 chr10:51589928-51589929(+) m6A 3'UTR       27773535 chr10:51589970-51589971(+) m6A 3'UTR       27773535 chr10:51589989-51589990(+) m6A 3'UTR       27773535 chr10:51590021-51590022(+) m6A 3'UTR       27773535 chr10:51590051-51590052(+) m6A 3'UTR       27773535 chr10:51590193-51590194(+) m6A 3'UTR       27773535 chr10:51590246-51590247(+) m6A 3'UTR       27773535 chr10:51590359-51590360(+) m6A 3'UTR       27773535 chr10:51590367-51590368(+) m6A 3'UTR       27773535 chr10:51590414-51590415(+) m6A 3'UTR       27773535 chr10:51590466-51590467(+) m6A 3'UTR       27773535 chr10:51590552-51590553(+) m6A 3'UTR       27773535 chr10:51590612-51590613(+) m6A 3'UTR       27773535 chr10:51590676-51590677(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	NCOA4	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: NCOA4

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).