Detail Information

Basic Information:


  VIRBase ID:  

HHID00016483

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:           GLIPR1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4521 GLIPR1
miRBase
Accession/Entrez ID		 MIMAT0019058 11010
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CRISP7//GLIPR//RTVP1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4521
rs1011991709 chr17:8186962    G/A
rs1011991709 chr17:8186962    G/C
rs1041768648 chr17:8186965    C/T
rs1056190393 chr17:8186959    C/A
rs1231036635 chr17:8186958    T/A
rs1231036635 chr17:8186958    T/G
rs1316923680 chr17:8186964    G/A
rs1316923680 chr17:8186964    G/C
rs1316923680 chr17:8186964    G/T
rs1365122718 chr17:8186957    G/C
rs559116584 chr17:8186963    T/C
rs559116584 chr17:8186963    T/G
rs561824123 chr17:8186969    G/A
rs768576971 chr17:8186966    T/A
rs768576971 chr17:8186966    T/C
rs776348878 chr17:8186967    C/A
rs893173803 chr17:8186960    C/G
rs893173803 chr17:8186960    C/T
rs999343007 chr17:8186968    A/G
rs1310598293 chr17:8186951    A/G
rs928871091 chr17:8186953    G/A
rs928871091 chr17:8186953    G/C
rs937623219 chr17:8186954    G/A
rs953552065 chr17:8186949    C/A
rs953552065 chr17:8186949    C/G
rs953552065 chr17:8186949    C/T
rs962385560 chr17:8186955    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR GLIPR1
chr12:75882147(+) A-I      intronic
chr12:75882136(+) A-I      intronic
chr12:75889883(+) A-I      intronic
chr12:75890055(+) A-I      intronic
chr12:75890024(+) A-I      intronic
chr12:75886045(+) A-I      intronic
chr12:75889832(+) A-I      intronic
chr12:75889853(+) A-I      intronic
chr12:75889839(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED GLIPR1
chr12:75890052(+) A-I intron -    22327324
chr12:75889814(+) T-C intron -    22484847
chr12:75889880(+) T-C intron -    22484847
chr12:75889881(+) T-C intron -    22484847
chr12:75890052(+) T-C intron -    22484847
chr12:75890053(+) T-C intron -    22484847
chr12:75890088(+) T-C intron -    22484847
chr12:75890091(+) T-C intron -    22484847
chr12:75890097(+) T-C intron -    22484847
chr12:75890121(+) T-C intron -    22484847
chr12:75889832(+) A-G intron -    22484847
chr12:75889839(+) A-G intron -    22484847
chr12:75889853(+) A-G intron -    22484847
chr12:75889883(+) A-G intron -    22484847
chr12:75889912(+) T-C intron -    22484847
chr12:75890024(+) A-G intron -    22484847
chr12:75890055(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GLIPR1
chr12:75874462-75874463(+) m6A 5'UTR       24981863
chr12:75874495-75874496(+) m6A 5'UTR       24981863
chr12:75874509-75874510(+) m6A 5'UTR       24981863
chr12:75874520-75874521(+) m6A 5'UTR       24981863
chr12:75874609-75874610(+) m6A 5'UTR       24981863
chr12:75874625-75874626(+) m6A 5'UTR       24981863
chr12:75874653-75874654(+) m6A 5'UTR       24981863
chr12:75875713-75875714(+) m6A 5'UTR//CDS       24981863
chr12:75875734-75875735(+) m6A 5'UTR//CDS       24981863
chr12:75875742-75875743(+) m6A 5'UTR//CDS       24981863
chr12:75875785-75875786(+) m6A 5'UTR//CDS       24981863
chr12:75875806-75875807(+) m6A CDS       24981863
chr12:75875820-75875821(+) m6A CDS       24981863
chr12:75893298-75893299(+) m6A 3'UTR       27773535
chr12:75893313-75893314(+) m6A 3'UTR       27773535
chr12:75893339-75893340(+) m6A 3'UTR       27773535
chr12:75893385-75893386(+) m6A 3'UTR       27773535
chr12:75893449-75893450(+) m6A 3'UTR       24981863//27773535
chr12:75893463-75893464(+) m6A 3'UTR       24981863//27773535//22608085
chr12:75893735-75893736(+) m6A 3'UTR       24981863//27773535//27371828//22608085
chr12:75893784-75893785(+) m6A 3'UTR       27773535//27371828//22608085
chr12:75894381-75894382(+) m6A 3'UTR       24981863
chr12:75894451-75894452(+) m6A 3'UTR       24981863
chr12:75894543-75894544(+) m6A 3'UTR       24981863
chr12:75894550-75894551(+) m6A 3'UTR       24981863
chr12:75895399-75895400(+) m6A 3'UTR       27773535
chr12:75895438-75895439(+) m6A 3'UTR       27773535
chr12:75895477-75895478(+) m6A 3'UTR       27773535//22608085
chr12:75895663-75895664(+) m6A 3'UTR       24981863//27773535//22608085
chr12:75895686-75895687(+) m6A 3'UTR       24981863//27773535//22608085
chr12:75895868-75895869(+) m6A 3'UTR       27773535//22608085
chr12:75896049-75896050(+) m6A 3'UTR       24981863
chr12:75896096-75896097(+) m6A 3'UTR       24981863
chr12:75896145-75896146(+) m6A 3'UTR       24981863
chr12:75896154-75896155(+) m6A 3'UTR       24981863
chr12:75896238-75896239(+) m6A 3'UTR       24981863
chr12:75896751-75896752(+) m6A 3'UTR       24981863
chr12:75896867-75896868(+) m6A 3'UTR       24981863
chr12:75896878-75896879(+) m6A 3'UTR       24981863
chr12:75896902-75896903(+) m6A 3'UTR       24981863
chr12:75896935-75896936(+) m6A 3'UTR       24981863
chr12:75896958-75896959(+) m6A 3'UTR       24981863
chr12:75897021-75897022(+) m6A 3'UTR       24981863
chr12:75897143-75897144(+) m6A 3'UTR       24981863
chr12:75897180-75897181(+) m6A 3'UTR       24981863//27773535
chr12:75897208-75897209(+) m6A 3'UTR       24981863//27773535
chr12:75897224-75897225(+) m6A 3'UTR       24981863//27773535
chr12:75897235-75897236(+) m6A 3'UTR       24981863//27773535
chr12:75897269-75897270(+) m6A 3'UTR       24981863//27773535
chr12:75897338-75897339(+) m6A 3'UTR       24981863
chr12:75897344-75897345(+) m6A 3'UTR       24981863
chr12:75897403-75897404(+) m6A 3'UTR       24981863
chr12:75897412-75897413(+) m6A 3'UTR       24981863
chr12:75897427-75897428(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4521
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
GLIPR1
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4521
Interactor2: GLIPR1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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