Basic Information:

  VIRBase ID:  

HHID00017166

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365b-5p:  MIMAT0022833          LAT2:  NM_032464     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365b-5p	LAT2
miRBase Accession/Entrez ID	MIMAT0022833	7462
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSPC046//LAB//NTAL//WBSCR15//WBSCR5//WSCR5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365b-5p	rs367566254 chr17:31575447    T/C rs374487127 chr17:31575456    G/A rs752977263 chr17:31575459    G/A rs752977263 chr17:31575459    G/C rs755134697 chr17:31575448    C/T rs767877480 chr17:31575457    CTG/C rs889256848 chr17:31575450    G/A rs1245222811 chr17:31575440    G/A rs1315675828 chr17:31575442    G/A rs759650574 chr17:31575439    AG/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LAT2	chr7:73637742(+) A-I      intronic chr7:73637669(+) A-I      intronic chr7:73637620(+) A-I      intronic chr7:73637606(+) A-I      intronic chr7:73637566(+) A-I      intronic chr7:73637107(+) A-I      intronic chr7:73637038(+) A-I      intronic chr7:73636965(+) A-I      intronic chr7:73633302(+) A-I      intronic chr7:73633289(+) A-I      intronic chr7:73631663(+) A-I      intronic chr7:73631533(+) A-I      intronic chr7:73631529(+) A-I      intronic chr7:73631507(+) A-I      intronic chr7:73631500(+) A-I      intronic chr7:73642251(+) A-I      intronic chr7:73626510(+) A-I      intronic chr7:73626509(+) A-I      intronic chr7:73642277(+) A-I      intronic chr7:73641436(+) A-I      intronic chr7:73640861(+) A-I      intronic chr7:73637779(+) A-I      intronic chr7:73631506(+) A-I      intronic chr7:73631605(+) A-I      intronic chr7:73637179(+) A-I      intronic chr7:73625045(+) A-I      intronic chr7:73625022(+) A-I      intronic chr7:73642092(+) A-I      intronic chr7:73631602(+) A-I      intronic chr7:73631610(+) A-I      intronic chr7:73637673(+) A-I      intronic chr7:73642076(+) A-I      intronic chr7:73642066(+) A-I      intronic chr7:73642060(+) A-I      intronic chr7:73641797(+) A-I      intronic chr7:73641691(+) A-I      intronic chr7:73641529(+) A-I      intronic chr7:73642350(+) A-I      intronic chr7:73626556(+) A-I      intronic chr7:73641501(+) A-I      intronic chr7:73641472(+) A-I      intronic chr7:73642427(+) A-I      intronic chr7:73642386(+) A-I      intronic chr7:73642344(+) A-I      intronic chr7:73629202(+) A-I      5'UTR chr7:73640744(+) A-I      3'UTR chr7:73639603(+) A-I      3'UTR chr7:73640493(+) A-I      3'UTR chr7:73640607(+) A-I      3'UTR chr7:73629201(+) A-I      5'UTR chr7:73633256(+) A-I      intronic chr7:73642359(+) A-I      intronic chr7:73635586(+) A-I      intronic chr7:73631601(+) A-I      intronic chr7:73636944(+) A-I      intronic chr7:73633085(+) A-I      intronic chr7:73642434(+) A-I      intronic chr7:73642421(+) A-I      intronic chr7:73631686(+) A-I      intronic chr7:73637004(+) A-I      intronic chr7:73636496(+) A-I      intronic chr7:73625096(+) A-I      intronic chr7:73642291(+) A-I      intronic chr7:73636924(+) A-I      intronic chr7:73636676(+) A-I      intronic chr7:73642082(+) A-I      intronic chr7:73640877(+) A-I      intronic chr7:73642038(+) A-I      intronic chr7:73639645(+) A-I      3'UTR chr7:73640712(+) A-I      3'UTR chr7:73640722(+) A-I      3'UTR chr7:73640568(+) A-I      3'UTR chr7:73639639(+) A-I      3'UTR chr7:73640679(+) A-I      3'UTR chr7:73640368(+) A-I      3'UTR chr7:73640717(+) A-I      3'UTR chr7:73640507(+) A-I      3'UTR chr7:73639613(+) A-I      3'UTR chr7:73641489(+) A-I      intronic chr7:73641715(+) A-I      intronic chr7:73642998(+) A-I      intronic chr7:73637699(+) A-I      intronic chr7:73641476(+) A-I      intronic chr7:73637167(+) A-I      intronic chr7:73641435(+) A-I      intronic chr7:73631676(+) A-I      intronic chr7:73642104(+) A-I      intronic chr7:73631600(+) A-I      intronic chr7:73640841(+) A-I      intronic chr7:73641802(+) A-I      intronic chr7:73641750(+) A-I      intronic chr7:73637760(+) A-I      intronic chr7:73640927(+) A-I      intronic chr7:73637033(+) A-I      intronic chr7:73637003(+) A-I      intronic chr7:73637713(+) A-I      intronic chr7:73641689(+) A-I      intronic chr7:73636960(+) A-I      intronic chr7:73637043(+) A-I      intronic chr7:73642385(+) A-I      intronic chr7:73637749(+) A-I      intronic chr7:73641824(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	LAT2	chr7:73637760(+) A-I intron -    22327324 chr7:73640717(+) A-I intron -    22327324 chr7:73640722(+) A-I intron -    22327324 chr7:73642038(+) A-I intron -    22327324 chr7:73642082(+) A-I intron -    22327324 chr7:73640568(+) A-G intron -    21725310 chr7:73640717(+) A-G intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LAT2	chr7:73624403-73624404(+) m6A 5'UTR//exon       24209618 chr7:73624410-73624411(+) m6A 5'UTR//exon       24209618 chr7:73638386-73638387(+) m6A 3'UTR//CDS//exon       25456834 chr7:73638412-73638413(+) m6A 3'UTR//CDS//exon       25456834 chr7:73638482-73638483(+) m6A 3'UTR//CDS//exon       25456834 chr7:73639029-73639030(+) m6A 3'UTR//CDS//exon       24209618 chr7:73639077-73639078(+) m6A 3'UTR//exon       24209618 chr7:73640810-73640811(+) m6A 3'UTR//intron       24209618 chr7:73643291-73643292(+) m6A 3'UTR//exon       24209618 chr7:73643307-73643308(+) m6A 3'UTR//exon       24209618 chr7:73643328-73643329(+) m6A 3'UTR//exon       24209618 chr7:73643387-73643388(+) m6A 3'UTR//exon       24209618 chr7:73643403-73643404(+) m6A 3'UTR       24209618 chr7:73643437-73643438(+) m6A 3'UTR       24209618//24981863 chr7:73643589-73643590(+) m6A 3'UTR       - chr7:73643835-73643836(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365b-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle cells     27563705
	LAT2	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365b-5p
Interactor2: LAT2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).