Basic Information:

  VIRBase ID:  

HHID00017258

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365b-5p:  MIMAT0022833          WNT4:  NM_030761     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365b-5p	WNT4
miRBase Accession/Entrez ID	MIMAT0022833	54361
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	SERKAL//WNT-4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365b-5p	rs367566254 chr17:31575447    T/C rs374487127 chr17:31575456    G/A rs752977263 chr17:31575459    G/A rs752977263 chr17:31575459    G/C rs755134697 chr17:31575448    C/T rs767877480 chr17:31575457    CTG/C rs889256848 chr17:31575450    G/A rs1245222811 chr17:31575440    G/A rs1315675828 chr17:31575442    G/A rs759650574 chr17:31575439    AG/A

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WNT4	chr1:22444072-22444073(-) m6A 3'UTR       25456834 chr1:22444087-22444088(-) m6A 3'UTR       25456834 chr1:22444103-22444104(-) m6A 3'UTR       25456834 chr1:22444181-22444182(-) m6A 3'UTR       25456834 chr1:22445184-22445185(-) m6A 3'UTR       25456834 chr1:22445968-22445969(-) m6A 3'UTR       25456834 chr1:22446019-22446020(-) m6A 3'UTR       25456834//24981863 chr1:22446074-22446075(-) m6A 3'UTR       25456834//24981863 chr1:22446105-22446106(-) m6A 3'UTR       25456834//24981863 chr1:22446481-22446482(-) m6A 3'UTR       - chr1:22446750-22446751(-) m6A CDS       25456834//24981863 chr1:22446792-22446793(-) m6A CDS       25456834//24981863 chr1:22453657-22453658(-) m6A 3'UTR//intron       24981863 chr1:22453675-22453676(-) m6A 3'UTR//intron       25456834//24981863 chr1:22453724-22453725(-) m6A 3'UTR//intron       25456834//24981863 chr1:22453765-22453766(-) m6A CDS//intron       25456834//24981863 chr1:22453802-22453803(-) m6A CDS//intron       25456834 chr1:22453838-22453839(-) m6A CDS//intron       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365b-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle cells     27563705
	WNT4	Exosome Blood     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365b-5p
Interactor2: WNT4

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).