Basic Information:

  VIRBase ID:  

HHID00016759

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          EXOC3L2:  NM_001382422     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	EXOC3L2
miRBase Accession/Entrez ID	MIMAT0019058	90332
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	XTP7

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EXOC3L2	chr19:45718393(-) A-I      intronic chr19:45717901(-) A-I      intronic chr19:45717896(-) A-I      intronic chr19:45717887(-) A-I      intronic chr19:45726480(-) A-I      intronic chr19:45716131(-) A-I      3'UTR chr19:45716130(-) A-I      3'UTR chr19:45716122(-) A-I      3'UTR chr19:45716101(-) A-I      3'UTR chr19:45716085(-) A-I      3'UTR chr19:45716077(-) A-I      3'UTR chr19:45716040(-) A-I      3'UTR chr19:45716030(-) A-I      3'UTR chr19:45716024(-) A-I      3'UTR chr19:45716009(-) A-I      3'UTR chr19:45715937(-) A-I      3'UTR chr19:45715890(-) A-I      3'UTR chr19:45726697(-) A-I      intronic chr19:45724695(-) A-I      intronic chr19:45715899(-) A-I      3'UTR chr19:45718248(-) A-I      intronic chr19:45718251(-) A-I      intronic chr19:45718685(-) A-I      intronic chr19:45722558(-) A-I      intronic chr19:45725626(-) A-I      intronic chr19:45725641(-) A-I      intronic chr19:45725982(-) A-I      intronic chr19:45726661(-) A-I      intronic chr19:45726752(-) A-I      intronic chr19:45726761(-) A-I      intronic chr19:45727206(-) A-I      intronic chr19:45727208(-) A-I      intronic chr19:45732136(-) A-I      intronic chr19:45734092(-) A-I      intronic chr19:45729810(-) A-I      intronic chr19:45718230(-) A-I      intronic chr19:45715981(-) A-I      3'UTR chr19:45715896(-) A-I      3'UTR chr19:45716124(-) A-I      3'UTR chr19:45715895(-) A-I      3'UTR chr19:45715985(-) A-I      3'UTR chr19:45715894(-) A-I      3'UTR chr19:45715891(-) A-I      3'UTR chr19:45716057(-) A-I      3'UTR chr19:45720316(-) A-I      intronic chr19:45720408(-) A-I      intronic chr19:45718304(-) A-I      intronic chr19:45723612(-) A-I      intronic chr19:45716034(-) A-I      3'UTR chr19:45716017(-) A-I      3'UTR chr19:45718321(-) A-I      intronic chr19:45718169(-) A-I      intronic chr19:45724845(-) A-I      intronic chr19:45723477(-) A-I      intronic chr19:45718397(-) A-I      intronic chr19:45716153(-) A-I      3'UTR chr19:45715929(-) A-I      3'UTR chr19:45715991(-) A-I      3'UTR chr19:45724677(-) A-I      intronic chr19:45726668(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EXOC3L2	chr19:45723468(-) T-C intron -    22484847 chr19:45723484(-) T-C intron -    22484847 chr19:45723485(-) T-C intron -    22484847

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	EXOC3L2	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: EXOC3L2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).