Basic Information:

  VIRBase ID:  

HHID00016511

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          FBXO28:  NR_049764     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	FBXO28
miRBase Accession/Entrez ID	MIMAT0019058	23219
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CENP-30//Fbx28

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FBXO28	chr1:224324663(+) A-I      intronic chr1:224329652(+) A-I      intronic chr1:224329646(+) A-I      intronic chr1:224324715(+) A-I      intronic chr1:224324654(+) A-I      intronic chr1:224324651(+) A-I      intronic chr1:224324644(+) A-I      intronic chr1:224327536(+) A-I      intronic chr1:224326470(+) A-I      intronic chr1:224326520(+) A-I      intronic chr1:224326583(+) A-I      intronic chr1:224326667(+) A-I      intronic chr1:224325074(+) A-I      intronic chr1:224326668(+) A-I      intronic chr1:224326670(+) A-I      intronic chr1:224325016(+) A-I      intronic chr1:224325002(+) A-I      intronic chr1:224326684(+) A-I      intronic chr1:224342972(+) A-I      intronic chr1:224326696(+) A-I      intronic chr1:224326747(+) A-I      intronic chr1:224326759(+) A-I      intronic chr1:224326761(+) A-I      intronic chr1:224324728(+) A-I      intronic chr1:224327257(+) A-I      intronic chr1:224327322(+) A-I      intronic chr1:224306975(+) A-I      intronic chr1:224329660(+) A-I      intronic chr1:224327611(+) A-I      intronic chr1:224327666(+) A-I      intronic chr1:224327742(+) A-I      intronic chr1:224324716(+) A-I      intronic chr1:224328456(+) A-I      intronic chr1:224328471(+) A-I      intronic chr1:224342971(+) A-I      intronic chr1:224328494(+) A-I      intronic chr1:224337083(+) A-I      intronic chr1:224328541(+) A-I      intronic chr1:224328804(+) A-I      intronic chr1:224304987(+) A-I      intronic chr1:224327229(+) A-I      intronic chr1:224328805(+) A-I      intronic chr1:224304719(+) A-I      intronic chr1:224329630(+) A-I      intronic chr1:224329658(+) A-I      intronic chr1:224324674(+) A-I      intronic chr1:224324611(+) A-I      intronic chr1:224324588(+) A-I      intronic chr1:224329677(+) A-I      intronic chr1:224329695(+) A-I      intronic chr1:224304955(+) A-I      intronic chr1:224329704(+) A-I      intronic chr1:224342968(+) A-I      intronic chr1:224342967(+) A-I      intronic chr1:224329717(+) A-I      intronic chr1:224329798(+) A-I      intronic chr1:224329799(+) A-I      intronic chr1:224329911(+) A-I      intronic chr1:224329999(+) A-I      intronic chr1:224330004(+) A-I      intronic chr1:224330036(+) A-I      intronic chr1:224330073(+) A-I      intronic chr1:224304773(+) A-I      intronic chr1:224330465(+) A-I      intronic chr1:224342595(+) A-I      intronic chr1:224330573(+) A-I      intronic chr1:224330593(+) A-I      intronic chr1:224331638(+) A-I      intronic chr1:224331722(+) A-I      intronic chr1:224331742(+) A-I      intronic chr1:224332184(+) A-I      intronic chr1:224332200(+) A-I      intronic chr1:224342118(+) A-I      intronic chr1:224332375(+) A-I      intronic chr1:224332400(+) A-I      intronic chr1:224309667(+) A-I      intronic chr1:224337180(+) A-I      intronic chr1:224332449(+) A-I      intronic chr1:224333454(+) A-I      intronic chr1:224324283(+) A-I      intronic chr1:224323719(+) A-I      intronic chr1:224323718(+) A-I      intronic chr1:224323661(+) A-I      intronic chr1:224333463(+) A-I      intronic chr1:224333648(+) A-I      intronic chr1:224323658(+) A-I      intronic chr1:224333753(+) A-I      intronic chr1:224323657(+) A-I      intronic chr1:224333857(+) A-I      intronic chr1:224333865(+) A-I      intronic chr1:224323617(+) A-I      intronic chr1:224323572(+) A-I      intronic chr1:224323561(+) A-I      intronic chr1:224323551(+) A-I      intronic chr1:224323522(+) A-I      intronic chr1:224321465(+) A-I      intronic chr1:224321398(+) A-I      intronic chr1:224321359(+) A-I      intronic chr1:224321346(+) A-I      intronic chr1:224321320(+) A-I      intronic chr1:224321319(+) A-I      intronic chr1:224321269(+) A-I      intronic chr1:224321238(+) A-I      intronic chr1:224315433(+) A-I      intronic chr1:224334286(+) A-I      intronic chr1:224312639(+) A-I      intronic chr1:224312613(+) A-I      intronic chr1:224312559(+) A-I      intronic chr1:224312556(+) A-I      intronic chr1:224311625(+) A-I      intronic chr1:224311601(+) A-I      intronic chr1:224311533(+) A-I      intronic chr1:224309687(+) A-I      intronic chr1:224309678(+) A-I      intronic chr1:224309675(+) A-I      intronic chr1:224304771(+) A-I      intronic chr1:224334341(+) A-I      intronic chr1:224309652(+) A-I      intronic chr1:224334869(+) A-I      intronic chr1:224334872(+) A-I      intronic chr1:224334907(+) A-I      intronic chr1:224309589(+) A-I      intronic chr1:224337183(+) A-I      intronic chr1:224334916(+) A-I      intronic chr1:224334978(+) A-I      intronic chr1:224308520(+) A-I      intronic chr1:224308506(+) A-I      intronic chr1:224332204(+) A-I      intronic chr1:224308477(+) A-I      intronic chr1:224308409(+) A-I      intronic chr1:224308336(+) A-I      intronic chr1:224308310(+) A-I      intronic chr1:224306981(+) A-I      intronic chr1:224343049(+) A-I      intronic chr1:224337077(+) A-I      intronic chr1:224343009(+) A-I      intronic chr1:224343007(+) A-I      intronic chr1:224326468(+) A-I      intronic chr1:224326466(+) A-I      intronic chr1:224325862(+) A-I      intronic chr1:224325828(+) A-I      intronic chr1:224325823(+) A-I      intronic chr1:224325819(+) A-I      intronic chr1:224325809(+) A-I      intronic chr1:224325807(+) A-I      intronic chr1:224330024(+) A-I      intronic chr1:224325803(+) A-I      intronic chr1:224324307(+) A-I      intronic chr1:224325754(+) A-I      intronic chr1:224325675(+) A-I      intronic chr1:224325674(+) A-I      intronic chr1:224325131(+) A-I      intronic chr1:224325123(+) A-I      intronic chr1:224325121(+) A-I      intronic chr1:224325118(+) A-I      intronic chr1:224325104(+) A-I      intronic chr1:224325078(+) A-I      intronic chr1:224326584(+) A-I      intronic chr1:224337060(+) A-I      intronic chr1:224307046(+) A-I      intronic chr1:224329639(+) A-I      intronic chr1:224326613(+) A-I      intronic chr1:224324583(+) A-I      intronic chr1:224304676(+) A-I      intronic chr1:224308445(+) A-I      intronic chr1:224334612(+) A-I      intronic chr1:224325114(+) A-I      intronic chr1:224315448(+) A-I      intronic chr1:224324157(+) A-I      intronic chr1:224337090(+) A-I      intronic chr1:224328528(+) A-I      intronic chr1:224329933(+) A-I      intronic chr1:224327258(+) A-I      intronic chr1:224324971(+) A-I      intronic chr1:224305009(+) A-I      intronic chr1:224304738(+) A-I      intronic chr1:224328527(+) A-I      intronic chr1:224312523(+) A-I      intronic chr1:224342194(+) A-I      intronic chr1:224321349(+) A-I      intronic chr1:224305050(+) A-I      intronic chr1:224323875(+) A-I      intronic chr1:224337092(+) A-I      intronic chr1:224305881(+) A-I      intronic chr1:224312569(+) A-I      intronic chr1:224304732(+) A-I      intronic chr1:224324580(+) A-I      intronic chr1:224340371(+) A-I      intronic chr1:224333829(+) A-I      intronic chr1:224326517(+) A-I      intronic chr1:224307050(+) A-I      intronic chr1:224326692(+) A-I      intronic chr1:224326510(+) A-I      intronic chr1:224342389(+) A-I      intronic chr1:224304675(+) A-I      intronic chr1:224312447(+) A-I      intronic chr1:224327169(+) A-I      intronic chr1:224324972(+) A-I      intronic chr1:224326623(+) A-I      intronic chr1:224324579(+) A-I      intronic chr1:224324184(+) A-I      intronic chr1:224329684(+) A-I      intronic chr1:224334995(+) A-I      intronic chr1:224329641(+) A-I      intronic chr1:224320317(+) A-I      intronic chr1:224329960(+) A-I      intronic chr1:224324518(+) A-I      intronic chr1:224333356(+) A-I      intronic chr1:224304999(+) A-I      intronic chr1:224337059(+) A-I      intronic chr1:224337127(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FBXO28	chr1:224326516(+) A-I intron -    21960545 chr1:224329670(+) A-I intron -    21960545 chr1:224337083(+) A-I intron -    21960545 chr1:224337092(+) A-I intron -    21960545 chr1:224337173(+) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FBXO28	chr1:224301997-224301998(+) m6A CDS//exon       - chr1:224302012-224302013(+) m6A CDS//exon       - chr1:224340957-224340958(+) Y 3'UTR//CDS//intron       26075521 chr1:224341019-224341020(+) m6A 3'UTR//CDS//intron       24284625 chr1:224345060-224345061(+) m6A 3'UTR//CDS       24284625//24981863//22575960//22608085 chr1:224345114-224345115(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:224345129-224345130(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:224345148-224345149(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:224345213-224345214(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:224345222-224345223(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:224345233-224345234(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:224345239-224345240(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:224345246-224345247(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:224345259-224345260(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:224345276-224345277(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:224345309-224345310(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:224345407-224345408(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:224345478-224345479(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:224345560-224345561(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:224345571-224345572(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:224345577-224345578(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:224345592-224345593(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:224345620-224345621(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:224345668-224345669(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22575960//22608085 chr1:224345775-224345776(+) m6A 3'UTR       22608085 chr1:224345790-224345791(+) m6A 3'UTR       22608085 chr1:224345841-224345842(+) m6A 3'UTR       22608085 chr1:224345858-224345859(+) m6A 3'UTR       22608085 chr1:224345975-224345976(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr1:224346034-224346035(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr1:224346048-224346049(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr1:224346173-224346174(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	FBXO28	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: FBXO28

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).