Basic Information:

  VIRBase ID:  

HHID00016733

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          EIF2A:  NM_001319045     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	EIF2A
miRBase Accession/Entrez ID	MIMAT0019058	83939
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CDA02//EIF-2A//MST089//MSTP004//MSTP089

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EIF2A	chr3:150288759(+) A-I      intronic chr3:150289107(+) A-I      intronic chr3:150291143(+) A-I      intronic chr3:150295261(+) A-I      intronic chr3:150288794(+) A-I      intronic chr3:150288774(+) A-I      intronic chr3:150279675(+) A-I      intronic chr3:150303175(+) A-I      3'UTR chr3:150279695(+) A-I      intronic chr3:150279701(+) A-I      intronic chr3:150303156(+) A-I      3'UTR chr3:150303148(+) A-I      3'UTR chr3:150279726(+) A-I      intronic chr3:150279729(+) A-I      intronic chr3:150279735(+) A-I      intronic chr3:150279807(+) A-I      intronic chr3:150279936(+) A-I      intronic chr3:150279998(+) A-I      intronic chr3:150280022(+) A-I      intronic chr3:150280047(+) A-I      intronic chr3:150280048(+) A-I      intronic chr3:150280049(+) A-I      intronic chr3:150280088(+) A-I      intronic chr3:150288664(+) A-I      intronic chr3:150288689(+) A-I      intronic chr3:150288693(+) A-I      intronic chr3:150288696(+) A-I      intronic chr3:150288733(+) A-I      intronic chr3:150288762(+) A-I      intronic chr3:150288785(+) A-I      intronic chr3:150288816(+) A-I      intronic chr3:150288818(+) A-I      intronic chr3:150288833(+) A-I      intronic chr3:150288991(+) A-I      intronic chr3:150289007(+) A-I      intronic chr3:150289093(+) A-I      intronic chr3:150289187(+) A-I      intronic chr3:150289188(+) A-I      intronic chr3:150289189(+) A-I      intronic chr3:150293656(+) A-I      intronic chr3:150293661(+) A-I      intronic chr3:150293680(+) A-I      intronic chr3:150293756(+) A-I      intronic chr3:150293760(+) A-I      intronic chr3:150280062(+) A-I      intronic chr3:150269258(+) A-I      intronic chr3:150271407(+) A-I      intronic chr3:150271459(+) A-I      intronic chr3:150271460(+) A-I      intronic chr3:150273443(+) A-I      intronic chr3:150273474(+) A-I      intronic chr3:150279110(+) A-I      intronic chr3:150279155(+) A-I      intronic chr3:150279280(+) A-I      intronic chr3:150279284(+) A-I      intronic chr3:150279633(+) A-I      intronic chr3:150279647(+) A-I      intronic chr3:150303186(+) A-I      3'UTR chr3:150303185(+) A-I      3'UTR chr3:150303179(+) A-I      3'UTR chr3:150303297(+) A-I      3'UTR chr3:150303298(+) A-I      3'UTR chr3:150302865(+) A-I      3'UTR chr3:150302941(+) A-I      3'UTR chr3:150303051(+) A-I      3'UTR chr3:150303052(+) A-I      3'UTR chr3:150303057(+) A-I      3'UTR chr3:150303074(+) A-I      3'UTR chr3:150303172(+) A-I      3'UTR chr3:150303212(+) A-I      3'UTR chr3:150295460(+) A-I      intronic chr3:150279109(+) A-I      intronic chr3:150271387(+) A-I      intronic chr3:150271412(+) A-I      intronic chr3:150288982(+) A-I      intronic chr3:150271335(+) A-I      intronic chr3:150279789(+) A-I      intronic chr3:150289112(+) A-I      intronic chr3:150297235(+) A-I      intronic chr3:150271289(+) A-I      intronic chr3:150271418(+) A-I      intronic chr3:150295482(+) A-I      intronic chr3:150289110(+) A-I      intronic chr3:150290584(+) A-I      intronic chr3:150270958(+) A-I      intronic chr3:150279685(+) A-I      intronic chr3:150273421(+) A-I      intronic chr3:150273420(+) A-I      intronic chr3:150290522(+) A-I      intronic chr3:150279639(+) A-I      intronic chr3:150290432(+) A-I      intronic chr3:150270903(+) A-I      intronic chr3:150277378(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EIF2A	chr3:150286003-150286004(+) m6A 3'UTR//CDS//exon       24284625 chr3:150286026-150286027(+) m6A 3'UTR//CDS       24284625 chr3:150289872-150289873(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:150289910-150289911(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:150289949-150289950(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:150289975-150289976(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:150289982-150289983(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:150289994-150289995(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:150290205-150290206(+) m6A 3'UTR//CDS       24284625//24981863//27773535 chr3:150290249-150290250(+) m6A 3'UTR//CDS       24284625//24981863//27773535 chr3:150290273-150290274(+) m6A 3'UTR//CDS       24284625//24981863//27773535 chr3:150290294-150290295(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535 chr3:150293446-150293447(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr3:150293464-150293465(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr3:150293498-150293499(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr3:150299468-150299469(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr3:150299495-150299496(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr3:150299507-150299508(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr3:150299522-150299523(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr3:150300988-150300989(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr3:150301003-150301004(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr3:150301015-150301016(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr3:150301033-150301034(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr3:150301653-150301654(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr3:150301960-150301961(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	EIF2A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352 Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: EIF2A

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).