Detail Information

Basic Information:


  VIRBase ID:  

HHID00017770

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:           PTGER3:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-3p PTGER3
miRBase
Accession/Entrez ID		 MIMAT0026482 5733
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EP3//EP3-I//EP3-II//EP3-III//EP3-IV//EP3-VI//EP3e//lnc003875//PGE2-R

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-3p
rs1367478528 chr15:62824008    C/T
rs146591219 chr15:62824027    C/T
rs1311298147 chr15:62824010    A/G
rs771043955 chr15:62824015    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PTGER3
chr1:71345038(-) A-I      intronic
chr1:71345033(-) A-I      intronic
chr1:71447274(-) A-I      intronic
chr1:71447291(-) A-I      intronic
chr1:71447300(-) A-I      intronic
chr1:71447312(-) A-I      intronic
chr1:71345013(-) A-I      intronic
chr1:71345027(-) A-I      intronic
chr1:71345050(-) A-I      intronic
chr1:71345118(-) A-I      intronic
chr1:71345124(-) A-I      intronic
chr1:71345067(-) A-I      intronic
chr1:71345126(-) A-I      intronic
chr1:71345133(-) A-I      intronic
chr1:71345729(-) A-I      intronic
chr1:71376194(-) A-I      intronic
chr1:71447180(-) A-I      intronic
chr1:71447271(-) A-I      intronic
chr1:71447364(-) A-I      intronic
chr1:71345203(-) A-I      intronic
chr1:71447305(-) A-I      intronic
chr1:71345728(-) A-I      intronic
chr1:71345718(-) A-I      intronic
chr1:71462698(-) A-I      intronic
chr1:71345045(-) A-I      intronic
chr1:71345692(-) A-I      intronic
chr1:71345190(-) A-I      intronic
chr1:71447139(-) A-I      intronic
chr1:71425037(-) A-I      intronic
chr1:71345763(-) A-I      intronic
chr1:71456032(-) A-I      intronic
chr1:71345206(-) A-I      intronic
chr1:71345519(-) A-I      intronic
chr1:71502384(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PTGER3
chr1:71512605-71512606(-) m6A CDS       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-3p
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
PTGER3
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-3p
Interactor2: PTGER3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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