Detail Information

Basic Information:


  VIRBase ID:  

HHID00016565

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:           RNF141:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4521 RNF141
miRBase
Accession/Entrez ID		 MIMAT0019058 50862
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - RFP141//ZFP26//ZNF230

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4521
rs1011991709 chr17:8186962    G/A
rs1011991709 chr17:8186962    G/C
rs1041768648 chr17:8186965    C/T
rs1056190393 chr17:8186959    C/A
rs1231036635 chr17:8186958    T/A
rs1231036635 chr17:8186958    T/G
rs1316923680 chr17:8186964    G/A
rs1316923680 chr17:8186964    G/C
rs1316923680 chr17:8186964    G/T
rs1365122718 chr17:8186957    G/C
rs559116584 chr17:8186963    T/C
rs559116584 chr17:8186963    T/G
rs561824123 chr17:8186969    G/A
rs768576971 chr17:8186966    T/A
rs768576971 chr17:8186966    T/C
rs776348878 chr17:8186967    C/A
rs893173803 chr17:8186960    C/G
rs893173803 chr17:8186960    C/T
rs999343007 chr17:8186968    A/G
rs1310598293 chr17:8186951    A/G
rs928871091 chr17:8186953    G/A
rs928871091 chr17:8186953    G/C
rs937623219 chr17:8186954    G/A
rs953552065 chr17:8186949    C/A
rs953552065 chr17:8186949    C/G
rs953552065 chr17:8186949    C/T
rs962385560 chr17:8186955    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RNF141
chr11:10534238(-) A-I      3'UTR
chr11:10535402(-) A-I      3'UTR
chr11:10535496(-) A-I      3'UTR
chr11:10535502(-) A-I      3'UTR
chr11:10534242(-) A-I      3'UTR
chr11:10535362(-) A-I      3'UTR
chr11:10534231(-) A-I      3'UTR
chr11:10535380(-) A-I      3'UTR
chr11:10535372(-) A-I      3'UTR
chr11:10535356(-) A-I      3'UTR
chr11:10535339(-) A-I      3'UTR
chr11:10535391(-) A-I      3'UTR
chr11:10535495(-) A-I      3'UTR
chr11:10535392(-) A-I      3'UTR
chr11:10535455(-) A-I      3'UTR
chr11:10535418(-) A-I      3'UTR
chr11:10535405(-) A-I      3'UTR
chr11:10535393(-) A-I      3'UTR
chr11:10535394(-) A-I      3'UTR
chr11:10534263(-) A-I      3'UTR
chr11:10534281(-) A-I      3'UTR
chr11:10534282(-) A-I      3'UTR
chr11:10534290(-) A-I      3'UTR
chr11:10535397(-) A-I      3'UTR
chr11:10535388(-) A-I      3'UTR
chr11:10535259(-) A-I      3'UTR
chr11:10535361(-) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RNF141
chr11:10535102-10535103(-) m6A 3'UTR//exon       27773535
chr11:10535234-10535235(-) m6A 3'UTR//exon       24981863
chr11:10535253-10535254(-) m6A 3'UTR//exon       24981863
chr11:10535263-10535264(-) m6A 3'UTR//exon       24981863
chr11:10555699-10555700(-) m6A CDS       27371828
chr11:10555717-10555718(-) m6A 5'UTR       27371828
chr11:10555749-10555750(-) m6A 5'UTR       27371828
chr11:10562323-10562324(-) m6A 5'UTR//intron       24981863//27371828
chr11:10562401-10562402(-) m6A 5'UTR//intron       24981863//27371828
chr11:10562674-10562675(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4521
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
RNF141
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4521
Interactor2: RNF141

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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