Detail Information

Basic Information:


  VIRBase ID:  

HHID00016810

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:           ADAT2:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4521 ADAT2
miRBase
Accession/Entrez ID		 MIMAT0019058 134637
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DEADC1//dJ20N2//dJ20N2.1//TAD2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4521
rs1011991709 chr17:8186962    G/A
rs1011991709 chr17:8186962    G/C
rs1041768648 chr17:8186965    C/T
rs1056190393 chr17:8186959    C/A
rs1231036635 chr17:8186958    T/A
rs1231036635 chr17:8186958    T/G
rs1316923680 chr17:8186964    G/A
rs1316923680 chr17:8186964    G/C
rs1316923680 chr17:8186964    G/T
rs1365122718 chr17:8186957    G/C
rs559116584 chr17:8186963    T/C
rs559116584 chr17:8186963    T/G
rs561824123 chr17:8186969    G/A
rs768576971 chr17:8186966    T/A
rs768576971 chr17:8186966    T/C
rs776348878 chr17:8186967    C/A
rs893173803 chr17:8186960    C/G
rs893173803 chr17:8186960    C/T
rs999343007 chr17:8186968    A/G
rs1310598293 chr17:8186951    A/G
rs928871091 chr17:8186953    G/A
rs928871091 chr17:8186953    G/C
rs937623219 chr17:8186954    G/A
rs953552065 chr17:8186949    C/A
rs953552065 chr17:8186949    C/G
rs953552065 chr17:8186949    C/T
rs962385560 chr17:8186955    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ADAT2
chr6:143770843(-) A-I      intronic
chr6:143770842(-) A-I      intronic
chr6:143770844(-) A-I      intronic
chr6:143770848(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ADAT2
chr6:143764631(-) T-C intron -    22484847
chr6:143764797(-) T-C intron -    22484847
chr6:143764980(-) T-C intron -    22484847
chr6:143764981(-) C-T intron -    22484847
chr6:143764982(-) A-C intron -    22484847
chr6:143764983(-) A-T intron -    22484847
chr6:143764984(-) T-A intron -    22484847
chr6:143770847(-) A-G intron -    22484847
chr6:143771159(-) A-G intron -    22484847
chr6:143771171(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ADAT2
chr6:143746948-143746949(-) m6A 3'UTR       27773535
chr6:143746967-143746968(-) m6A 3'UTR       27773535
chr6:143747738-143747739(-) m6A 3'UTR       27773535//22608085
chr6:143747757-143747758(-) m6A 3'UTR       27773535//22608085
chr6:143747799-143747800(-) m6A 3'UTR       27773535
chr6:143747846-143747847(-) m6A 3'UTR       27773535
chr6:143747856-143747857(-) m6A 3'UTR       27773535
chr6:143748642-143748643(-) m6A 3'UTR       27773535
chr6:143748705-143748706(-) m6A 3'UTR       27773535//22608085
chr6:143748782-143748783(-) m6A 3'UTR       24981863//27773535//22608085
chr6:143748813-143748814(-) m6A 3'UTR       24981863//27773535//22608085
chr6:143748892-143748893(-) m6A 3'UTR       27773535//22608085
chr6:143748913-143748914(-) m6A 3'UTR       27773535
chr6:143748924-143748925(-) m6A 3'UTR       27773535
chr6:143748971-143748972(-) m6A 3'UTR       27773535
chr6:143749021-143749022(-) m6A 3'UTR       27773535
chr6:143749065-143749066(-) m6A 3'UTR       27773535
chr6:143749092-143749093(-) m6A 3'UTR       27773535//22608085
chr6:143749200-143749201(-) m6A 3'UTR       24981863//27773535//22608085
chr6:143749214-143749215(-) m6A 3'UTR       24981863//27773535//22608085
chr6:143749236-143749237(-) m6A 3'UTR       24981863//27773535//22608085
chr6:143749253-143749254(-) m6A 3'UTR       24981863//27773535//22608085
chr6:143749261-143749262(-) m6A 3'UTR       24981863//27773535//22608085
chr6:143749543-143749544(-) m6A 3'UTR       24981863//22608085
chr6:143749556-143749557(-) m6A 3'UTR       24981863//22608085
chr6:143749580-143749581(-) m6A 3'UTR       24981863//22608085
chr6:143749598-143749599(-) m6A 3'UTR       24981863//22608085
chr6:143749764-143749765(-) m6A CDS       -
chr6:143749775-143749776(-) m6A CDS       -
chr6:143771731-143771732(-) m6A CDS//exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4521
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
ADAT2
Chromatin K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4521
Interactor2: ADAT2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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