Basic Information:

  VIRBase ID:  

HHID00016898

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          TUSC1:  NM_001004125     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	TUSC1
miRBase Accession/Entrez ID	MIMAT0019058	286319
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CCDC89B//TSG-9//TSG9

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TUSC1	chr9:25677319-25677320(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:25677340-25677341(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:25677358-25677359(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:25677373-25677374(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:25677382-25677383(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:25677471-25677472(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr9:25677535-25677536(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr9:25677565-25677566(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr9:25677708-25677709(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr9:25677734-25677735(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr9:25677759-25677760(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr9:25677776-25677777(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr9:25677888-25677889(-) m6A CDS       24284625//24209618//25456834//24981863//27773536//22575960//22608085 chr9:25677903-25677904(-) m6A CDS       24284625//24209618//25456834//24981863//27773536//22575960//22608085 chr9:25677999-25678000(-) m6A CDS       24284625//24209618//25456834//24981863//27773536//22575960//22608085 chr9:25678020-25678021(-) m6A CDS       24284625//24209618//25456834//24981863//27773536//22575960//22608085 chr9:25678071-25678072(-) m6A CDS       24284625//24209618//25456834//27773536//22575960//22608085 chr9:25678313-25678314(-) m6A CDS       24209618//27773536 chr9:25678376-25678377(-) m6A 5'UTR       24209618//25456834//24981863//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	TUSC1	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: TUSC1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).