Detail Information

Basic Information:


  VIRBase ID:  

HHID00016890

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:           ZNF780A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4521 ZNF780A
miRBase
Accession/Entrez ID		 MIMAT0019058 284323
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ZNF780

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4521
rs1011991709 chr17:8186962    G/A
rs1011991709 chr17:8186962    G/C
rs1041768648 chr17:8186965    C/T
rs1056190393 chr17:8186959    C/A
rs1231036635 chr17:8186958    T/A
rs1231036635 chr17:8186958    T/G
rs1316923680 chr17:8186964    G/A
rs1316923680 chr17:8186964    G/C
rs1316923680 chr17:8186964    G/T
rs1365122718 chr17:8186957    G/C
rs559116584 chr17:8186963    T/C
rs559116584 chr17:8186963    T/G
rs561824123 chr17:8186969    G/A
rs768576971 chr17:8186966    T/A
rs768576971 chr17:8186966    T/C
rs776348878 chr17:8186967    C/A
rs893173803 chr17:8186960    C/G
rs893173803 chr17:8186960    C/T
rs999343007 chr17:8186968    A/G
rs1310598293 chr17:8186951    A/G
rs928871091 chr17:8186953    G/A
rs928871091 chr17:8186953    G/C
rs937623219 chr17:8186954    G/A
rs953552065 chr17:8186949    C/A
rs953552065 chr17:8186949    C/G
rs953552065 chr17:8186949    C/T
rs962385560 chr17:8186955    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZNF780A
chr19:40591778(-) A-I      intronic
chr19:40591705(-) A-I      intronic
chr19:40574153(-) A-I      intronic
chr19:40591730(-) A-I      intronic
chr19:40592707(-) A-I      intronic
chr19:40592734(-) A-I      intronic
chr19:40573847(-) A-I      intronic
chr19:40574121(-) A-I      intronic
chr19:40591687(-) A-I      intronic
chr19:40589361(-) A-I      intronic
chr19:40592869(-) A-I      intronic
chr19:40592792(-) A-I      intronic
chr19:40592672(-) A-I      intronic
chr19:40591621(-) A-I      intronic
chr19:40574129(-) A-I      intronic
chr19:40589485(-) A-I      intronic
chr19:40591639(-) A-I      intronic
chr19:40589380(-) A-I      intronic
chr19:40591704(-) A-I      intronic
chr19:40592789(-) A-I      intronic
chr19:40574190(-) A-I      intronic
chr19:40589471(-) A-I      intronic
chr19:40574081(-) A-I      intronic
chr19:40591532(-) A-I      intronic
chr19:40574146(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZNF780A
chr19:40575645-40575646(-) m6A 3'UTR       24981863//27773535
chr19:40575657-40575658(-) m6A 3'UTR       24981863//27773535
chr19:40579646-40579647(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr19:40579667-40579668(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr19:40579736-40579737(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr19:40579880-40579881(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr19:40579899-40579900(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr19:40579927-40579928(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr19:40579983-40579984(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr19:40580011-40580012(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr19:40580048-40580049(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr19:40580122-40580123(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr19:40580179-40580180(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr19:40580262-40580263(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr19:40580346-40580347(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr19:40580383-40580384(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr19:40580450-40580451(-) m6A CDS//intron       24284625//24981863//27773535//27371828//22608085
chr19:40580515-40580516(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr19:40580599-40580600(-) m6A CDS//intron       24284625//27773535//22608085
chr19:40580683-40580684(-) m6A CDS//intron       24981863//27773535//22608085
chr19:40580767-40580768(-) m6A CDS//intron       25456834//24981863//27773535//22608085
chr19:40580784-40580785(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr19:40580815-40580816(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr19:40580918-40580919(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr19:40580962-40580963(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr19:40581019-40581020(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085
chr19:40581103-40581104(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr19:40581140-40581141(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr19:40581187-40581188(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr19:40581206-40581207(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr19:40581271-40581272(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr19:40581355-40581356(-) m6A CDS//intron       24981863//27773535//22608085
chr19:40581382-40581383(-) m6A CDS//intron       24981863//27773535//22608085
chr19:40581439-40581440(-) m6A CDS//intron       24981863//27773535//22608085
chr19:40581523-40581524(-) m6A CDS//intron       24981863//27773535//22608085
chr19:40581560-40581561(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr19:40581607-40581608(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr19:40581626-40581627(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr19:40581691-40581692(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr19:40581775-40581776(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr19:40581859-40581860(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085
chr19:40581907-40581908(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr19:40581961-40581962(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr19:40581973-40581974(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr19:40582045-40582046(-) m6A CDS       24284625//24981863//27773535//22608085
chr19:40582096-40582097(-) m6A CDS       24284625//27773535//22608085
chr19:40587743-40587744(-) m6A CDS       27773535//22608085
chr19:40587804-40587805(-) m6A CDS       27773535
chr19:40589040-40589041(-) m6A CDS       27773535
chr19:40589068-40589069(-) m6A 5'UTR//CDS       27773535
chr19:40596118-40596119(-) m6A 5'UTR//intron       24981863
chr19:40596199-40596200(-) m6A 5'UTR//intron       24981863
chr19:40596693-40596694(-) m6A 5'UTR//intron       25456834//24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4521
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
ZNF780A
Chromatin K562 cells     -
Exosome Blood     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4521
Interactor2: ZNF780A

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

Starting a new search, please wait ...