Basic Information:

  VIRBase ID:  

HHID00016618

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          PGM2:  NM_018290     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	PGM2
miRBase Accession/Entrez ID	MIMAT0019058	55276
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MSTP006

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PGM2	chr4:37851594(+) A-I      intronic chr4:37851575(+) A-I      intronic chr4:37851583(+) A-I      intronic chr4:37851643(+) A-I      intronic chr4:37856072(+) A-I      intronic chr4:37856172(+) A-I      intronic chr4:37856181(+) A-I      intronic chr4:37850514(+) A-I      intronic chr4:37850597(+) A-I      intronic chr4:37850612(+) A-I      intronic chr4:37839632(+) A-I      intronic chr4:37851538(+) A-I      intronic chr4:37851548(+) A-I      intronic chr4:37856206(+) A-I      intronic chr4:37851494(+) A-I      intronic chr4:37856152(+) A-I      intronic chr4:37852197(+) A-I      intronic chr4:37856155(+) A-I      intronic chr4:37850515(+) A-I      intronic chr4:37850544(+) A-I      intronic chr4:37851592(+) A-I      intronic chr4:37839669(+) A-I      intronic chr4:37851469(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PGM2	chr4:37864482(+) G-A intron -    21725310 chr4:37850515(+) A-G intron -    22484847 chr4:37851245(+) G-T intron -    22484847 chr4:37852197(+) A-G intron -    22484847 chr4:37856036(+) A-G intron -    22484847 chr4:37856152(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PGM2	chr4:37828400-37828401(+) m6A CDS       24981863//22608085 chr4:37828408-37828409(+) m6A CDS       24981863//22608085 chr4:37828430-37828431(+) m6A CDS       24981863//22608085 chr4:37831641-37831642(+) m6A CDS       - chr4:37846109-37846110(+) Am 3'UTR//CDS//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	PGM2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus Colon cancer cells     24393600 Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: PGM2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).