Detail Information

Basic Information:


  VIRBase ID:  

HHID00016623

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:           LRRC40:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4521 LRRC40
miRBase
Accession/Entrez ID		 MIMAT0019058 55631
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - dJ677H15.1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4521
rs1011991709 chr17:8186962    G/A
rs1011991709 chr17:8186962    G/C
rs1041768648 chr17:8186965    C/T
rs1056190393 chr17:8186959    C/A
rs1231036635 chr17:8186958    T/A
rs1231036635 chr17:8186958    T/G
rs1316923680 chr17:8186964    G/A
rs1316923680 chr17:8186964    G/C
rs1316923680 chr17:8186964    G/T
rs1365122718 chr17:8186957    G/C
rs559116584 chr17:8186963    T/C
rs559116584 chr17:8186963    T/G
rs561824123 chr17:8186969    G/A
rs768576971 chr17:8186966    T/A
rs768576971 chr17:8186966    T/C
rs776348878 chr17:8186967    C/A
rs893173803 chr17:8186960    C/G
rs893173803 chr17:8186960    C/T
rs999343007 chr17:8186968    A/G
rs1310598293 chr17:8186951    A/G
rs928871091 chr17:8186953    G/A
rs928871091 chr17:8186953    G/C
rs937623219 chr17:8186954    G/A
rs953552065 chr17:8186949    C/A
rs953552065 chr17:8186949    C/G
rs953552065 chr17:8186949    C/T
rs962385560 chr17:8186955    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR LRRC40
chr1:70626806(-) A-I      intronic
chr1:70627148(-) A-I      intronic
chr1:70629908(-) A-I      intronic
chr1:70629964(-) A-I      intronic
chr1:70629967(-) A-I      intronic
chr1:70632126(-) A-I      intronic
chr1:70632186(-) A-I      intronic
chr1:70662067(-) A-I      intronic
chr1:70632228(-) A-I      intronic
chr1:70632231(-) A-I      intronic
chr1:70662084(-) A-I      intronic
chr1:70662085(-) A-I      intronic
chr1:70663138(-) A-I      intronic
chr1:70663518(-) A-I      intronic
chr1:70663519(-) A-I      intronic
chr1:70663583(-) A-I      intronic
chr1:70663597(-) A-I      intronic
chr1:70663641(-) A-I      intronic
chr1:70632257(-) A-I      intronic
chr1:70632998(-) A-I      intronic
chr1:70633051(-) A-I      intronic
chr1:70633118(-) A-I      intronic
chr1:70633475(-) A-I      intronic
chr1:70633486(-) A-I      intronic
chr1:70633501(-) A-I      intronic
chr1:70633525(-) A-I      intronic
chr1:70633573(-) A-I      intronic
chr1:70649374(-) A-I      intronic
chr1:70656161(-) A-I      intronic
chr1:70662014(-) A-I      intronic
chr1:70662030(-) A-I      intronic
chr1:70611935(-) A-I      intronic
chr1:70618823(-) A-I      intronic
chr1:70666739(-) A-I      intronic
chr1:70668609(-) A-I      intronic
chr1:70668775(-) A-I      intronic
chr1:70669129(-) A-I      intronic
chr1:70632304(-) A-I      intronic
chr1:70629043(-) A-I      intronic
chr1:70668864(-) A-I      intronic
chr1:70633060(-) A-I      intronic
chr1:70632986(-) A-I      intronic
chr1:70632309(-) A-I      intronic
chr1:70632197(-) A-I      intronic
chr1:70663724(-) A-I      intronic
chr1:70668712(-) A-I      intronic
chr1:70626896(-) A-I      intronic
chr1:70633026(-) A-I      intronic
chr1:70628950(-) A-I      intronic
chr1:70632254(-) A-I      intronic
chr1:70627172(-) A-I      intronic
chr1:70628999(-) A-I      intronic
chr1:70629005(-) A-I      intronic
chr1:70628973(-) A-I      intronic
chr1:70662150(-) A-I      intronic
chr1:70633196(-) A-I      intronic
chr1:70662202(-) A-I      intronic
chr1:70663711(-) A-I      intronic
chr1:70633499(-) A-I      intronic
chr1:70668706(-) A-I      intronic
chr1:70627123(-) A-I      intronic
chr1:70649359(-) A-I      intronic
chr1:70663663(-) A-I      intronic
chr1:70663709(-) A-I      intronic
chr1:70630034(-) A-I      intronic
chr1:70665964(-) A-I      intronic
chr1:70633365(-) A-I      intronic
chr1:70628882(-) A-I      intronic
chr1:70633497(-) A-I      intronic
chr1:70633426(-) A-I      intronic
chr1:70632232(-) A-I      intronic
chr1:70663645(-) A-I      intronic
chr1:70633571(-) A-I      intronic
chr1:70627194(-) A-I      intronic
chr1:70629042(-) A-I      intronic
chr1:70628887(-) A-I      intronic
chr1:70649469(-) A-I      intronic
chr1:70632258(-) A-I      intronic
chr1:70633124(-) A-I      intronic
chr1:70633570(-) A-I      intronic
chr1:70649356(-) A-I      intronic
chr1:70633397(-) A-I      intronic
chr1:70649396(-) A-I      intronic
chr1:70627178(-) A-I      intronic
chr1:70630026(-) A-I      intronic
chr1:70649492(-) A-I      intronic
chr1:70663664(-) A-I      intronic
chr1:70656249(-) A-I      intronic
chr1:70633191(-) A-I      intronic
chr1:70668733(-) A-I      intronic
chr1:70633436(-) A-I      intronic
chr1:70633086(-) A-I      intronic
chr1:70632124(-) A-I      intronic
chr1:70649849(-) A-I      intronic
chr1:70627185(-) A-I      intronic
chr1:70632099(-) A-I      intronic
chr1:70628965(-) A-I      intronic
chr1:70627151(-) A-I      intronic
chr1:70632224(-) A-I      intronic
chr1:70626828(-) A-I      intronic
chr1:70662151(-) A-I      intronic
chr1:70633394(-) A-I      intronic
chr1:70649850(-) A-I      intronic
chr1:70649523(-) A-I      intronic
chr1:70611890(-) A-I      intronic
chr1:70626836(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED LRRC40
chr1:70624905(-) T-C intron -    22484847
chr1:70627151(-) A-G intron -    22484847
chr1:70628882(-) A-G intron -    22484847
chr1:70628887(-) A-G intron -    22484847
chr1:70630026(-) A-G intron -    22484847
chr1:70630034(-) A-G intron -    22484847
chr1:70632124(-) A-G intron -    22484847
chr1:70632197(-) A-G intron -    22484847
chr1:70632224(-) A-G intron -    22484847
chr1:70632232(-) A-G intron -    22484847
chr1:70632254(-) A-G intron -    22484847
chr1:70632258(-) A-G intron -    22484847
chr1:70632986(-) A-G intron -    22484847
chr1:70633026(-) A-G intron -    22484847
chr1:70633060(-) A-G intron -    22484847
chr1:70633086(-) A-G intron -    22484847
chr1:70633124(-) A-G intron -    22484847
chr1:70633191(-) A-G intron -    22484847
chr1:70633397(-) A-G intron -    22484847
chr1:70633436(-) A-G intron -    22484847
chr1:70633497(-) A-G intron -    22484847
chr1:70633499(-) A-G intron -    22484847
chr1:70633570(-) A-G intron -    22484847
chr1:70633571(-) A-G intron -    22484847
chr1:70649396(-) A-G intron -    22484847
chr1:70649523(-) A-G intron -    22484847
chr1:70649849(-) A-G intron -    22484847
chr1:70649850(-) A-G intron -    22484847
chr1:70662150(-) A-G intron -    22484847
chr1:70662151(-) A-G intron -    22484847
chr1:70662202(-) A-G intron -    22484847
chr1:70663645(-) A-G intron -    22484847
chr1:70663711(-) A-G intron -    22484847
chr1:70665964(-) A-G intron -    22484847
chr1:70668706(-) A-G intron -    22484847
chr1:70668712(-) A-G intron -    22484847
chr1:70668864(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LRRC40
chr1:70610893-70610894(-) m6A 3'UTR       27773535
chr1:70610915-70610916(-) m6A 3'UTR       27773535
chr1:70610954-70610955(-) m6A 3'UTR       27773535
chr1:70621472-70621473(-) m6A CDS       27773535
chr1:70625018-70625019(-) m6A CDS       27773535
chr1:70625085-70625086(-) m6A CDS       27773535
chr1:70625113-70625114(-) m6A CDS       24981863//27773535
chr1:70671083-70671084(-) m6A CDS       27773535
chr1:70671098-70671099(-) m6A CDS       27773535
chr1:70671122-70671123(-) Cm CDS       -
chr1:70671158-70671159(-) m6A CDS       24209618//24981863//27773535//27371828//22608085
chr1:70671224-70671225(-) m6A 5'UTR       24209618//25456834//24981863//27371828//22608085
chr1:70671231-70671232(-) m6A 5'UTR       24209618//25456834//24981863//27371828//22608085
chr1:70671238-70671239(-) m6A 5'UTR       24209618//25456834//24981863//27371828//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4521
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
LRRC40
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)     -
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4521
Interactor2: LRRC40

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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