Basic Information:

  VIRBase ID:  

HHID00016855

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          ADAMTS16:  NM_139056     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	ADAMTS16
miRBase Accession/Entrez ID	MIMAT0019058	170690
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ADAMTS16s

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ADAMTS16	chr5:5225539(+) A-I      intronic chr5:5225540(+) A-I      intronic chr5:5225560(+) A-I      intronic chr5:5225563(+) A-I      intronic chr5:5225555(+) A-I      intronic chr5:5225726(+) A-I      intronic chr5:5308988(+) A-I      intronic chr5:5206284(+) A-I      intronic chr5:5225665(+) A-I      intronic chr5:5225595(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ADAMTS16	chr5:5223488-5223489(+) m6A 3'UTR//intron       24209618//24981863 chr5:5223500-5223501(+) m6A 3'UTR//intron       24209618//25456834//24981863 chr5:5223507-5223508(+) m6A 3'UTR//intron       24209618//25456834//24981863 chr5:5223546-5223547(+) m6A 3'UTR//intron       24209618//25456834//24981863 chr5:5223563-5223564(+) m6A 3'UTR//intron       24209618//25456834//24981863 chr5:5223577-5223578(+) m6A 3'UTR//intron       24209618//25456834//24981863 chr5:5223584-5223585(+) m6A 3'UTR//intron       25456834//24981863 chr5:5223593-5223594(+) m6A 3'UTR//intron       25456834//24981863 chr5:5223633-5223634(+) m6A 3'UTR//intron       25456834//24981863 chr5:5319429-5319430(+) m6A 3'UTR       - chr5:5319487-5319488(+) m6A 3'UTR       25456834 chr5:5319579-5319580(+) m6A 3'UTR       25456834//24981863 chr5:5319593-5319594(+) m6A 3'UTR       25456834//24981863 chr5:5319649-5319650(+) m6A 3'UTR       25456834//24981863 chr5:5319814-5319815(+) m6A 3'UTR       25456834//24981863 chr5:5319866-5319867(+) m6A 3'UTR       25456834//24981863 chr5:5319884-5319885(+) m6A 3'UTR       25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	ADAMTS16	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: ADAMTS16

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).