Basic Information:

  VIRBase ID:  

HHID00016494

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          GABARAPL2:  NM_007285     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	GABARAPL2
miRBase Accession/Entrez ID	MIMAT0019058	11345
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ATG8//ATG8C//GATE-16//GATE16//GEF-2//GEF2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GABARAPL2	chr16:75609571(+) A-I      intronic chr16:75608875(+) A-I      intronic chr16:75608871(+) A-I      intronic chr16:75608833(+) A-I      intronic chr16:75608816(+) A-I      intronic chr16:75608800(+) A-I      intronic chr16:75605047(+) A-I      intronic chr16:75605603(+) A-I      intronic chr16:75608788(+) A-I      intronic chr16:75608722(+) A-I      intronic chr16:75608713(+) A-I      intronic chr16:75606015(+) A-I      intronic chr16:75605761(+) A-I      intronic chr16:75605675(+) A-I      intronic chr16:75609610(+) A-I      intronic chr16:75605589(+) A-I      intronic chr16:75608820(+) A-I      intronic chr16:75609333(+) A-I      intronic chr16:75604165(+) A-I      intronic chr16:75608737(+) A-I      intronic chr16:75605639(+) A-I      intronic chr16:75609664(+) A-I      intronic chr16:75608693(+) A-I      intronic chr16:75608745(+) A-I      intronic chr16:75608851(+) A-I      intronic chr16:75604106(+) A-I      intronic chr16:75605981(+) A-I      intronic chr16:75609556(+) A-I      intronic chr16:75605587(+) A-I      intronic chr16:75608736(+) A-I      intronic chr16:75605972(+) A-I      intronic chr16:75609623(+) A-I      intronic chr16:75606049(+) A-I      intronic chr16:75609572(+) A-I      intronic chr16:75605644(+) A-I      intronic chr16:75609311(+) A-I      intronic chr16:75609487(+) A-I      intronic chr16:75606009(+) A-I      intronic chr16:75609250(+) A-I      intronic chr16:75605713(+) A-I      intronic chr16:75608832(+) A-I      intronic chr16:75609533(+) A-I      intronic chr16:75609477(+) A-I      intronic chr16:75609667(+) A-I      intronic chr16:75609293(+) A-I      intronic chr16:75609323(+) A-I      intronic chr16:75606010(+) A-I      intronic chr16:75605668(+) A-I      intronic chr16:75605655(+) A-I      intronic chr16:75608945(+) A-I      intronic chr16:75608784(+) A-I      intronic chr16:75605110(+) A-I      intronic chr16:75605703(+) A-I      intronic chr16:75604063(+) A-I      intronic chr16:75609292(+) A-I      intronic chr16:75608810(+) A-I      intronic chr16:75608876(+) A-I      intronic chr16:75608811(+) A-I      intronic chr16:75609530(+) A-I      intronic chr16:75608852(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GABARAPL2	chr16:75608876(+) A-I intron -    22327324 chr16:75605587(+) A-G intron -    22484847 chr16:75608692(+) C-G intron -    22484847 chr16:75608693(+) A-G intron -    22484847 chr16:75608810(+) A-G intron -    22484847 chr16:75608851(+) A-G intron -    22484847 chr16:75608876(+) A-G intron -    22484847 chr16:75609250(+) A-G intron -    22484847 chr16:75609530(+) A-G intron -    22484847 chr16:75609556(+) A-G intron -    22484847 chr16:75609623(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GABARAPL2	chr16:75600406-75600407(+) m6A CDS       24981863 chr16:75600617-75600618(+) m6A 5'UTR//intron       - chr16:75600622-75600623(+) m6A 5'UTR//intron       - chr16:75600645-75600646(+) m6A 5'UTR//intron       - chr16:75611663-75611664(+) m6A 3'UTR//exon       27773535 chr16:75611705-75611706(+) m6A 3'UTR//exon       27773535 chr16:75611733-75611734(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	GABARAPL2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: GABARAPL2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).