Detail Information

Basic Information:


  VIRBase ID:  

HHID00016656

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:           KLHL14:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4521 KLHL14
miRBase
Accession/Entrez ID
MIMAT0019058 57565
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4521
rs1011991709 chr17:8186962    G/A
rs1011991709 chr17:8186962    G/C
rs1041768648 chr17:8186965    C/T
rs1056190393 chr17:8186959    C/A
rs1231036635 chr17:8186958    T/A
rs1231036635 chr17:8186958    T/G
rs1316923680 chr17:8186964    G/A
rs1316923680 chr17:8186964    G/C
rs1316923680 chr17:8186964    G/T
rs1365122718 chr17:8186957    G/C
rs559116584 chr17:8186963    T/C
rs559116584 chr17:8186963    T/G
rs561824123 chr17:8186969    G/A
rs768576971 chr17:8186966    T/A
rs768576971 chr17:8186966    T/C
rs776348878 chr17:8186967    C/A
rs893173803 chr17:8186960    C/G
rs893173803 chr17:8186960    C/T
rs999343007 chr17:8186968    A/G
rs1310598293 chr17:8186951    A/G
rs928871091 chr17:8186953    G/A
rs928871091 chr17:8186953    G/C
rs937623219 chr17:8186954    G/A
rs953552065 chr17:8186949    C/A
rs953552065 chr17:8186949    C/G
rs953552065 chr17:8186949    C/T
rs962385560 chr17:8186955    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KLHL14
chr18:30305248(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KLHL14
chr18:30254291-30254292(-) m6A 3'UTR       22608085
chr18:30254306-30254307(-) m6A 3'UTR       22608085
chr18:30254357-30254358(-) m6A 3'UTR       24981863//22608085
chr18:30254388-30254389(-) m6A 3'UTR       24981863//22608085
chr18:30254403-30254404(-) m6A 3'UTR       25456834//24981863//22608085
chr18:30254420-30254421(-) m6A 3'UTR       25456834//24981863//22608085
chr18:30254454-30254455(-) m6A 3'UTR       25456834//24981863//22608085
chr18:30254466-30254467(-) m6A 3'UTR       25456834//24981863//22608085
chr18:30254514-30254515(-) m6A 3'UTR       25456834//24981863//22608085
chr18:30254544-30254545(-) m6A 3'UTR       24981863//22608085
chr18:30254597-30254598(-) m6A 3'UTR       24981863//22608085
chr18:30254609-30254610(-) m6A 3'UTR       24981863//22608085
chr18:30254682-30254683(-) m6A CDS       22608085
chr18:30254703-30254704(-) m6A CDS       22608085
chr18:30254708-30254709(-) m6A CDS       22608085
chr18:30254714-30254715(-) m6A CDS       22608085
chr18:30349658-30349659(-) m6A CDS       -
chr18:30349698-30349699(-) m6A CDS       -
chr18:30349800-30349801(-) m6A CDS       27773536
chr18:30349877-30349878(-) m6A CDS       27773536//22608085
chr18:30349953-30349954(-) m6A CDS       27773536
chr18:30350000-30350001(-) m6A CDS       27773536
chr18:30350099-30350100(-) m6A CDS       25456834//27773536
chr18:30350238-30350239(-) m6A CDS       25456834//27773536//22608085
chr18:30350306-30350307(-) m6A CDS       25456834//24981863//27773536//22608085
chr18:30350532-30350533(-) m6A CDS       25456834
chr18:30350537-30350538(-) m6A CDS       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4521
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
KLHL14
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4521
Interactor2: KLHL14

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

Starting a new search, please wait ...