Basic Information:

  VIRBase ID:  

HHID00017485

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          ATP6V1C1:  NM_001695     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	ATP6V1C1
miRBase Accession/Entrez ID	MIMAT0026482	528
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ATP6C//ATP6D//VATC//Vma5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ATP6V1C1	chr8:104044941(+) A-I      intronic chr8:104044945(+) A-I      intronic chr8:104056196(+) A-I      intronic chr8:104056364(+) A-I      intronic chr8:104056395(+) A-I      intronic chr8:104057992(+) A-I      intronic chr8:104058009(+) A-I      intronic chr8:104058490(+) A-I      intronic chr8:104079450(+) A-I      intronic chr8:104079507(+) A-I      intronic chr8:104080010(+) A-I      intronic chr8:104080060(+) A-I      intronic chr8:104080325(+) A-I      intronic chr8:104083949(+) A-I      3'UTR chr8:104083864(+) A-I      3'UTR chr8:104083879(+) A-I      3'UTR chr8:104083901(+) A-I      3'UTR chr8:104035022(+) A-I      intronic chr8:104059606(+) A-I      intronic chr8:104079372(+) A-I      intronic chr8:104062038(+) A-I      intronic chr8:104080403(+) A-I      intronic chr8:104080308(+) A-I      intronic chr8:104079465(+) A-I      intronic chr8:104054007(+) A-I      intronic chr8:104035019(+) A-I      intronic chr8:104079462(+) A-I      intronic chr8:104058048(+) A-I      intronic chr8:104079516(+) A-I      intronic chr8:104059569(+) A-I      intronic chr8:104079928(+) A-I      intronic chr8:104079946(+) A-I      intronic chr8:104058568(+) A-I      intronic chr8:104058483(+) A-I      intronic chr8:104058703(+) A-I      intronic chr8:104080087(+) A-I      intronic chr8:104079125(+) A-I      intronic chr8:104044743(+) A-I      intronic chr8:104059537(+) A-I      intronic chr8:104058640(+) A-I      intronic chr8:104079205(+) A-I      intronic chr8:104079467(+) A-I      intronic chr8:104084080(+) A-I      3'UTR chr8:104083958(+) A-I      3'UTR chr8:104059542(+) A-I      intronic chr8:104079188(+) A-I      intronic chr8:104080333(+) A-I      intronic chr8:104080081(+) A-I      intronic chr8:104058460(+) A-I      intronic chr8:104077651(+) A-I      intronic chr8:104079533(+) A-I      intronic chr8:104079420(+) A-I      intronic chr8:104079978(+) A-I      intronic chr8:104053844(+) A-I      intronic chr8:104079363(+) A-I      intronic chr8:104078270(+) A-I      intronic chr8:104044809(+) A-I      intronic chr8:104079996(+) A-I      intronic chr8:104079371(+) A-I      intronic chr8:104079903(+) A-I      intronic chr8:104079848(+) A-I      intronic chr8:104056218(+) A-I      intronic chr8:104079480(+) A-I      intronic chr8:104079121(+) A-I      intronic chr8:104056246(+) A-I      intronic chr8:104059570(+) A-I      intronic chr8:104057915(+) A-I      intronic chr8:104058547(+) A-I      intronic chr8:104080047(+) A-I      intronic chr8:104058075(+) A-I      intronic chr8:104079932(+) A-I      intronic chr8:104079575(+) A-I      intronic chr8:104058702(+) A-I      intronic chr8:104079111(+) A-I      intronic chr8:104059529(+) A-I      intronic chr8:104080082(+) A-I      intronic chr8:104078016(+) A-I      intronic chr8:104058552(+) A-I      intronic chr8:104079412(+) A-I      intronic chr8:104079570(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ATP6V1C1	chr8:104056218(+) A-G intron -    22484847 chr8:104056317(+) A-G intron -    22484847 chr8:104058483(+) A-G intron -    22484847 chr8:104058534(+) A-G intron -    22484847 chr8:104058547(+) A-G intron -    22484847 chr8:104058552(+) A-G intron -    22484847 chr8:104058564(+) A-G intron -    22484847 chr8:104058568(+) A-G intron -    22484847 chr8:104077716(+) G-A intron -    22484847 chr8:104079932(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ATP6V1C1	chr8:104081334-104081335(+) m6A 3'UTR       27773535 chr8:104081368-104081369(+) m6A 3'UTR       27773535 chr8:104082203-104082204(+) Y 3'UTR       26075521 chr8:104084924-104084925(+) m6A 3'UTR       25456834//24981863//27773535//22575960//22608085 chr8:104085000-104085001(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:104085026-104085027(+) m6A 3'UTR       24209618//25456834//24981863//27773535//22575960//22608085 chr8:104085036-104085037(+) m6A 3'UTR       24209618//25456834//24981863//27773535//22575960//22608085 chr8:104085076-104085077(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:104085087-104085088(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:104085092-104085093(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:104085149-104085150(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr8:104085172-104085173(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr8:104085184-104085185(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr8:104085211-104085212(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	ATP6V1C1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: ATP6V1C1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).