Basic Information:

  VIRBase ID:  

HHID00016728

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          FSD1L:  NM_031919     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	FSD1L
miRBase Accession/Entrez ID	MIMAT0019058	83856
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CCDC10//CSDUFD1//FSD1CL//FSD1NL//MIR1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FSD1L	chr9:108213370(+) A-I      intronic chr9:108213500(+) A-I      intronic chr9:108213501(+) A-I      intronic chr9:108213514(+) A-I      intronic chr9:108224493(+) A-I      intronic chr9:108224518(+) A-I      intronic chr9:108224548(+) A-I      intronic chr9:108224667(+) A-I      intronic chr9:108224682(+) A-I      intronic chr9:108230893(+) A-I      intronic chr9:108261085(+) A-I      intronic chr9:108261077(+) A-I      intronic chr9:108224600(+) A-I      intronic chr9:108213358(+) A-I      intronic chr9:108224597(+) A-I      intronic chr9:108224596(+) A-I      intronic chr9:108224577(+) A-I      intronic chr9:108261115(+) A-I      intronic chr9:108225039(+) A-I      intronic chr9:108224702(+) A-I      intronic chr9:108265437(+) A-I      intronic chr9:108224685(+) A-I      intronic chr9:108225272(+) A-I      intronic chr9:108225038(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FSD1L	chr9:108284664(+) A-I intron -    22327324 chr9:108296288(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FSD1L	chr9:108286524-108286525(+) m6A intron       - chr9:108286580-108286581(+) m6A intron       - chr9:108287183-108287184(+) m6A intron       24981863 chr9:108308652-108308653(+) m6A CDS       24981863 chr9:108308695-108308696(+) m6A CDS       24981863 chr9:108308744-108308745(+) m6A CDS       24981863 chr9:108308927-108308928(+) m6A 3'UTR       24981863 chr9:108308972-108308973(+) m6A 3'UTR       24981863 chr9:108309025-108309026(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	FSD1L	Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: FSD1L

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).