Basic Information:

  VIRBase ID:  

HHID00017327

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365b-5p:  MIMAT0022833          APOL4:  NM_145660     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365b-5p	APOL4
miRBase Accession/Entrez ID	MIMAT0022833	80832
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	APOL-IV//APOLIV

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365b-5p	rs367566254 chr17:31575447    T/C rs374487127 chr17:31575456    G/A rs752977263 chr17:31575459    G/A rs752977263 chr17:31575459    G/C rs755134697 chr17:31575448    C/T rs767877480 chr17:31575457    CTG/C rs889256848 chr17:31575450    G/A rs1245222811 chr17:31575440    G/A rs1315675828 chr17:31575442    G/A rs759650574 chr17:31575439    AG/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	APOL4	chr22:36598304(-) A-I      intronic chr22:36598291(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	APOL4	chr22:36585623-36585624(-) m6A 3'UTR//exon       24981863 chr22:36585641-36585642(-) m6A 3'UTR//exon       24981863 chr22:36585663-36585664(-) m6A 3'UTR//exon       24981863 chr22:36585707-36585708(-) m6A 3'UTR//exon       24981863 chr22:36585722-36585723(-) m6A 3'UTR//exon       24981863 chr22:36585766-36585767(-) m6A 3'UTR//exon       24981863 chr22:36585807-36585808(-) m6A 3'UTR//exon       24981863 chr22:36586840-36586841(-) m6A 3'UTR//exon       24981863 chr22:36586942-36586943(-) m6A 3'UTR//exon       24981863 chr22:36586966-36586967(-) m6A 3'UTR//exon       24981863 chr22:36587033-36587034(-) m6A 3'UTR//exon       24981863 chr22:36587081-36587082(-) m6A 3'UTR//exon       24981863 chr22:36587096-36587097(-) m6A 3'UTR//exon       24981863 chr22:36587237-36587238(-) m6A CDS//exon       24981863 chr22:36587246-36587247(-) m6A CDS//exon       24981863 chr22:36587306-36587307(-) m6A CDS//exon       24981863 chr22:36587349-36587350(-) m6A CDS//exon       24981863 chr22:36587358-36587359(-) m6A CDS//exon       24981863 chr22:36587519-36587520(-) m6A CDS//exon       24981863//22575960 chr22:36587575-36587576(-) m6A CDS//exon       24981863//22575960 chr22:36587597-36587598(-) m6A CDS//exon       24981863 chr22:36587873-36587874(-) m6A CDS//exon       24981863 chr22:36587889-36587890(-) m6A CDS//exon       24981863 chr22:36587895-36587896(-) m6A CDS//exon       24981863 chr22:36597896-36597897(-) m6A 5'UTR//exon//intron       24981863 chr22:36597931-36597932(-) m6A 5'UTR//exon//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365b-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle cells     27563705
	APOL4	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365b-5p
Interactor2: APOL4

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).