Basic Information:

  VIRBase ID:  

HHID00017012

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1307-5p:  MIMAT0022727          CDC42BPB:  NM_006035     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1307-5p	CDC42BPB
miRBase Accession/Entrez ID	MIMAT0022727	9578
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MRCKB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1307-5p	rs1309634229 chr10:103394348    C/CCGGTCGAGATTGGTACA rs1361155526 chr10:103394342    G/T rs1368355489 chr10:103394339    CGAGCCGGTCGA/C rs752308702 chr10:103394349    G/A rs753442502 chr10:103394342    GCCGGTCGAGGT/GCCGGTCGAGGTCCGGTCGAGGT rs753442502 chr10:103394342    GCCGGTCGAGGT/G rs758906629 chr10:103394350    A/AGGTCC rs762691771 chr10:103394351    G/A rs766738312 chr10:103394345    G/A rs766738312 chr10:103394345    G/C rs909057468 chr10:103394348    C/T rs1485833698 chr10:103394358    T/C rs745681690 chr10:103394354    C/T rs750389441 chr10:103394360    G/A rs750389441 chr10:103394360    G/C rs751122680 chr10:103394356    G/A rs757138030 chr10:103394359    C/G rs757138030 chr10:103394359    C/T rs763490878 chr10:103394355    C/G rs763490878 chr10:103394355    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDC42BPB	chr14:103427404(-) A-I      intronic chr14:103427409(-) A-I      intronic chr14:103446664(-) A-I      intronic chr14:103448167(-) A-I      intronic chr14:103427454(-) A-I      intronic chr14:103427436(-) A-I      intronic chr14:103405090(-) A-I      intronic chr14:103513482(-) A-I      intronic chr14:103513472(-) A-I      intronic chr14:103405051(-) A-I      intronic chr14:103463005(-) A-I      intronic chr14:103482142(-) A-I      intronic chr14:103403085(-) A-I      intronic chr14:103513173(-) A-I      intronic chr14:103482143(-) A-I      intronic chr14:103513170(-) A-I      intronic chr14:103482160(-) A-I      intronic chr14:103425277(-) A-I      intronic chr14:103487681(-) A-I      intronic chr14:103463004(-) A-I      intronic chr14:103487727(-) A-I      intronic chr14:103445181(-) A-I      intronic chr14:103513441(-) A-I      intronic chr14:103487740(-) A-I      intronic chr14:103513158(-) A-I      intronic chr14:103513139(-) A-I      intronic chr14:103432050(-) A-I      intronic chr14:103487751(-) A-I      intronic chr14:103508876(-) A-I      intronic chr14:103488788(-) A-I      intronic chr14:103427246(-) A-I      intronic chr14:103504309(-) A-I      intronic chr14:103504282(-) A-I      intronic chr14:103489552(-) A-I      intronic chr14:103462948(-) A-I      intronic chr14:103427460(-) A-I      intronic chr14:103425253(-) A-I      intronic chr14:103489557(-) A-I      intronic chr14:103462933(-) A-I      intronic chr14:103502767(-) A-I      intronic chr14:103462920(-) A-I      intronic chr14:103489581(-) A-I      intronic chr14:103502764(-) A-I      intronic chr14:103462906(-) A-I      intronic chr14:103502095(-) A-I      intronic chr14:103501948(-) A-I      intronic chr14:103501640(-) A-I      intronic chr14:103501621(-) A-I      intronic chr14:103501073(-) A-I      intronic chr14:103462905(-) A-I      intronic chr14:103501055(-) A-I      intronic chr14:103427380(-) A-I      intronic chr14:103501007(-) A-I      intronic chr14:103426299(-) A-I      intronic chr14:103489642(-) A-I      intronic chr14:103462509(-) A-I      intronic chr14:103462495(-) A-I      intronic chr14:103500993(-) A-I      intronic chr14:103425299(-) A-I      intronic chr14:103500592(-) A-I      intronic chr14:103499227(-) A-I      intronic chr14:103499148(-) A-I      intronic chr14:103462487(-) A-I      intronic chr14:103446686(-) A-I      intronic chr14:103446682(-) A-I      intronic chr14:103446633(-) A-I      intronic chr14:103445834(-) A-I      intronic chr14:103445781(-) A-I      intronic chr14:103445757(-) A-I      intronic chr14:103445728(-) A-I      intronic chr14:103445726(-) A-I      intronic chr14:103445722(-) A-I      intronic chr14:103445719(-) A-I      intronic chr14:103489479(-) A-I      intronic chr14:103445700(-) A-I      intronic chr14:103445125(-) A-I      intronic chr14:103445349(-) A-I      intronic chr14:103445641(-) A-I      intronic chr14:103425283(-) A-I      intronic chr14:103496133(-) A-I      intronic chr14:103445618(-) A-I      intronic chr14:103445615(-) A-I      intronic chr14:103445306(-) A-I      intronic chr14:103445297(-) A-I      intronic chr14:103495705(-) A-I      intronic chr14:103497318(-) A-I      intronic chr14:103425442(-) A-I      intronic chr14:103495742(-) A-I      intronic chr14:103496951(-) A-I      intronic chr14:103496957(-) A-I      intronic chr14:103445122(-) A-I      intronic chr14:103496964(-) A-I      intronic chr14:103499130(-) A-I      intronic chr14:103428018(-) A-I      intronic chr14:103506447(-) A-I      intronic chr14:103431370(-) A-I      intronic chr14:103426843(-) A-I      intronic chr14:103432237(-) A-I      intronic chr14:103446587(-) A-I      intronic chr14:103516214(-) A-I      intronic chr14:103496921(-) A-I      intronic chr14:103409536(-) A-I      intronic chr14:103432231(-) A-I      intronic chr14:103409535(-) A-I      intronic chr14:103445686(-) A-I      intronic chr14:103461708(-) A-I      intronic chr14:103432212(-) A-I      intronic chr14:103432211(-) A-I      intronic chr14:103500990(-) A-I      intronic chr14:103445713(-) A-I      intronic chr14:103431495(-) A-I      intronic chr14:103431438(-) A-I      intronic chr14:103445178(-) A-I      intronic chr14:103403080(-) A-I      intronic chr14:103497212(-) A-I      intronic chr14:103431435(-) A-I      intronic chr14:103463073(-) A-I      intronic chr14:103431541(-) A-I      intronic chr14:103429078(-) A-I      intronic chr14:103501111(-) A-I      intronic chr14:103428019(-) A-I      intronic chr14:103501921(-) A-I      intronic chr14:103429049(-) A-I      intronic chr14:103428073(-) A-I      intronic chr14:103412424(-) A-I      intronic chr14:103427812(-) A-I      intronic chr14:103427463(-) A-I      intronic chr14:103513473(-) A-I      intronic chr14:103461546(-) A-I      intronic chr14:103425260(-) A-I      intronic chr14:103520473(-) A-I      intronic chr14:103427395(-) A-I      intronic chr14:103463066(-) A-I      intronic chr14:103488842(-) A-I      intronic chr14:103481822(-) A-I      intronic chr14:103463113(-) A-I      intronic chr14:103521700(-) A-I      intronic chr14:103520474(-) A-I      intronic chr14:103519597(-) A-I      intronic chr14:103519482(-) A-I      intronic chr14:103519430(-) A-I      intronic chr14:103519428(-) A-I      intronic chr14:103517037(-) A-I      intronic chr14:103517032(-) A-I      intronic chr14:103516277(-) A-I      intronic chr14:103514194(-) A-I      intronic chr14:103425282(-) A-I      intronic chr14:103518372(-) A-I      intronic chr14:103461666(-) A-I      intronic chr14:103501933(-) A-I      intronic chr14:103445222(-) A-I      intronic chr14:103431442(-) A-I      intronic chr14:103516926(-) A-I      intronic chr14:103403098(-) A-I      intronic chr14:103445151(-) A-I      intronic chr14:103463097(-) A-I      intronic chr14:103445200(-) A-I      intronic chr14:103432263(-) A-I      intronic chr14:103504618(-) A-I      intronic chr14:103503769(-) A-I      intronic chr14:103499155(-) A-I      intronic chr14:103445232(-) A-I      intronic chr14:103461623(-) A-I      intronic chr14:103461588(-) A-I      intronic chr14:103503282(-) A-I      intronic chr14:103503768(-) A-I      intronic chr14:103513002(-) A-I      intronic chr14:103428117(-) A-I      intronic chr14:103454193(-) A-I      intronic chr14:103445421(-) A-I      intronic chr14:103501015(-) A-I      intronic chr14:103517025(-) A-I      intronic chr14:103516253(-) A-I      intronic chr14:103428152(-) A-I      intronic chr14:103446573(-) A-I      intronic chr14:103425658(-) A-I      intronic chr14:103493011(-) A-I      intronic chr14:103445687(-) A-I      intronic chr14:103446708(-) A-I      intronic chr14:103455975(-) A-I      intronic chr14:103517072(-) A-I      intronic chr14:103431441(-) A-I      intronic chr14:103429150(-) A-I      intronic chr14:103514097(-) A-I      intronic chr14:103506944(-) A-I      intronic chr14:103491910(-) A-I      intronic chr14:103514193(-) A-I      intronic chr14:103459440(-) A-I      intronic chr14:103432131(-) A-I      intronic chr14:103425551(-) A-I      intronic chr14:103502244(-) A-I      intronic chr14:103518379(-) A-I      intronic chr14:103513365(-) A-I      intronic chr14:103501594(-) A-I      intronic chr14:103425198(-) A-I      intronic chr14:103516175(-) A-I      intronic chr14:103482083(-) A-I      intronic chr14:103513982(-) A-I      intronic chr14:103482082(-) A-I      intronic chr14:103516188(-) A-I      intronic chr14:103496911(-) A-I      intronic chr14:103425209(-) A-I      intronic chr14:103519442(-) A-I      intronic chr14:103520316(-) A-I      intronic chr14:103488796(-) A-I      intronic chr14:103445126(-) A-I      intronic chr14:103487679(-) A-I      intronic chr14:103445187(-) A-I      intronic chr14:103501767(-) A-I      intronic chr14:103511090(-) A-I      intronic chr14:103405103(-) A-I      intronic chr14:103501477(-) A-I      intronic chr14:103511352(-) A-I      intronic chr14:103431558(-) A-I      intronic chr14:103462987(-) A-I      intronic chr14:103445742(-) A-I      intronic chr14:103520254(-) A-I      intronic chr14:103513455(-) A-I      intronic chr14:103489707(-) A-I      intronic chr14:103489705(-) A-I      intronic chr14:103476402(-) A-I      intronic chr14:103431335(-) A-I      intronic chr14:103488791(-) A-I      intronic chr14:103445308(-) A-I      intronic chr14:103462984(-) A-I      intronic chr14:103445335(-) A-I      intronic chr14:103423103(-) A-I      intronic chr14:103513545(-) A-I      intronic chr14:103445196(-) A-I      intronic chr14:103519585(-) A-I      intronic chr14:103506661(-) A-I      intronic chr14:103403343(-) A-I      intronic chr14:103517000(-) A-I      intronic chr14:103499226(-) A-I      intronic chr14:103431542(-) A-I      intronic chr14:103497291(-) A-I      intronic chr14:103519443(-) A-I      intronic chr14:103513186(-) A-I      intronic chr14:103513187(-) A-I      intronic chr14:103445358(-) A-I      intronic chr14:103448088(-) A-I      intronic chr14:103499107(-) A-I      intronic chr14:103431427(-) A-I      intronic chr14:103445822(-) A-I      intronic chr14:103445816(-) A-I      intronic chr14:103425451(-) A-I      intronic chr14:103461893(-) A-I      intronic chr14:103471039(-) A-I      intronic chr14:103425377(-) A-I      intronic chr14:103427929(-) A-I      intronic chr14:103426287(-) A-I      intronic chr14:103461644(-) A-I      intronic chr14:103508881(-) A-I      intronic chr14:103445613(-) A-I      intronic chr14:103461584(-) A-I      intronic chr14:103500671(-) A-I      intronic chr14:103409590(-) A-I      intronic chr14:103445310(-) A-I      intronic chr14:103501876(-) A-I      intronic chr14:103513477(-) A-I      intronic chr14:103503813(-) A-I      intronic chr14:103456113(-) A-I      intronic chr14:103479058(-) A-I      intronic chr14:103445743(-) A-I      intronic chr14:103425229(-) A-I      intronic chr14:103445257(-) A-I      intronic chr14:103432232(-) A-I      intronic chr14:103446747(-) A-I      intronic chr14:103496134(-) A-I      intronic chr14:103463089(-) A-I      intronic chr14:103520280(-) A-I      intronic chr14:103504178(-) A-I      intronic chr14:103461600(-) A-I      intronic chr14:103459462(-) A-I      intronic chr14:103516189(-) A-I      intronic chr14:103471042(-) A-I      intronic chr14:103477825(-) A-I      intronic chr14:103519854(-) A-I      intronic chr14:103432111(-) A-I      intronic chr14:103425259(-) A-I      intronic chr14:103464463(-) A-I      intronic chr14:103513428(-) A-I      intronic chr14:103517018(-) A-I      intronic chr14:103431355(-) A-I      intronic chr14:103501511(-) A-I      intronic chr14:103426847(-) A-I      intronic chr14:103499177(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CDC42BPB	chr14:103431335(-) A-I intron -    15342557 chr14:103431355(-) A-I intron -    15342557 chr14:103431370(-) A-I intron -    15342557 chr14:103431427(-) A-I intron -    15342557 chr14:103431441(-) A-I intron -    15342557 chr14:103431442(-) A-I intron -    15342557 chr14:103431558(-) A-I intron -    15342557 chr14:103432131(-) A-I intron -    15342557 chr14:103432153(-) A-I intron -    15342557 chr14:103432232(-) A-I intron -    15342557 chr14:103432263(-) A-I intron -    15342557 chr14:103445257(-) A-I intron -    21960545 chr14:103445686(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDC42BPB	chr14:103398759-103398760(-) m6A 3'UTR       27773535 chr14:103398769-103398770(-) m6A 3'UTR       27773535 chr14:103399005-103399006(-) m6A 3'UTR       24284625//27773535//22575960 chr14:103399155-103399156(-) m6A 3'UTR       24284625 chr14:103399338-103399339(-) m6A 3'UTR       - chr14:103399475-103399476(-) m6A 3'UTR       - chr14:103399488-103399489(-) m6A 3'UTR       - chr14:103399577-103399578(-) m6A 3'UTR       24981863 chr14:103399635-103399636(-) m6A 3'UTR       24284625//24981863 chr14:103399646-103399647(-) m6A 3'UTR       24284625//24981863//22575960 chr14:103399685-103399686(-) m6A 3'UTR       24284625//24981863//22575960 chr14:103399695-103399696(-) m6A 3'UTR       24284625//24981863//22575960 chr14:103399726-103399727(-) m6A 3'UTR       24284625//24981863//22575960 chr14:103399806-103399807(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960 chr14:103399864-103399865(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960 chr14:103399919-103399920(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27371828 chr14:103399931-103399932(-) Gm 3'UTR       - chr14:103399987-103399988(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27371828//22575960 chr14:103400159-103400160(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960 chr14:103400169-103400170(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960 chr14:103404453-103404454(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960 chr14:103404459-103404460(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960 chr14:103404671-103404672(-) m6A CDS       24284625//24209618//24981863//27773535//22575960 chr14:103405956-103405957(-) m6A CDS       24284625//24981863//26404942//27773535 chr14:103406049-103406050(-) m6A CDS       24284625//24981863//26404942//27773535 chr14:103406180-103406181(-) m6A CDS       24284625//24981863//26404942//27773535 chr14:103406262-103406263(-) m6A CDS//exon       24284625//27773535 chr14:103406453-103406454(-) m6A CDS//exon       24284625 chr14:103406580-103406581(-) m6A CDS//exon       22575960 chr14:103406938-103406939(-) m6A exon//intron       24981863 chr14:103406943-103406944(-) m6A exon//intron       24981863 chr14:103410283-103410284(-) Am CDS//exon       - chr14:103410289-103410290(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:103410300-103410301(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:103410415-103410416(-) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr14:103410484-103410485(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:103410619-103410620(-) m6A CDS//exon       24284625//25456834//24981863//26404942//22575960//22608085 chr14:103410662-103410663(-) m6A CDS//exon       24284625//25456834//24981863//26404942//22575960//22608085 chr14:103410736-103410737(-) m6A CDS//exon       24284625//24981863//22575960 chr14:103410788-103410789(-) Cm CDS//exon       - chr14:103429465-103429466(-) m6A CDS       24981863 chr14:103429488-103429489(-) m6A CDS       24981863//27773536 chr14:103430949-103430950(-) m6A CDS       27773536//22575960 chr14:103432623-103432624(-) m6A CDS       27773536//22575960 chr14:103433468-103433469(-) m6A CDS       24981863//27773535 chr14:103433486-103433487(-) m6A CDS       24981863//27773535 chr14:103434617-103434618(-) m6A CDS       24981863//27773535 chr14:103436527-103436528(-) m6A CDS       24209618//27773535//27773536//22575960 chr14:103438340-103438341(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr14:103438453-103438454(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr14:103440425-103440426(-) m6A CDS       24209618//24981863//27773535//27371828//27773536//22575960 chr14:103440455-103440456(-) m6A CDS       24209618//24981863//27773535//27371828//22575960 chr14:103440479-103440480(-) m6A CDS       24209618//24981863//27773535//27371828//22575960 chr14:103442082-103442083(-) m6A CDS       24209618//24981863//27773535//22575960 chr14:103442128-103442129(-) m6A CDS       24981863//27773535//22575960 chr14:103442253-103442254(-) m6A CDS       24981863//22575960 chr14:103442308-103442309(-) m6A CDS       24981863 chr14:103449899-103449900(-) m6A CDS       27773535 chr14:103449918-103449919(-) m6A CDS       27773535 chr14:103523564-103523565(-) m6A 5'UTR       24209618//25456834//27773536 chr14:103523696-103523697(-) m6A 5'UTR       24209618//25456834//27773536//22575960 chr14:103523719-103523720(-) m6A 5'UTR       24209618//25456834//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1307-5p	Exosome Plasma     23663360 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Blood|B lymphoblastoid cells|Chronic lymphocytic leukemia cells|Endothelial cells|Kidney tissue|Lymphoma tissue     - Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	CDC42BPB	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1307-5p
Interactor2: CDC42BPB

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).