Basic Information:

  VIRBase ID:  

HHID00016563

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          KCNIP2:  NM_173197     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	KCNIP2
miRBase Accession/Entrez ID	MIMAT0019058	30819
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	KCHIP2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KCNIP2	chr10:103596188(-) A-I      intronic chr10:103596165(-) A-I      intronic chr10:103596162(-) A-I      intronic chr10:103596189(-) A-I      intronic chr10:103596197(-) A-I      intronic chr10:103596606(-) A-I      intronic chr10:103596618(-) A-I      intronic chr10:103596168(-) A-I      intronic chr10:103596596(-) A-I      intronic chr10:103596206(-) A-I      intronic chr10:103596832(-) A-I      intronic chr10:103596067(-) A-I      intronic chr10:103596220(-) A-I      intronic chr10:103596173(-) A-I      intronic chr10:103596570(-) A-I      intronic chr10:103596854(-) A-I      intronic chr10:103596070(-) A-I      intronic chr10:103596580(-) A-I      intronic chr10:103597304(-) A-I      intronic chr10:103597298(-) A-I      intronic chr10:103596144(-) A-I      intronic chr10:103596778(-) A-I      intronic chr10:103597297(-) A-I      intronic chr10:103597278(-) A-I      intronic chr10:103597238(-) A-I      intronic chr10:103596033(-) A-I      intronic chr10:103596526(-) A-I      intronic chr10:103596175(-) A-I      intronic chr10:103596136(-) A-I      intronic chr10:103596680(-) A-I      intronic chr10:103596135(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KCNIP2	chr10:103596067(-) A-I intron -    15342557 chr10:103596135(-) A-I intron -    15342557 chr10:103596136(-) A-I intron -    15342557 chr10:103596144(-) A-I intron -    15342557 chr10:103596175(-) A-I intron -    15342557 chr10:103596526(-) A-I intron -    15342557 chr10:103596596(-) A-I intron -    15342557

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KCNIP2	chr10:103585957-103585958(-) m6A 3'UTR//exon       - chr10:103585965-103585966(-) m6A 3'UTR//exon       - chr10:103588077-103588078(-) m6A exon//intron       - chr10:103588421-103588422(-) m6A CDS//exon       22608085 chr10:103603438-103603439(-) m6A 5'UTR//exon       - chr10:103603455-103603456(-) m6A 5'UTR//exon       - chr10:103603474-103603475(-) m6A 5'UTR//exon       - chr10:103603481-103603482(-) m6A 5'UTR//exon       - chr10:103603493-103603494(-) m6A 5'UTR//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	KCNIP2	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: KCNIP2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).