Detail Information

Basic Information:


  VIRBase ID:  

HHID00016468

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:           ZBTB18:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4521 ZBTB18
miRBase
Accession/Entrez ID
MIMAT0019058 10472
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C2H2-171//MRD22//RP58//TAZ-1//ZNF238

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4521
rs1011991709 chr17:8186962    G/A
rs1011991709 chr17:8186962    G/C
rs1041768648 chr17:8186965    C/T
rs1056190393 chr17:8186959    C/A
rs1231036635 chr17:8186958    T/A
rs1231036635 chr17:8186958    T/G
rs1316923680 chr17:8186964    G/A
rs1316923680 chr17:8186964    G/C
rs1316923680 chr17:8186964    G/T
rs1365122718 chr17:8186957    G/C
rs559116584 chr17:8186963    T/C
rs559116584 chr17:8186963    T/G
rs561824123 chr17:8186969    G/A
rs768576971 chr17:8186966    T/A
rs768576971 chr17:8186966    T/C
rs776348878 chr17:8186967    C/A
rs893173803 chr17:8186960    C/G
rs893173803 chr17:8186960    C/T
rs999343007 chr17:8186968    A/G
rs1310598293 chr17:8186951    A/G
rs928871091 chr17:8186953    G/A
rs928871091 chr17:8186953    G/C
rs937623219 chr17:8186954    G/A
rs953552065 chr17:8186949    C/A
rs953552065 chr17:8186949    C/G
rs953552065 chr17:8186949    C/T
rs962385560 chr17:8186955    A/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZBTB18
chr1:244214705-244214706(+) m6A 5'UTR//intron       24284625//24981863
chr1:244214719-244214720(+) m6A 5'UTR//intron       24284625//24981863
chr1:244217098-244217099(+) m6A 5'UTR//CDS       24284625//25456834//24981863//22575960//22608085
chr1:244217116-244217117(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr1:244217126-244217127(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr1:244217156-244217157(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr1:244217266-244217267(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:244217275-244217276(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:244217284-244217285(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:244217299-244217300(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:244217360-244217361(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr1:244217374-244217375(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr1:244217479-244217480(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr1:244217518-244217519(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr1:244217605-244217606(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr1:244217626-244217627(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr1:244217647-244217648(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr1:244217671-244217672(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr1:244217733-244217734(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr1:244217824-244217825(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr1:244217866-244217867(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr1:244217981-244217982(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr1:244218061-244218062(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr1:244218082-244218083(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr1:244218091-244218092(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr1:244218354-244218355(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr1:244218393-244218394(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:244218541-244218542(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:244218551-244218552(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:244218583-244218584(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:244218631-244218632(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr1:244218636-244218637(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr1:244218659-244218660(+) m6A CDS       24284625//25456834//24981863//22608085
chr1:244219179-244219180(+) m6A 3'UTR       22608085
chr1:244219197-244219198(+) m6A 3'UTR       25456834//24981863//22608085
chr1:244219272-244219273(+) m6A 3'UTR       25456834//24981863//22608085
chr1:244219333-244219334(+) m6A 3'UTR       25456834//24981863//22608085
chr1:244220008-244220009(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22608085
chr1:244220033-244220034(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085
chr1:244220038-244220039(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085
chr1:244220073-244220074(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085
chr1:244220338-244220339(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4521
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
ZBTB18
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4521
Interactor2: ZBTB18

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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