Basic Information:

  VIRBase ID:  

HHID00016654

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          SRGAP1:  NM_001346201     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	SRGAP1
miRBase Accession/Entrez ID	MIMAT0019058	57522
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARHGAP13//NMTC2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SRGAP1	chr12:64405759(+) A-I      intronic chr12:64411367(+) A-I      intronic chr12:64411384(+) A-I      intronic chr12:64411385(+) A-I      intronic chr12:64411390(+) A-I      intronic chr12:64496181(+) A-I      intronic chr12:64411392(+) A-I      intronic chr12:64450212(+) A-I      intronic chr12:64450213(+) A-I      intronic chr12:64450218(+) A-I      intronic chr12:64450219(+) A-I      intronic chr12:64450232(+) A-I      intronic chr12:64450235(+) A-I      intronic chr12:64405619(+) A-I      intronic chr12:64450245(+) A-I      intronic chr12:64450248(+) A-I      intronic chr12:64450253(+) A-I      intronic chr12:64450258(+) A-I      intronic chr12:64499354(+) A-I      intronic chr12:64499369(+) A-I      intronic chr12:64499385(+) A-I      intronic chr12:64499413(+) A-I      intronic chr12:64405624(+) A-I      intronic chr12:64405634(+) A-I      intronic chr12:64405640(+) A-I      intronic chr12:64405641(+) A-I      intronic chr12:64450242(+) A-I      intronic chr12:64405646(+) A-I      intronic chr12:64405662(+) A-I      intronic chr12:64405728(+) A-I      intronic chr12:64405729(+) A-I      intronic chr12:64405730(+) A-I      intronic chr12:64405733(+) A-I      intronic chr12:64405765(+) A-I      intronic chr12:64245109(+) A-I      intronic chr12:64244856(+) A-I      intronic chr12:64244842(+) A-I      intronic chr12:64245989(+) A-I      intronic chr12:64244670(+) A-I      intronic chr12:64241461(+) A-I      intronic chr12:64241458(+) A-I      intronic chr12:64257232(+) A-I      intronic chr12:64257133(+) A-I      intronic chr12:64257114(+) A-I      intronic chr12:64277898(+) A-I      intronic chr12:64307160(+) A-I      intronic chr12:64255856(+) A-I      intronic chr12:64277795(+) A-I      intronic chr12:64285505(+) A-I      intronic chr12:64307172(+) A-I      intronic chr12:64285686(+) A-I      intronic chr12:64255781(+) A-I      intronic chr12:64294086(+) A-I      intronic chr12:64277903(+) A-I      intronic chr12:64255568(+) A-I      intronic chr12:64251361(+) A-I      intronic chr12:64307184(+) A-I      intronic chr12:64307211(+) A-I      intronic chr12:64249425(+) A-I      intronic chr12:64315908(+) A-I      intronic chr12:64267778(+) A-I      intronic chr12:64317683(+) A-I      intronic chr12:64512179(+) A-I      intronic chr12:64509991(+) A-I      intronic chr12:64509983(+) A-I      intronic chr12:64509957(+) A-I      intronic chr12:64246038(+) A-I      intronic chr12:64302745(+) A-I      intronic chr12:64509864(+) A-I      intronic chr12:64509780(+) A-I      intronic chr12:64304913(+) A-I      intronic chr12:64509779(+) A-I      intronic chr12:64317822(+) A-I      intronic chr12:64509777(+) A-I      intronic chr12:64240831(+) A-I      intronic chr12:64285566(+) A-I      intronic chr12:64509773(+) A-I      intronic chr12:64302853(+) A-I      intronic chr12:64267219(+) A-I      intronic chr12:64499817(+) A-I      intronic chr12:64499519(+) A-I      intronic chr12:64499509(+) A-I      intronic chr12:64499425(+) A-I      intronic chr12:64348379(+) A-I      intronic chr12:64397064(+) A-I      intronic chr12:64241028(+) A-I      intronic chr12:64499421(+) A-I      intronic chr12:64499325(+) A-I      intronic chr12:64499314(+) A-I      intronic chr12:64499308(+) A-I      intronic chr12:64348408(+) A-I      intronic chr12:64241035(+) A-I      intronic chr12:64359353(+) A-I      intronic chr12:64359805(+) A-I      intronic chr12:64359822(+) A-I      intronic chr12:64267109(+) A-I      intronic chr12:64241256(+) A-I      intronic chr12:64241260(+) A-I      intronic chr12:64359834(+) A-I      intronic chr12:64397089(+) A-I      intronic chr12:64406533(+) A-I      intronic chr12:64411344(+) A-I      intronic chr12:64411356(+) A-I      intronic chr12:64411892(+) A-I      intronic chr12:64412014(+) A-I      intronic chr12:64412054(+) A-I      intronic chr12:64304918(+) A-I      intronic chr12:64412060(+) A-I      intronic chr12:64304919(+) A-I      intronic chr12:64245997(+) A-I      intronic chr12:64307113(+) A-I      intronic chr12:64412091(+) A-I      intronic chr12:64285611(+) A-I      intronic chr12:64412123(+) A-I      intronic chr12:64412145(+) A-I      intronic chr12:64277901(+) A-I      intronic chr12:64414544(+) A-I      intronic chr12:64414572(+) A-I      intronic chr12:64461090(+) A-I      intronic chr12:64241339(+) A-I      intronic chr12:64285617(+) A-I      intronic chr12:64461908(+) A-I      intronic chr12:64307159(+) A-I      intronic chr12:64461925(+) A-I      intronic chr12:64241415(+) A-I      intronic chr12:64285571(+) A-I      intronic chr12:64496797(+) A-I      intronic chr12:64285636(+) A-I      intronic chr12:64241428(+) A-I      intronic chr12:64496853(+) A-I      intronic chr12:64241432(+) A-I      intronic chr12:64285675(+) A-I      intronic chr12:64496925(+) A-I      intronic chr12:64278053(+) A-I      intronic chr12:64285552(+) A-I      intronic chr12:64294414(+) A-I      intronic chr12:64462631(+) A-I      intronic chr12:64373854(+) A-I      intronic chr12:64285528(+) A-I      intronic chr12:64267701(+) A-I      intronic chr12:64462647(+) A-I      intronic chr12:64249466(+) A-I      intronic chr12:64462639(+) A-I      intronic chr12:64462777(+) A-I      intronic chr12:64317879(+) A-I      intronic chr12:64373978(+) A-I      intronic chr12:64267705(+) A-I      intronic chr12:64496921(+) A-I      intronic chr12:64462632(+) A-I      intronic chr12:64462740(+) A-I      intronic chr12:64462796(+) A-I      intronic chr12:64373910(+) A-I      intronic chr12:64462731(+) A-I      intronic chr12:64244848(+) A-I      intronic chr12:64462686(+) A-I      intronic chr12:64242072(+) A-I      intronic chr12:64462565(+) A-I      intronic chr12:64394337(+) A-I      intronic chr12:64348298(+) A-I      intronic chr12:64462679(+) A-I      intronic chr12:64517020(+) A-I      intronic chr12:64462711(+) A-I      intronic chr12:64462769(+) A-I      intronic chr12:64462651(+) A-I      intronic chr12:64396966(+) A-I      intronic chr12:64462669(+) A-I      intronic chr12:64462640(+) A-I      intronic chr12:64302270(+) A-I      intronic chr12:64374034(+) A-I      intronic chr12:64244663(+) A-I      intronic chr12:64497030(+) A-I      intronic chr12:64462745(+) A-I      intronic chr12:64525909(+) A-I      intronic chr12:64307051(+) A-I      intronic chr12:64462611(+) A-I      intronic chr12:64461961(+) A-I      intronic chr12:64285534(+) A-I      intronic chr12:64249918(+) A-I      intronic chr12:64267741(+) A-I      intronic chr12:64255173(+) A-I      intronic chr12:64538873(+) A-I      3'UTR chr12:64411274(+) A-I      intronic chr12:64253130(+) A-I      intronic chr12:64270885(+) A-I      intronic chr12:64496917(+) A-I      intronic chr12:64270826(+) A-I      intronic chr12:64405715(+) A-I      intronic chr12:64267042(+) A-I      intronic chr12:64285512(+) A-I      intronic chr12:64516492(+) A-I      intronic chr12:64517024(+) A-I      intronic chr12:64307100(+) A-I      intronic chr12:64298449(+) A-I      intronic chr12:64267502(+) A-I      intronic chr12:64277458(+) A-I      intronic chr12:64496886(+) A-I      intronic chr12:64317810(+) A-I      intronic chr12:64316020(+) A-I      intronic chr12:64346661(+) A-I      intronic chr12:64267193(+) A-I      intronic chr12:64307198(+) A-I      intronic chr12:64396916(+) A-I      intronic chr12:64397095(+) A-I      intronic chr12:64280481(+) A-I      intronic chr12:64317768(+) A-I      intronic chr12:64267202(+) A-I      intronic chr12:64380247(+) A-I      intronic chr12:64267685(+) A-I      intronic chr12:64267738(+) A-I      intronic chr12:64255347(+) A-I      intronic chr12:64405724(+) A-I      intronic chr12:64411314(+) A-I      intronic chr12:64268257(+) A-I      intronic chr12:64270802(+) A-I      intronic chr12:64496926(+) A-I      intronic chr12:64267192(+) A-I      intronic chr12:64294192(+) A-I      intronic chr12:64244857(+) A-I      intronic chr12:64241350(+) A-I      intronic chr12:64412092(+) A-I      intronic chr12:64280673(+) A-I      intronic chr12:64496889(+) A-I      intronic chr12:64294184(+) A-I      intronic chr12:64244802(+) A-I      intronic chr12:64245387(+) A-I      intronic chr12:64414476(+) A-I      intronic chr12:64267056(+) A-I      intronic chr12:64380268(+) A-I      intronic chr12:64267657(+) A-I      intronic chr12:64267553(+) A-I      intronic chr12:64255716(+) A-I      intronic chr12:64249365(+) A-I      intronic chr12:64348256(+) A-I      intronic chr12:64406599(+) A-I      intronic chr12:64268159(+) A-I      intronic chr12:64270908(+) A-I      intronic chr12:64285716(+) A-I      intronic chr12:64267303(+) A-I      intronic chr12:64325930(+) A-I      intronic chr12:64317832(+) A-I      intronic chr12:64516500(+) A-I      intronic chr12:64267248(+) A-I      intronic chr12:64499848(+) A-I      intronic chr12:64267732(+) A-I      intronic chr12:64244851(+) A-I      intronic chr12:64411350(+) A-I      intronic chr12:64294415(+) A-I      intronic chr12:64241279(+) A-I      intronic chr12:64397141(+) A-I      intronic chr12:64418153(+) A-I      intronic chr12:64496256(+) A-I      intronic chr12:64255213(+) A-I      intronic chr12:64285698(+) A-I      intronic chr12:64255253(+) A-I      intronic chr12:64411259(+) A-I      intronic chr12:64307056(+) A-I      intronic chr12:64242350(+) A-I      intronic chr12:64285687(+) A-I      intronic chr12:64249364(+) A-I      intronic chr12:64412051(+) A-I      intronic chr12:64346691(+) A-I      intronic chr12:64285691(+) A-I      intronic chr12:64242403(+) A-I      intronic chr12:64412133(+) A-I      intronic chr12:64346648(+) A-I      intronic chr12:64268136(+) A-I      intronic chr12:64377489(+) A-I      5'UTR chr12:64377380(+) A-I      5'UTR chr12:64538871(+) A-I      3'UTR chr12:64377443(+) A-I      5'UTR chr12:64537448(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SRGAP1	chr12:64377380(+) A-I intron -    15258596 chr12:64377443(+) A-I intron -    15258596 chr12:64377489(+) A-I intron -    15258596 chr12:64462565(+) A-I intron -    22028664 chr12:64462611(+) A-I intron -    22028664 chr12:64462631(+) A-I intron -    22028664 chr12:64462632(+) A-I intron -    22028664 chr12:64462639(+) A-I intron -    22028664 chr12:64462640(+) A-I intron -    22028664 chr12:64462647(+) A-I intron -    22028664 chr12:64462651(+) A-I intron -    22028664 chr12:64462654(+) A-I intron -    22028664 chr12:64462669(+) A-I intron -    22028664 chr12:64462679(+) A-I intron -    22028664 chr12:64462686(+) A-I intron -    22028664 chr12:64462711(+) A-I intron -    22028664 chr12:64462731(+) A-I intron -    22028664 chr12:64462740(+) A-I intron -    22028664 chr12:64462745(+) A-I intron -    22028664 chr12:64462769(+) A-I intron -    22028664 chr12:64462777(+) A-I intron -    22028664 chr12:64462796(+) A-I intron -    22028664 chr12:64254629(+) A-I intron -    21960545 chr12:64399185(+) A-I intron -    21960545 chr12:64496273(+) A-I intron -    21960545 chr12:64496285(+) A-I intron -    21960545 chr12:64245387(+) A-G intron -    22484847 chr12:64249364(+) A-G intron -    22484847 chr12:64249365(+) A-G intron -    22484847 chr12:64255173(+) A-G intron -    22484847 chr12:64255347(+) A-G intron -    22484847 chr12:64267732(+) A-G intron -    22484847 chr12:64267741(+) A-G intron -    22484847 chr12:64294184(+) A-G intron -    22484847 chr12:64294192(+) A-G intron -    22484847 chr12:64294414(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SRGAP1	chr12:64377748-64377749(+) m6A 5'UTR//CDS//exon       24981863 chr12:64377890-64377891(+) m6A CDS//exon       24981863 chr12:64383694-64383695(+) m6A CDS//exon       24981863 chr12:64436640-64436641(+) m6A CDS//exon       24981863 chr12:64436703-64436704(+) m6A CDS//exon       24981863 chr12:64437228-64437229(+) m6A CDS//exon       24981863 chr12:64521795-64521796(+) m6A CDS//exon       24284625 chr12:64521960-64521961(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr12:64521968-64521969(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr12:64536093-64536094(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr12:64536109-64536110(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr12:64536118-64536119(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr12:64536127-64536128(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr12:64536186-64536187(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr12:64536367-64536368(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr12:64536386-64536387(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr12:64536403-64536404(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr12:64536432-64536433(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr12:64536454-64536455(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr12:64536600-64536601(+) m6A 3'UTR       24981863 chr12:64536653-64536654(+) m6A 3'UTR       24981863 chr12:64536671-64536672(+) m6A 3'UTR       24981863//22608085 chr12:64536680-64536681(+) m6A 3'UTR       24981863//22608085 chr12:64536688-64536689(+) m6A 3'UTR       24981863//22608085 chr12:64536813-64536814(+) m6A 3'UTR       24284625//24981863 chr12:64536952-64536953(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr12:64536987-64536988(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr12:64537063-64537064(+) m6A 3'UTR       24284625//24981863//22575960//22608085 chr12:64537083-64537084(+) m6A 3'UTR       24284625//24981863//22575960//22608085 chr12:64537104-64537105(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr12:64537129-64537130(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr12:64537243-64537244(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr12:64537268-64537269(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr12:64539578-64539579(+) m6A 3'UTR       24981863 chr12:64541277-64541278(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	SRGAP1	Exosome Blood     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: SRGAP1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).