Detail Information

Basic Information:


  VIRBase ID:  

HHID00017311

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365b-5p:           CENPM:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365b-5p CENPM
miRBase
Accession/Entrez ID		 MIMAT0022833 79019
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C22orf18//CENP-M//PANE1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365b-5p
rs367566254 chr17:31575447    T/C
rs374487127 chr17:31575456    G/A
rs752977263 chr17:31575459    G/A
rs752977263 chr17:31575459    G/C
rs755134697 chr17:31575448    C/T
rs767877480 chr17:31575457    CTG/C
rs889256848 chr17:31575450    G/A
rs1245222811 chr17:31575440    G/A
rs1315675828 chr17:31575442    G/A
rs759650574 chr17:31575439    AG/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CENPM
chr22:42336486(-) A-I      intronic
chr22:42336528(-) A-I      intronic
chr22:42336583(-) A-I      intronic
chr22:42336594(-) A-I      intronic
chr22:42336622(-) A-I      intronic
chr22:42336563(-) A-I      intronic
chr22:42338565(-) A-I      intronic
chr22:42338511(-) A-I      intronic
chr22:42338510(-) A-I      intronic
chr22:42338393(-) A-I      intronic
chr22:42338358(-) A-I      intronic
chr22:42336640(-) A-I      intronic
chr22:42338721(-) A-I      intronic
chr22:42336498(-) A-I      intronic
chr22:42338937(-) A-I      intronic
chr22:42336495(-) A-I      intronic
chr22:42338611(-) A-I      intronic
chr22:42338826(-) A-I      intronic
chr22:42338708(-) A-I      intronic
chr22:42338587(-) A-I      intronic
chr22:42338698(-) A-I      intronic
chr22:42338643(-) A-I      intronic
chr22:42336617(-) A-I      intronic
chr22:42338814(-) A-I      intronic
chr22:42336458(-) A-I      intronic
chr22:42336457(-) A-I      intronic
chr22:42336674(-) A-I      intronic
chr22:42336568(-) A-I      intronic
chr22:42336425(-) A-I      intronic
chr22:42336569(-) A-I      intronic
chr22:42336514(-) A-I      intronic
chr22:42336565(-) A-I      intronic
chr22:42336627(-) A-I      intronic
chr22:42336608(-) A-I      intronic
chr22:42338932(-) A-I      intronic
chr22:42336527(-) A-I      intronic
chr22:42338882(-) A-I      intronic
chr22:42338633(-) A-I      intronic
chr22:42336567(-) A-I      intronic
chr22:42336487(-) A-I      intronic
chr22:42336572(-) A-I      intronic
chr22:42338397(-) A-I      intronic
chr22:42338823(-) A-I      intronic
chr22:42336424(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CENPM
chr22:42337464(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CENPM
chr22:42334775-42334776(-) m6A 3'UTR       24981863//22608085
chr22:42334868-42334869(-) m6A 3'UTR       24284625//24981863//27773535//27371828//22608085
chr22:42335005-42335006(-) m6A 3'UTR       24981863
chr22:42335043-42335044(-) Y 3'UTR       26075521
chr22:42335111-42335112(-) m6A 3'UTR//CDS       27371828
chr22:42336161-42336162(-) m6A CDS//intron       27371828
chr22:42342441-42342442(-) m6A CDS//exon       27773536
chr22:42342459-42342460(-) m6A 5'UTR//CDS//exon       27773536
chr22:42342669-42342670(-) m6A 5'UTR//intron       27773536
chr22:42343039-42343040(-) m6A CDS//exon       24981863//27773536
chr22:42343057-42343058(-) m6A CDS//exon       24981863//27773536
chr22:42343125-42343126(-) Am 5'UTR//exon       -
chr22:42343141-42343142(-) m6A 5'UTR//exon       24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365b-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle cells     27563705
CENPM
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365b-5p
Interactor2: CENPM

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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