Basic Information:

  VIRBase ID:  

HHID00017291

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365b-5p:  MIMAT0022833          RNPEPL1:  NM_018226     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365b-5p	RNPEPL1
miRBase Accession/Entrez ID	MIMAT0022833	57140
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365b-5p	rs367566254 chr17:31575447    T/C rs374487127 chr17:31575456    G/A rs752977263 chr17:31575459    G/A rs752977263 chr17:31575459    G/C rs755134697 chr17:31575448    C/T rs767877480 chr17:31575457    CTG/C rs889256848 chr17:31575450    G/A rs1245222811 chr17:31575440    G/A rs1315675828 chr17:31575442    G/A rs759650574 chr17:31575439    AG/A

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RNPEPL1	chr2:241508421-241508422(+) m6A 5'UTR//exon//intron       24209618 chr2:241517049-241517050(+) m6A CDS//exon       24284625 chr2:241517220-241517221(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr2:241517226-241517227(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr2:241517341-241517342(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr2:241517467-241517468(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr2:241517488-241517489(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr2:241517496-241517497(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr2:241517804-241517805(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr2:241517810-241517811(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr2:241517816-241517817(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr2:241517843-241517844(+) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//22575960//22608085 chr2:241517909-241517910(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960 chr2:241517924-241517925(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960 chr2:241517943-241517944(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960 chr2:241517948-241517949(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960 chr2:241518090-241518091(+) m6A 3'UTR//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365b-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle cells     27563705
	RNPEPL1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365b-5p
Interactor2: RNPEPL1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).