Detail Information

Basic Information:


  VIRBase ID:  

HHID00017020

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1307-5p:           DICER1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1307-5p DICER1
miRBase
Accession/Entrez ID		 MIMAT0022727 23405
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DCR1//Dicer//Dicer1e//GLOW//HERNA//K12H4.8-LIKE//MNG1//RMSE2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1307-5p
rs1309634229 chr10:103394348    C/CCGGTCGAGATTGGTACA
rs1361155526 chr10:103394342    G/T
rs1368355489 chr10:103394339    CGAGCCGGTCGA/C
rs752308702 chr10:103394349    G/A
rs753442502 chr10:103394342    GCCGGTCGAGGT/GCCGGTCGAGGTCCGGTCGAGGT
rs753442502 chr10:103394342    GCCGGTCGAGGT/G
rs758906629 chr10:103394350    A/AGGTCC
rs762691771 chr10:103394351    G/A
rs766738312 chr10:103394345    G/A
rs766738312 chr10:103394345    G/C
rs909057468 chr10:103394348    C/T
rs1485833698 chr10:103394358    T/C
rs745681690 chr10:103394354    C/T
rs750389441 chr10:103394360    G/A
rs750389441 chr10:103394360    G/C
rs751122680 chr10:103394356    G/A
rs757138030 chr10:103394359    C/G
rs757138030 chr10:103394359    C/T
rs763490878 chr10:103394355    C/G
rs763490878 chr10:103394355    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DICER1
chr14:95617269(-) A-I      intronic
chr14:95617234(-) A-I      intronic
chr14:95617267(-) A-I      intronic
chr14:95617338(-) A-I      intronic
chr14:95617317(-) A-I      intronic
chr14:95608532(-) A-I      intronic
chr14:95614285(-) A-I      intronic
chr14:95617280(-) A-I      intronic
chr14:95597526(-) A-I      intronic
chr14:95616760(-) A-I      intronic
chr14:95616576(-) A-I      intronic
chr14:95616771(-) A-I      intronic
chr14:95617357(-) A-I      intronic
chr14:95617355(-) A-I      intronic
chr14:95615385(-) A-I      intronic
chr14:95616741(-) A-I      intronic
chr14:95617292(-) A-I      intronic
chr14:95613681(-) A-I      intronic
chr14:95597535(-) A-I      intronic
chr14:95617300(-) A-I      intronic
chr14:95617325(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DICER1
chr14:95615385(-) A-G intron -    22484847
chr14:95616576(-) A-G intron -    22484847
chr14:95617280(-) A-G intron -    22484847
chr14:95617300(-) A-G intron -    22484847
chr14:95617325(-) A-G intron -    22484847
chr14:95617355(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DICER1
chr14:95552701-95552702(-) m6A 3'UTR       27773535
chr14:95553018-95553019(-) m6A 3'UTR       27773535
chr14:95553532-95553533(-) m6A 3'UTR       -
chr14:95554128-95554129(-) m6A 3'UTR       24981863
chr14:95555754-95555755(-) m6A 3'UTR//intron       27773535
chr14:95555818-95555819(-) m6A 3'UTR//intron       27773535
chr14:95555825-95555826(-) m6A 3'UTR//intron       27773535
chr14:95556649-95556650(-) m6A 3'UTR//intron       27773535
chr14:95556677-95556678(-) m6A 3'UTR//intron       27773535//22608085
chr14:95556757-95556758(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556800-95556801(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556805-95556806(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556812-95556813(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556832-95556833(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556986-95556987(-) m6A CDS//exon       24981863//27773535
chr14:95560387-95560388(-) m6A CDS       27773535
chr14:95560420-95560421(-) m6A CDS       27773535
chr14:95560450-95560451(-) m6A CDS       27773535
chr14:95561748-95561749(-) m6A 3'UTR//intron       27773535
chr14:95561756-95561757(-) m6A 3'UTR//intron       27773535
chr14:95562141-95562142(-) m6A CDS//intron       22608085
chr14:95562284-95562285(-) m6A CDS       24284625//24981863//27773535//22608085
chr14:95562349-95562350(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:95562409-95562410(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95562467-95562468(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95562574-95562575(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95562655-95562656(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95562912-95562913(-) m6A CDS       24284625//24981863//26404942//27773535//22608085
chr14:95563020-95563021(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr14:95563042-95563043(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr14:95566153-95566154(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr14:95566230-95566231(-) m6A CDS       27773535
chr14:95569847-95569848(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95569867-95569868(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95569935-95569936(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95570052-95570053(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr14:95570148-95570149(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr14:95570277-95570278(-) m6A CDS//exon       24284625//24981863//22608085
chr14:95570314-95570315(-) m6A CDS//exon       24284625//24981863//22608085
chr14:95570448-95570449(-) m6A CDS//exon//intron       24284625//22608085
chr14:95572444-95572445(-) m6A CDS//exon       27773535
chr14:95572465-95572466(-) m6A CDS//exon       27773535
chr14:95574735-95574736(-) Tm CDS       -
chr14:95583004-95583005(-) m6A CDS//intron       24981863//27773535
chr14:95583967-95583968(-) m6A CDS//exon       24981863//27773535
chr14:95583991-95583992(-) m6A CDS//exon       24981863//27773535
chr14:95584024-95584025(-) m6A CDS//exon       24981863//27773535
chr14:95584069-95584070(-) m6A CDS//exon       24981863//27773535//22608085
chr14:95590535-95590536(-) m6A CDS//exon       24981863//27773535//22608085
chr14:95590614-95590615(-) m6A CDS       24284625//24981863//26404942//27773535//22608085
chr14:95590744-95590745(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr14:95590771-95590772(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr14:95590862-95590863(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr14:95590906-95590907(-) m6A CDS       24284625//24981863//22608085
chr14:95590924-95590925(-) m6A CDS       24284625//24981863//22608085
chr14:95590966-95590967(-) m6A CDS       24284625//24981863//22608085
chr14:95590994-95590995(-) m6A CDS       24284625//24981863//22608085
chr14:95592919-95592920(-) m6A CDS       24284625//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1307-5p
Exosome Plasma     23663360
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Blood|B lymphoblastoid cells|Chronic lymphocytic leukemia cells|Endothelial cells|Kidney tissue|Lymphoma tissue     -
Microvesicle Serum     24797360
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
DICER1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1307-5p
Interactor2: DICER1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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