Basic Information:

  VIRBase ID:  

HHID00016630

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          WDR12:  NM_001371664     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	WDR12
miRBase Accession/Entrez ID	MIMAT0019058	55759
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	YTM1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WDR12	chr2:203749812(-) A-I      intronic chr2:203767693(-) A-I      intronic chr2:203763078(-) A-I      intronic chr2:203755936(-) A-I      intronic chr2:203745214(-) A-I      3'UTR chr2:203763077(-) A-I      intronic chr2:203763054(-) A-I      intronic chr2:203763045(-) A-I      intronic chr2:203763043(-) A-I      intronic chr2:203755962(-) A-I      intronic chr2:203754946(-) A-I      intronic chr2:203755947(-) A-I      intronic chr2:203752034(-) A-I      intronic chr2:203746253(-) A-I      intronic chr2:203746307(-) A-I      intronic chr2:203746389(-) A-I      intronic chr2:203750578(-) A-I      intronic chr2:203750579(-) A-I      intronic chr2:203750626(-) A-I      intronic chr2:203761628(-) A-I      intronic chr2:203761627(-) A-I      intronic chr2:203833856(-) A-I      intronic chr2:203837183(-) A-I      intronic chr2:203839417(-) A-I      intronic chr2:203839418(-) A-I      intronic chr2:203761544(-) A-I      intronic chr2:203794504(-) A-I      intronic chr2:203750631(-) A-I      intronic chr2:203750668(-) A-I      intronic chr2:203750680(-) A-I      intronic chr2:203751814(-) A-I      intronic chr2:203751843(-) A-I      intronic chr2:203751974(-) A-I      intronic chr2:203751989(-) A-I      intronic chr2:203754884(-) A-I      intronic chr2:203755234(-) A-I      intronic chr2:203755236(-) A-I      intronic chr2:203755248(-) A-I      intronic chr2:203755249(-) A-I      intronic chr2:203755267(-) A-I      intronic chr2:203755311(-) A-I      intronic chr2:203755431(-) A-I      intronic chr2:203755987(-) A-I      intronic chr2:203756066(-) A-I      intronic chr2:203775097(-) A-I      intronic chr2:203774702(-) A-I      intronic chr2:203771423(-) A-I      intronic chr2:203771395(-) A-I      intronic chr2:203761211(-) A-I      intronic chr2:203770147(-) A-I      intronic chr2:203770099(-) A-I      intronic chr2:203770094(-) A-I      intronic chr2:203764638(-) A-I      intronic chr2:203763014(-) A-I      intronic chr2:203762989(-) A-I      intronic chr2:203756115(-) A-I      intronic chr2:203756123(-) A-I      intronic chr2:203857558(-) A-I      intronic chr2:203756124(-) A-I      intronic chr2:203761493(-) A-I      intronic chr2:203761530(-) A-I      intronic chr2:203857559(-) A-I      intronic chr2:203861789(-) A-I      intronic chr2:203861797(-) A-I      intronic chr2:203861810(-) A-I      intronic chr2:203746247(-) A-I      intronic chr2:203745059(-) A-I      3'UTR chr2:203745079(-) A-I      3'UTR chr2:203745114(-) A-I      3'UTR chr2:203745163(-) A-I      3'UTR chr2:203753559(-) A-I      intronic chr2:203750747(-) A-I      intronic chr2:203746895(-) A-I      intronic chr2:203755607(-) A-I      intronic chr2:203751008(-) A-I      intronic chr2:203746824(-) A-I      intronic chr2:203763973(-) A-I      intronic chr2:203755709(-) A-I      intronic chr2:203755980(-) A-I      intronic chr2:203746822(-) A-I      intronic chr2:203763057(-) A-I      intronic chr2:203751167(-) A-I      intronic chr2:203771439(-) A-I      intronic chr2:203750517(-) A-I      intronic chr2:203746924(-) A-I      intronic chr2:203756145(-) A-I      intronic chr2:203753519(-) A-I      intronic chr2:203753564(-) A-I      intronic chr2:203753533(-) A-I      intronic chr2:203751175(-) A-I      intronic chr2:203750603(-) A-I      intronic chr2:203751911(-) A-I      intronic chr2:203871922(-) A-I      intronic chr2:203751923(-) A-I      intronic chr2:203753632(-) A-I      intronic chr2:203753538(-) A-I      intronic chr2:203751778(-) A-I      intronic chr2:203861445(-) A-I      intronic chr2:203746773(-) A-I      intronic chr2:203745189(-) A-I      3'UTR chr2:203745269(-) A-I      3'UTR chr2:203745105(-) A-I      3'UTR chr2:203745123(-) A-I      3'UTR chr2:203745036(-) A-I      3'UTR chr2:203745088(-) A-I      3'UTR chr2:203745147(-) A-I      3'UTR chr2:203745170(-) A-I      3'UTR chr2:203745159(-) A-I      3'UTR chr2:203745171(-) A-I      3'UTR chr2:203745195(-) A-I      3'UTR chr2:203745122(-) A-I      3'UTR chr2:203745219(-) A-I      3'UTR chr2:203745041(-) A-I      3'UTR chr2:203745149(-) A-I      3'UTR chr2:203745224(-) A-I      3'UTR chr2:203745208(-) A-I      3'UTR chr2:203868149(-) A-I      intronic chr2:203753603(-) A-I      intronic chr2:203750617(-) A-I      intronic chr2:203754816(-) A-I      intronic chr2:203871916(-) A-I      intronic chr2:203755665(-) A-I      intronic chr2:203763124(-) A-I      intronic chr2:203863674(-) A-I      intronic chr2:203746269(-) A-I      intronic chr2:203754875(-) A-I      intronic chr2:203751819(-) A-I      intronic chr2:203854119(-) A-I      intronic chr2:203750935(-) A-I      intronic chr2:203753628(-) A-I      intronic chr2:203750698(-) A-I      intronic chr2:203763106(-) A-I      intronic chr2:203750526(-) A-I      intronic chr2:203753508(-) A-I      intronic chr2:203746567(-) A-I      intronic chr2:203753688(-) A-I      intronic chr2:203753587(-) A-I      intronic chr2:203751125(-) A-I      intronic chr2:203754811(-) A-I      intronic chr2:203756034(-) A-I      intronic chr2:203750923(-) A-I      intronic chr2:203767556(-) A-I      intronic chr2:203751118(-) A-I      intronic chr2:203746349(-) A-I      intronic chr2:203750600(-) A-I      intronic chr2:203767574(-) A-I      intronic chr2:203753600(-) A-I      intronic chr2:203763588(-) A-I      intronic chr2:203751119(-) A-I      intronic chr2:203752019(-) A-I      intronic chr2:203750632(-) A-I      intronic chr2:203759050(-) A-I      intronic chr2:203756076(-) A-I      intronic chr2:203746818(-) A-I      intronic chr2:203752355(-) A-I      intronic chr2:203753557(-) A-I      intronic chr2:203853454(-) A-I      intronic chr2:203750697(-) A-I      intronic chr2:203753528(-) A-I      intronic chr2:203754835(-) A-I      intronic chr2:203746835(-) A-I      intronic chr2:203753550(-) A-I      intronic chr2:203755673(-) A-I      intronic chr2:203756154(-) A-I      intronic chr2:203751853(-) A-I      intronic chr2:203751943(-) A-I      intronic chr2:203750723(-) A-I      intronic chr2:203755710(-) A-I      intronic chr2:203755303(-) A-I      intronic chr2:203751014(-) A-I      intronic chr2:203764040(-) A-I      intronic chr2:203763894(-) A-I      intronic chr2:203751368(-) A-I      intronic chr2:203750620(-) A-I      intronic chr2:203753651(-) A-I      intronic chr2:203746382(-) A-I      intronic chr2:203753689(-) A-I      intronic chr2:203746392(-) A-I      intronic chr2:203756148(-) A-I      intronic chr2:203750728(-) A-I      intronic chr2:203753496(-) A-I      intronic chr2:203751129(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	WDR12	chr2:203746349(-) A-G intron -    22484847 chr2:203746895(-) A-G intron -    22484847 chr2:203750603(-) A-G intron -    22484847 chr2:203750697(-) A-G intron -    22484847 chr2:203750698(-) A-G intron -    22484847 chr2:203750929(-) A-G intron -    22484847 chr2:203750936(-) A-G intron -    22484847 chr2:203751008(-) A-G intron -    22484847 chr2:203751118(-) A-G intron -    22484847 chr2:203751119(-) A-G intron -    22484847 chr2:203751129(-) A-G intron -    22484847 chr2:203751368(-) A-G intron -    22484847 chr2:203751490(-) G-T intron -    22484847 chr2:203751815(-) A-G intron -    22484847 chr2:203751820(-) A-G intron -    22484847 chr2:203751829(-) A-G intron -    22484847 chr2:203751853(-) A-G intron -    22484847 chr2:203751884(-) A-G intron -    22484847 chr2:203753538(-) A-G intron -    22484847 chr2:203753550(-) A-G intron -    22484847 chr2:203753557(-) A-G intron -    22484847 chr2:203753587(-) A-G intron -    22484847 chr2:203753628(-) A-G intron -    22484847 chr2:203754816(-) A-G intron -    22484847 chr2:203754835(-) A-G intron -    22484847 chr2:203755303(-) A-G intron -    22484847 chr2:203755665(-) A-G intron -    22484847 chr2:203755709(-) A-G intron -    22484847 chr2:203755710(-) A-G intron -    22484847 chr2:203755718(-) A-T intron -    22484847 chr2:203755719(-) A-T intron -    22484847 chr2:203755963(-) A-G intron -    22484847 chr2:203755980(-) A-G intron -    22484847 chr2:203756076(-) A-G intron -    22484847 chr2:203756145(-) A-G intron -    22484847 chr2:203756148(-) A-G intron -    22484847 chr2:203763972(-) A-G intron -    22484847 chr2:203771439(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WDR12	chr2:203739526-203739527(-) m6A 3'UTR       27773535 chr2:203739676-203739677(-) m6A 3'UTR       27773535 chr2:203739720-203739721(-) m6A 3'UTR       27773535 chr2:203739729-203739730(-) m6A 3'UTR       27773535 chr2:203739778-203739779(-) m6A 3'UTR       27773535 chr2:203739851-203739852(-) m6A 3'UTR       27773535 chr2:203739863-203739864(-) m6A 3'UTR       27773535 chr2:203740585-203740586(-) m6A 3'UTR       27773535 chr2:203740669-203740670(-) m6A 3'UTR       27773535 chr2:203742641-203742642(-) m6A 3'UTR       27773535 chr2:203742693-203742694(-) m6A 3'UTR       27773535 chr2:203742727-203742728(-) m6A 3'UTR       27773535 chr2:203742772-203742773(-) m6A 3'UTR       27773535 chr2:203744780-203744781(-) m6A 3'UTR       27773535 chr2:203757348-203757349(-) m6A CDS//exon       24981863 chr2:203757357-203757358(-) m6A CDS//exon       24981863 chr2:203757362-203757363(-) m6A CDS//exon       24981863 chr2:203757369-203757370(-) m6A CDS//exon       24981863 chr2:203762062-203762063(-) m6A CDS//exon       - chr2:203762112-203762113(-) m6A CDS//exon       - chr2:203765757-203765758(-) m6A CDS//exon       - chr2:203765778-203765779(-) m6A CDS//exon       - chr2:203776183-203776184(-) m6A CDS//intron       27773535 chr2:203776592-203776593(-) m6A 5'UTR//intron       24981863//22608085 chr2:203776608-203776609(-) m6A 5'UTR//intron       24981863//27773535//22608085 chr2:203776636-203776637(-) m6A 5'UTR//intron       24981863//27773535//22608085 chr2:203776684-203776685(-) m6A 5'UTR//intron       24981863//27773535//22608085 chr2:203776797-203776798(-) m6A 5'UTR//intron       24284625//24981863//27773535//22608085 chr2:203776845-203776846(-) m6A 5'UTR//intron       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	WDR12	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: WDR12

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).