Basic Information:

  VIRBase ID:  

HHID00017098

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365b-5p:  MIMAT0022833          CCND2:  NM_001759     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365b-5p	CCND2
miRBase Accession/Entrez ID	MIMAT0022833	894
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	KIAK0002//MPPH3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365b-5p	rs367566254 chr17:31575447    T/C rs374487127 chr17:31575456    G/A rs752977263 chr17:31575459    G/A rs752977263 chr17:31575459    G/C rs755134697 chr17:31575448    C/T rs767877480 chr17:31575457    CTG/C rs889256848 chr17:31575450    G/A rs1245222811 chr17:31575440    G/A rs1315675828 chr17:31575442    G/A rs759650574 chr17:31575439    AG/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CCND2	chr12:4407683(+) A-I      intronic chr12:4406504(+) A-I      intronic chr12:4408273(+) A-I      intronic chr12:4408319(+) A-I      intronic chr12:4407661(+) A-I      intronic chr12:4408272(+) A-I      intronic chr12:4406535(+) A-I      intronic chr12:4408325(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CCND2	chr12:4406341(+) A-T intron -    22484847 chr12:4406592(+) C-T intron -    22484847 chr12:4406734(+) C-T intron -    22484847 chr12:4406735(+) T-C intron -    22484847 chr12:4406736(+) C-A intron -    22484847 chr12:4407661(+) A-G intron -    22484847 chr12:4404682(+) T-C intron -    22484847 chr12:4408272(+) A-G intron -    22484847 chr12:4408273(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCND2	chr12:4382959-4382960(+) m6A 5'UTR       25456834//24981863 chr12:4382977-4382978(+) m6A 5'UTR       25456834//24981863 chr12:4383080-4383081(+) m6A 5'UTR       25456834//24981863 chr12:4383140-4383141(+) m6A 5'UTR       24981863 chr12:4383146-4383147(+) m6A 5'UTR       - chr12:4383154-4383155(+) m6A 5'UTR       - chr12:4409504-4409505(+) m6A 3'UTR       22608085 chr12:4409518-4409519(+) m6A 3'UTR       24981863//22608085 chr12:4409578-4409579(+) m6A 3'UTR       24209618//24981863//22608085 chr12:4409622-4409623(+) m6A 3'UTR       24209618//24981863//22608085 chr12:4409650-4409651(+) m6A 3'UTR       24209618//24981863//22608085 chr12:4409673-4409674(+) m6A 3'UTR       24209618//24981863//22608085 chr12:4409694-4409695(+) m6A 3'UTR       24209618//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365b-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle cells     27563705
	CCND2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365b-5p
Interactor2: CCND2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).