Detail Information

Basic Information:


  VIRBase ID:  

HHID00016815

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:           PABPC5:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4521 PABPC5
miRBase
Accession/Entrez ID
MIMAT0019058 140886
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PABP5

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4521
rs1011991709 chr17:8186962    G/A
rs1011991709 chr17:8186962    G/C
rs1041768648 chr17:8186965    C/T
rs1056190393 chr17:8186959    C/A
rs1231036635 chr17:8186958    T/A
rs1231036635 chr17:8186958    T/G
rs1316923680 chr17:8186964    G/A
rs1316923680 chr17:8186964    G/C
rs1316923680 chr17:8186964    G/T
rs1365122718 chr17:8186957    G/C
rs559116584 chr17:8186963    T/C
rs559116584 chr17:8186963    T/G
rs561824123 chr17:8186969    G/A
rs768576971 chr17:8186966    T/A
rs768576971 chr17:8186966    T/C
rs776348878 chr17:8186967    C/A
rs893173803 chr17:8186960    C/G
rs893173803 chr17:8186960    C/T
rs999343007 chr17:8186968    A/G
rs1310598293 chr17:8186951    A/G
rs928871091 chr17:8186953    G/A
rs928871091 chr17:8186953    G/C
rs937623219 chr17:8186954    G/A
rs953552065 chr17:8186949    C/A
rs953552065 chr17:8186949    C/G
rs953552065 chr17:8186949    C/T
rs962385560 chr17:8186955    A/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PABPC5
chrX:90690805-90690806(+) m6A CDS//intron       25456834
chrX:90690836-90690837(+) m6A CDS//intron       25456834
chrX:90690910-90690911(+) m6A CDS//intron       25456834
chrX:90690916-90690917(+) m6A CDS//intron       24209618//25456834
chrX:90690928-90690929(+) m6A CDS//intron       24209618//25456834
chrX:90690967-90690968(+) m6A CDS//intron       24209618//25456834
chrX:90691149-90691150(+) m6A CDS       24209618//25456834//24981863
chrX:90691189-90691190(+) m6A CDS       24209618//25456834//24981863
chrX:90691217-90691218(+) m6A CDS       24209618//25456834//24981863
chrX:90691226-90691227(+) m6A CDS       24209618//25456834//24981863
chrX:90691317-90691318(+) m6A CDS       24209618//25456834//24981863
chrX:90691348-90691349(+) m6A CDS       24209618//25456834//24981863
chrX:90691498-90691499(+) m6A CDS       24209618//25456834//24981863
chrX:90691509-90691510(+) m6A CDS       24209618//25456834//24981863
chrX:90691526-90691527(+) m6A CDS       24209618//25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4521
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
PABPC5
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4521
Interactor2: PABPC5

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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