Basic Information:

  VIRBase ID:  

HHID00016665

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          CELF6:  NM_052840     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	CELF6
miRBase Accession/Entrez ID	MIMAT0019058	60677
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BRUNOL6

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CELF6	chr15:72592620(-) A-I      intronic chr15:72592619(-) A-I      intronic chr15:72592580(-) A-I      intronic chr15:72592586(-) A-I      intronic chr15:72592578(-) A-I      intronic chr15:72591427(-) A-I      intronic chr15:72593594(-) A-I      intronic chr15:72596487(-) A-I      intronic chr15:72596296(-) A-I      intronic chr15:72603120(-) A-I      intronic chr15:72605720(-) A-I      intronic chr15:72605716(-) A-I      intronic chr15:72594202(-) A-I      intronic chr15:72587948(-) A-I      intronic chr15:72603098(-) A-I      intronic chr15:72601535(-) A-I      intronic chr15:72605708(-) A-I      intronic chr15:72594174(-) A-I      intronic chr15:72601453(-) A-I      intronic chr15:72596363(-) A-I      intronic chr15:72587453(-) A-I      intronic chr15:72593427(-) A-I      intronic chr15:72594296(-) A-I      intronic chr15:72592466(-) A-I      intronic chr15:72591573(-) A-I      intronic chr15:72594297(-) A-I      intronic chr15:72596376(-) A-I      intronic chr15:72604858(-) A-I      intronic chr15:72592572(-) A-I      intronic chr15:72593553(-) A-I      intronic chr15:72587946(-) A-I      intronic chr15:72605712(-) A-I      intronic chr15:72591466(-) A-I      intronic chr15:72592477(-) A-I      intronic chr15:72604802(-) A-I      intronic chr15:72604717(-) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	CELF6	Exosome Blood     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: CELF6

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).