Basic Information:

  VIRBase ID:  

HHID00017367

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365b-5p:  MIMAT0022833          RAB39B:  NM_171998     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365b-5p	RAB39B
miRBase Accession/Entrez ID	MIMAT0022833	116442
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BGMR//MRX72//WSMN//WSN

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365b-5p	rs367566254 chr17:31575447    T/C rs374487127 chr17:31575456    G/A rs752977263 chr17:31575459    G/A rs752977263 chr17:31575459    G/C rs755134697 chr17:31575448    C/T rs767877480 chr17:31575457    CTG/C rs889256848 chr17:31575450    G/A rs1245222811 chr17:31575440    G/A rs1315675828 chr17:31575442    G/A rs759650574 chr17:31575439    AG/A

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RAB39B	chrX:154488042-154488043(-) Y 3'UTR       26075521 chrX:154489756-154489757(-) m6A 3'UTR       - chrX:154489761-154489762(-) m6A 3'UTR       - chrX:154489773-154489774(-) m6A 3'UTR       25456834 chrX:154489819-154489820(-) m6A 3'UTR       25456834//22608085 chrX:154489900-154489901(-) m6A 3'UTR       25456834//24981863//27773535//27371828//22608085 chrX:154489946-154489947(-) m6A 3'UTR       25456834//24981863//27773535//27371828//22608085 chrX:154489956-154489957(-) m6A 3'UTR       25456834//24981863//27773535//27371828//22608085 chrX:154490001-154490002(-) m6A 3'UTR       25456834//24981863//27773535//27371828//22608085 chrX:154490048-154490049(-) m6A 3'UTR       25456834//27773535//22608085 chrX:154490066-154490067(-) m6A 3'UTR       25456834//27773535//22608085 chrX:154490220-154490221(-) m6A CDS       24981863//27773535//22608085 chrX:154490232-154490233(-) m6A CDS       24981863//27773535//22608085 chrX:154490309-154490310(-) m6A CDS       24981863//27773535//22608085 chrX:154490410-154490411(-) m6A CDS       24981863//27773535//22608085 chrX:154490487-154490488(-) m6A CDS       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365b-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle cells     27563705
	RAB39B	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365b-5p
Interactor2: RAB39B

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).