Basic Information:

  VIRBase ID:  

HHID00016880

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          PROSER2:  NM_153256     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	PROSER2
miRBase Accession/Entrez ID	MIMAT0019058	254427
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C10orf47

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PROSER2	chr10:11890910(+) A-I      intronic chr10:11900059(+) A-I      intronic chr10:11888826(+) A-I      intronic chr10:11890906(+) A-I      intronic chr10:11888877(+) A-I      intronic chr10:11900037(+) A-I      intronic chr10:11899545(+) A-I      intronic chr10:11900038(+) A-I      intronic chr10:11899584(+) A-I      intronic chr10:11900060(+) A-I      intronic chr10:11900063(+) A-I      intronic chr10:11899990(+) A-I      intronic chr10:11900073(+) A-I      intronic chr10:11899582(+) A-I      intronic chr10:11891114(+) A-I      intronic chr10:11891130(+) A-I      intronic chr10:11871423(+) A-I      intronic chr10:11871522(+) A-I      intronic chr10:11899601(+) A-I      intronic chr10:11896376(+) A-I      intronic chr10:11899558(+) A-I      intronic chr10:11899548(+) A-I      intronic chr10:11899650(+) A-I      intronic chr10:11906687(+) A-I      intronic chr10:11895518(+) A-I      intronic chr10:11896493(+) A-I      intronic chr10:11899566(+) A-I      intronic chr10:11899567(+) A-I      intronic chr10:11882738(+) A-I      intronic chr10:11891092(+) A-I      intronic chr10:11881704(+) A-I      intronic chr10:11899568(+) A-I      intronic chr10:11899665(+) A-I      intronic chr10:11899449(+) A-I      intronic chr10:11891107(+) A-I      intronic chr10:11871489(+) A-I      intronic chr10:11869911(+) A-I      intronic chr10:11900741(+) A-I      intronic chr10:11871402(+) A-I      intronic chr10:11882737(+) A-I      intronic chr10:11899653(+) A-I      intronic chr10:11899448(+) A-I      intronic chr10:11899624(+) A-I      intronic chr10:11899701(+) A-I      intronic chr10:11899654(+) A-I      intronic chr10:11896407(+) A-I      intronic chr10:11899656(+) A-I      intronic chr10:11871520(+) A-I      intronic chr10:11899655(+) A-I      intronic chr10:11881697(+) A-I      intronic chr10:11881713(+) A-I      intronic chr10:11899659(+) A-I      intronic chr10:11906681(+) A-I      intronic chr10:11876479(+) A-I      intronic chr10:11882768(+) A-I      intronic chr10:11869929(+) A-I      intronic chr10:11871377(+) A-I      intronic chr10:11874890(+) A-I      intronic chr10:11882762(+) A-I      intronic chr10:11886180(+) A-I      intronic chr10:11874865(+) A-I      intronic chr10:11876094(+) A-I      intronic chr10:11871449(+) A-I      intronic chr10:11882765(+) A-I      intronic chr10:11889025(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PROSER2	chr10:11865380-11865381(+) m6A exon       24284625//25456834//24981863 chr10:11865435-11865436(+) m6A 5'UTR//exon       24284625//25456834//24981863 chr10:11873767-11873768(+) m6A 5'UTR//intron       24284625 chr10:11873781-11873782(+) m6A 5'UTR//intron       24284625 chr10:11873806-11873807(+) m6A 5'UTR//intron       24284625 chr10:11894065-11894066(+) m6A 5'UTR//exon       24284625 chr10:11894116-11894117(+) m6A CDS//exon       24284625 chr10:11894122-11894123(+) m6A CDS//exon       24284625 chr10:11908614-11908615(+) m6A CDS//exon       24284625 chr10:11908769-11908770(+) m6A CDS//exon       24284625 chr10:11911519-11911520(+) m6A CDS       24284625 chr10:11911532-11911533(+) m6A CDS       24284625 chr10:11911548-11911549(+) m6A CDS       24284625//25456834//24981863 chr10:11911565-11911566(+) m6A CDS       24284625//25456834//24981863 chr10:11911654-11911655(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863 chr10:11911775-11911776(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr10:11911806-11911807(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr10:11911904-11911905(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr10:11912277-11912278(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr10:11912292-11912293(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr10:11912607-11912608(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:11912657-11912658(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:11912684-11912685(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:11912740-11912741(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:11913710-11913711(+) Tm 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	PROSER2	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: PROSER2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).