Basic Information:

  VIRBase ID:  

HHID00016878

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          LCLAT1:  NM_001304446     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	LCLAT1
miRBase Accession/Entrez ID	MIMAT0019058	253558
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	1AGPAT8//AGPAT8//ALCAT1//HSRG1849//LYCAT//UNQ1849

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LCLAT1	chr2:30767521(+) A-I      intronic chr2:30761244(+) A-I      intronic chr2:30761238(+) A-I      intronic chr2:30702195(+) A-I      intronic chr2:30678655(+) A-I      intronic chr2:30677458(+) A-I      intronic chr2:30677360(+) A-I      intronic chr2:30811612(+) A-I      intronic chr2:30811584(+) A-I      intronic chr2:30811568(+) A-I      intronic chr2:30811528(+) A-I      intronic chr2:30811506(+) A-I      intronic chr2:30811483(+) A-I      intronic chr2:30811546(+) A-I      intronic chr2:30852273(+) A-I      intronic chr2:30852230(+) A-I      intronic chr2:30852206(+) A-I      intronic chr2:30852315(+) A-I      intronic chr2:30852279(+) A-I      intronic chr2:30830985(+) A-I      intronic chr2:30852306(+) A-I      intronic chr2:30852328(+) A-I      intronic chr2:30852305(+) A-I      intronic chr2:30852197(+) A-I      intronic chr2:30852332(+) A-I      intronic chr2:30852274(+) A-I      intronic chr2:30852270(+) A-I      intronic chr2:30852299(+) A-I      intronic chr2:30852347(+) A-I      intronic chr2:30852170(+) A-I      intronic chr2:30852179(+) A-I      intronic chr2:30702165(+) A-I      intronic chr2:30678614(+) A-I      intronic chr2:30703299(+) A-I      intronic chr2:30808989(+) A-I      intronic chr2:30852275(+) A-I      intronic chr2:30677544(+) A-I      intronic chr2:30703266(+) A-I      intronic chr2:30746614(+) A-I      intronic chr2:30808963(+) A-I      intronic chr2:30852171(+) A-I      intronic chr2:30852240(+) A-I      intronic chr2:30809058(+) A-I      intronic chr2:30831025(+) A-I      intronic chr2:30677375(+) A-I      intronic chr2:30753444(+) A-I      intronic chr2:30811475(+) A-I      intronic chr2:30762169(+) A-I      intronic chr2:30830986(+) A-I      intronic chr2:30701479(+) A-I      intronic chr2:30684362(+) A-I      intronic chr2:30678696(+) A-I      intronic chr2:30753515(+) A-I      intronic chr2:30753876(+) A-I      intronic chr2:30831011(+) A-I      intronic chr2:30761380(+) A-I      intronic chr2:30811606(+) A-I      intronic chr2:30856387(+) A-I      intronic chr2:30706164(+) A-I      intronic chr2:30761332(+) A-I      intronic chr2:30779838(+) A-I      intronic chr2:30796971(+) A-I      intronic chr2:30701424(+) A-I      intronic chr2:30762172(+) A-I      intronic chr2:30763579(+) A-I      intronic chr2:30702149(+) A-I      intronic chr2:30761892(+) A-I      intronic chr2:30678736(+) A-I      intronic chr2:30761965(+) A-I      intronic chr2:30678624(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	LCLAT1	chr2:30829248(+) A-I intron -    15342557   //15258596 chr2:30829686(+) A-I intron -    15342557   //15258596 chr2:30830087(+) A-I intron -    15342557   //15258596 chr2:30830109(+) A-I intron -    15342557   //15258596 chr2:30830113(+) A-I intron -    15342557   //15258596 chr2:30830154(+) A-I intron -    15342557   //15258596 chr2:30830985(+) A-I intron -    15342557 chr2:30830986(+) A-I intron -    15342557 chr2:30831000(+) A-I intron -    15342557 chr2:30831004(+) A-I intron -    15342557 chr2:30831011(+) A-I intron -    15342557 chr2:30831025(+) A-I intron -    15342557 chr2:30852170(+) A-I intron -    22028664 chr2:30852171(+) A-I intron -    22028664 chr2:30852179(+) A-I intron -    22028664 chr2:30852197(+) A-I intron -    22028664 chr2:30852206(+) A-I intron -    22028664 chr2:30852230(+) A-I intron -    22028664 chr2:30852240(+) A-I intron -    22028664 chr2:30852264(+) A-I intron -    22028664 chr2:30852270(+) A-I intron -    22028664 chr2:30852273(+) A-I intron -    22028664 chr2:30852274(+) A-I intron -    22028664 chr2:30852275(+) A-I intron -    22028664 chr2:30852279(+) A-I intron -    22028664 chr2:30852299(+) A-I intron -    22028664 chr2:30852305(+) A-I intron -    22028664 chr2:30852306(+) A-I intron -    22028664 chr2:30852315(+) A-I intron -    22028664 chr2:30852328(+) A-I intron -    22028664 chr2:30852332(+) A-I intron -    22028664 chr2:30852347(+) A-I intron -    22028664 chr2:30677375(+) A-G intron -    22484847 chr2:30677584(+) T-G intron -    22484847 chr2:30678629(+) A-G intron -    22484847 chr2:30701422(+) A-G intron -    22484847 chr2:30701424(+) A-G intron -    22484847 chr2:30701433(+) A-G intron -    22484847 chr2:30701437(+) A-G intron -    22484847 chr2:30703266(+) A-G intron -    22484847 chr2:30808921(+) A-G intron -    22484847 chr2:30811475(+) A-G intron -    22484847 chr2:30811536(+) A-G intron -    22484847 chr2:30811606(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LCLAT1	chr2:30670262-30670263(+) m6A 5'UTR//exon//intron       24981863 chr2:30829497-30829498(+) m6A 3'UTR//intron       22608085 chr2:30829531-30829532(+) m6A 3'UTR//intron       22608085 chr2:30829616-30829617(+) m6A 3'UTR//intron       22608085 chr2:30829644-30829645(+) m6A 3'UTR//intron       22608085 chr2:30829660-30829661(+) m6A 3'UTR//intron       22608085 chr2:30829739-30829740(+) m6A 3'UTR//intron       22608085 chr2:30829745-30829746(+) m6A 3'UTR//intron       22608085 chr2:30829763-30829764(+) m6A 3'UTR//intron       22608085 chr2:30829791-30829792(+) m6A 3'UTR//intron       22608085 chr2:30829797-30829798(+) m6A 3'UTR//intron       22608085 chr2:30829818-30829819(+) m6A 3'UTR//intron       22608085 chr2:30829837-30829838(+) m6A 3'UTR//intron       22608085 chr2:30863066-30863067(+) m6A 3'UTR//CDS//exon       24981863 chr2:30863111-30863112(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr2:30863135-30863136(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr2:30863226-30863227(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr2:30863256-30863257(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr2:30863299-30863300(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr2:30863409-30863410(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22608085 chr2:30863424-30863425(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22608085 chr2:30863451-30863452(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22608085 chr2:30863509-30863510(+) m6A 3'UTR//exon       24981863//22608085 chr2:30863739-30863740(+) m6A 3'UTR//exon       24981863 chr2:30863767-30863768(+) m6A 3'UTR//exon       24981863 chr2:30863803-30863804(+) m6A 3'UTR//exon       24981863 chr2:30864085-30864086(+) m6A 3'UTR       24981863 chr2:30864119-30864120(+) m6A 3'UTR       24981863 chr2:30864125-30864126(+) m6A 3'UTR       24981863 chr2:30864159-30864160(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	LCLAT1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: LCLAT1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).