Detail Information

Basic Information:


  VIRBase ID:  

HHID00017391

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365b-5p:           TMTC3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365b-5p TMTC3
miRBase
Accession/Entrez ID		 MIMAT0022833 160418
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - LIS8//SMILE

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365b-5p
rs367566254 chr17:31575447    T/C
rs374487127 chr17:31575456    G/A
rs752977263 chr17:31575459    G/A
rs752977263 chr17:31575459    G/C
rs755134697 chr17:31575448    C/T
rs767877480 chr17:31575457    CTG/C
rs889256848 chr17:31575450    G/A
rs1245222811 chr17:31575440    G/A
rs1315675828 chr17:31575442    G/A
rs759650574 chr17:31575439    AG/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMTC3
chr12:88557908(+) A-I      intronic
chr12:88557899(+) A-I      intronic
chr12:88556882(+) A-I      intronic
chr12:88556709(+) A-I      intronic
chr12:88556895(+) A-I      intronic
chr12:88557711(+) A-I      intronic
chr12:88556711(+) A-I      intronic
chr12:88557812(+) A-I      intronic
chr12:88557916(+) A-I      intronic
chr12:88556779(+) A-I      intronic
chr12:88556757(+) A-I      intronic
chr12:88556749(+) A-I      intronic
chr12:88557734(+) A-I      intronic
chr12:88585561(+) A-I      intronic
chr12:88557814(+) A-I      intronic
chr12:88552842(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMTC3
chr12:88557814(+) A-G intron -    22484847
chr12:88556749(+) A-G intron -    22484847
chr12:88556757(+) A-G intron -    22484847
chr12:88556779(+) A-G intron -    22484847
chr12:88557734(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMTC3
chr12:88536086-88536087(+) m6A 5'UTR       25456834//24981863
chr12:88536116-88536117(+) m6A 5'UTR       25456834//24981863
chr12:88536155-88536156(+) m6A 5'UTR       25456834//24981863
chr12:88536177-88536178(+) m6A 5'UTR//intron       25456834//24981863
chr12:88586407-88586408(+) m6A CDS       24981863//26404942
chr12:88586451-88586452(+) m6A CDS       24284625//24981863//26404942//22608085
chr12:88586500-88586501(+) m6A CDS       24284625//24981863//26404942//22608085
chr12:88586509-88586510(+) m6A CDS       24284625//24981863//26404942//22608085
chr12:88586529-88586530(+) m6A CDS       24284625//24981863//26404942//22608085
chr12:88586548-88586549(+) m6A CDS       24284625//24981863//26404942//22608085
chr12:88586566-88586567(+) m6A CDS       24284625//24981863//26404942//22608085
chr12:88588624-88588625(+) m6A CDS       24284625//24981863//26404942//22608085
chr12:88588630-88588631(+) m6A CDS       24284625//24981863//26404942//22608085
chr12:88588731-88588732(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr12:88588823-88588824(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr12:88588911-88588912(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr12:88589002-88589003(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr12:88589037-88589038(+) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr12:88589069-88589070(+) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr12:88589242-88589243(+) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr12:88589261-88589262(+) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr12:88589296-88589297(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr12:88589324-88589325(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr12:88589336-88589337(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr12:88589346-88589347(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr12:88589389-88589390(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr12:88589459-88589460(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr12:88589577-88589578(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085
chr12:88589765-88589766(+) m6A 3'UTR       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365b-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle cells     27563705
TMTC3
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365b-5p
Interactor2: TMTC3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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