Basic Information:

  VIRBase ID:  

HHID00017239

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365b-5p:  MIMAT0022833          PACSIN1:  NM_020804     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365b-5p	PACSIN1
miRBase Accession/Entrez ID	MIMAT0022833	29993
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	SDPI

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365b-5p	rs367566254 chr17:31575447    T/C rs374487127 chr17:31575456    G/A rs752977263 chr17:31575459    G/A rs752977263 chr17:31575459    G/C rs755134697 chr17:31575448    C/T rs767877480 chr17:31575457    CTG/C rs889256848 chr17:31575450    G/A rs1245222811 chr17:31575440    G/A rs1315675828 chr17:31575442    G/A rs759650574 chr17:31575439    AG/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PACSIN1	chr6:34457927(+) A-I      intronic chr6:34447812(+) A-I      intronic chr6:34447777(+) A-I      intronic chr6:34447800(+) A-I      intronic chr6:34465968(+) A-I      intronic chr6:34454840(+) A-I      intronic chr6:34449089(+) A-I      intronic chr6:34466036(+) A-I      intronic chr6:34467494(+) A-I      intronic chr6:34449262(+) A-I      intronic chr6:34457940(+) A-I      intronic chr6:34449109(+) A-I      intronic chr6:34448962(+) A-I      intronic chr6:34466303(+) A-I      intronic chr6:34450077(+) A-I      intronic chr6:34449286(+) A-I      intronic chr6:34439887(+) A-I      intronic chr6:34454689(+) A-I      intronic chr6:34454826(+) A-I      intronic chr6:34445035(+) A-I      intronic chr6:34438779(+) A-I      intronic chr6:34466459(+) A-I      intronic chr6:34445034(+) A-I      intronic chr6:34445012(+) A-I      intronic chr6:34445086(+) A-I      intronic chr6:34466041(+) A-I      intronic chr6:34449101(+) A-I      intronic chr6:34439917(+) A-I      intronic chr6:34467293(+) A-I      intronic chr6:34470987(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PACSIN1	chr6:34497243-34497244(+) m6A CDS//exon       24981863 chr6:34500257-34500258(+) m6A CDS       25456834 chr6:34501538-34501539(+) m6A 3'UTR       25456834 chr6:34501577-34501578(+) m6A 3'UTR       25456834 chr6:34501597-34501598(+) m6A 3'UTR       25456834 chr6:34501703-34501704(+) m6A 3'UTR       25456834 chr6:34501714-34501715(+) m6A 3'UTR       25456834 chr6:34501719-34501720(+) m6A 3'UTR       25456834 chr6:34501760-34501761(+) m6A 3'UTR       25456834 chr6:34501804-34501805(+) m6A 3'UTR       25456834 chr6:34501840-34501841(+) m6A 3'UTR       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365b-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle cells     27563705
	PACSIN1	Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365b-5p
Interactor2: PACSIN1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).