Basic Information:

  VIRBase ID:  

HHID00017361

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365b-5p:  MIMAT0022833          TMEM106A:  NM_001291587     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365b-5p	TMEM106A
miRBase Accession/Entrez ID	MIMAT0022833	113277
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365b-5p	rs367566254 chr17:31575447    T/C rs374487127 chr17:31575456    G/A rs752977263 chr17:31575459    G/A rs752977263 chr17:31575459    G/C rs755134697 chr17:31575448    C/T rs767877480 chr17:31575457    CTG/C rs889256848 chr17:31575450    G/A rs1245222811 chr17:31575440    G/A rs1315675828 chr17:31575442    G/A rs759650574 chr17:31575439    AG/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMEM106A	chr17:41370650(+) A-I      3'UTR chr17:41370496(+) A-I      3'UTR chr17:41370502(+) A-I      3'UTR chr17:41370515(+) A-I      3'UTR chr17:41370520(+) A-I      3'UTR chr17:41370521(+) A-I      3'UTR chr17:41370441(+) A-I      3'UTR chr17:41370137(+) A-I      3'UTR chr17:41371551(+) A-I      3'UTR chr17:41370549(+) A-I      3'UTR chr17:41370168(+) A-I      3'UTR chr17:41370470(+) A-I      3'UTR chr17:41370484(+) A-I      3'UTR chr17:41370124(+) A-I      3'UTR chr17:41370625(+) A-I      3'UTR chr17:41370629(+) A-I      3'UTR chr17:41370163(+) A-I      3'UTR chr17:41367100(+) A-I      intronic chr17:41370112(+) A-I      3'UTR chr17:41366817(+) A-I      intronic chr17:41370465(+) A-I      3'UTR chr17:41370460(+) A-I      3'UTR chr17:41370433(+) A-I      3'UTR chr17:41370504(+) A-I      3'UTR chr17:41371487(+) A-I      3'UTR chr17:41370416(+) A-I      3'UTR chr17:41370424(+) A-I      3'UTR chr17:41371515(+) A-I      3'UTR chr17:41370179(+) A-I      3'UTR chr17:41370518(+) A-I      3'UTR chr17:41370582(+) A-I      3'UTR chr17:41370448(+) A-I      3'UTR chr17:41370565(+) A-I      3'UTR chr17:41370533(+) A-I      3'UTR chr17:41370165(+) A-I      3'UTR chr17:41370601(+) A-I      3'UTR chr17:41371511(+) A-I      3'UTR chr17:41370519(+) A-I      3'UTR chr17:41370138(+) A-I      3'UTR chr17:41370592(+) A-I      3'UTR chr17:41370503(+) A-I      3'UTR chr17:41370667(+) A-I      3'UTR chr17:41370418(+) A-I      3'UTR chr17:41370608(+) A-I      3'UTR chr17:41370164(+) A-I      3'UTR chr17:41370177(+) A-I      3'UTR chr17:41370595(+) A-I      3'UTR chr17:41371491(+) A-I      3'UTR chr17:41370494(+) A-I      3'UTR chr17:41370089(+) A-I      3'UTR chr17:41370125(+) A-I      3'UTR chr17:41370087(+) A-I      3'UTR chr17:41367269(+) A-I      intronic chr17:41371497(+) A-I      3'UTR chr17:41370586(+) A-I      3'UTR chr17:41366171(+) A-I      intronic chr17:41366859(+) A-I      intronic chr17:41370662(+) A-I      3'UTR chr17:41371525(+) A-I      3'UTR chr17:41371489(+) A-I      3'UTR chr17:41370101(+) A-I      3'UTR chr17:41370569(+) A-I      3'UTR chr17:41370612(+) A-I      3'UTR chr17:41370524(+) A-I      3'UTR chr17:41370640(+) A-I      3'UTR chr17:41370425(+) A-I      3'UTR chr17:41371454(+) A-I      3'UTR chr17:41370630(+) A-I      3'UTR chr17:41370473(+) A-I      3'UTR chr17:41371481(+) A-I      3'UTR chr17:41370093(+) A-I      3'UTR chr17:41370559(+) A-I      3'UTR chr17:41370529(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMEM106A	chr17:41367270(+) G-A intron -    22484847 chr17:41370087(+) A-G intron -    22484847 chr17:41370164(+) A-G intron -    22484847 chr17:41370179(+) A-G intron -    22484847 chr17:41370416(+) A-G intron -    22484847 chr17:41370418(+) A-G intron -    22484847 chr17:41370424(+) A-G intron -    22484847 chr17:41370433(+) A-G intron -    22484847 chr17:41370460(+) A-G intron -    22484847 chr17:41370465(+) A-G intron -    22484847 chr17:41370504(+) A-G intron -    22484847 chr17:41370518(+) A-G intron -    22484847 chr17:41370524(+) A-G intron -    22484847 chr17:41370529(+) A-G intron -    22484847 chr17:41370533(+) A-G intron -    22484847 chr17:41370565(+) A-G intron -    22484847 chr17:41370569(+) A-G intron -    22484847 chr17:41370592(+) A-G intron -    22484847 chr17:41370601(+) A-G intron -    22484847 chr17:41370608(+) A-G intron -    22484847 chr17:41370630(+) A-G intron -    22484847 chr17:41370667(+) A-G intron -    22484847 chr17:41371491(+) A-G intron -    22484847 chr17:41371497(+) A-G intron -    22484847 chr17:41371515(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMEM106A	chr17:41364246-41364247(+) m6A 5'UTR//exon//intron       - chr17:41364402-41364403(+) m6A 5'UTR//exon//intron       - chr17:41364408-41364409(+) m6A 5'UTR//exon//intron       - chr17:41365043-41365044(+) m6A 5'UTR//exon//intron       - chr17:41369767-41369768(+) m6A CDS       - chr17:41369898-41369899(+) m6A 3'UTR       - chr17:41370601-41370602(+) m6A 3'UTR       - chr17:41370669-41370670(+) m6A 3'UTR       - chr17:41370687-41370688(+) m6A 3'UTR       - chr17:41371580-41371581(+) m6A 3'UTR       - chr17:41371795-41371796(+) m6A 3'UTR       24284625 chr17:41371807-41371808(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365b-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle cells     27563705
	TMEM106A	Chromatin K562 cells     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365b-5p
Interactor2: TMEM106A

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).