Basic Information:

  VIRBase ID:  

HHID00016465

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          OLFM1:  NM_014279     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	OLFM1
miRBase Accession/Entrez ID	MIMAT0019058	10439
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AMY//NOE1//NOELIN1//OlfA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	OLFM1	chr9:138000224(+) A-I      intronic chr9:138003620(+) A-I      intronic chr9:138006208(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OLFM1	chr9:137967362-137967363(+) m6A 5'UTR       24981863 chr9:137967450-137967451(+) m6A 5'UTR       24209618 chr9:137967580-137967581(+) m6A CDS       24284625//24209618 chr9:137967638-137967639(+) m6A CDS       25456834 chr9:137979853-137979854(+) Am CDS//intron       - chr9:137979971-137979972(+) m6A CDS//intron       24284625 chr9:137982092-137982093(+) m6A 5'UTR//CDS       24284625 chr9:137982136-137982137(+) m6A 5'UTR//CDS       24284625 chr9:137982165-137982166(+) m6A CDS       24284625 chr9:137986916-137986917(+) m6A 5'UTR//intron       24284625 chr9:137986978-137986979(+) m6A 5'UTR//intron       24284625 chr9:137987010-137987011(+) m6A 5'UTR//intron       24284625 chr9:137987743-137987744(+) m6A CDS       24981863 chr9:137987751-137987752(+) m6A CDS       24981863 chr9:137987761-137987762(+) m6A CDS       24981863 chr9:137987820-137987821(+) Cm CDS       - chr9:137989668-137989669(+) m1A 3'UTR//intron       26863196 chr9:137990172-137990173(+) Tm CDS       - chr9:137990292-137990293(+) m6A CDS       24284625 chr9:137990346-137990347(+) m6A CDS       24284625 chr9:137996015-137996016(+) Am intron       - chr9:137997519-137997520(+) m6A exon//intron       24284625 chr9:137997559-137997560(+) m6A exon//intron       24284625 chr9:137997594-137997595(+) m6A exon//intron       24284625 chr9:137997612-137997613(+) m6A exon//intron       24284625 chr9:137998638-137998639(+) m6A CDS//exon//intron       24284625 chr9:137998672-137998673(+) m6A CDS//exon//intron       24284625 chr9:138011419-138011420(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr9:138011425-138011426(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr9:138011544-138011545(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//22575960 chr9:138011550-138011551(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//22575960 chr9:138011562-138011563(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//22575960 chr9:138011575-138011576(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//22575960 chr9:138011626-138011627(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//22575960 chr9:138011713-138011714(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//22575960 chr9:138011730-138011731(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//22575960 chr9:138011739-138011740(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//22575960 chr9:138011746-138011747(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//22575960 chr9:138011853-138011854(+) m6A CDS//exon       24284625//24981863//22575960 chr9:138011896-138011897(+) m6A CDS//exon       24284625//24981863 chr9:138011923-138011924(+) m6A CDS//exon       24284625//24209618//25456834//24981863 chr9:138011938-138011939(+) m6A CDS//exon       24284625//24209618//25456834//24981863 chr9:138011959-138011960(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960 chr9:138012070-138012071(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960 chr9:138012081-138012082(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960 chr9:138012220-138012221(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960 chr9:138012241-138012242(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960 chr9:138012295-138012296(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960 chr9:138012350-138012351(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960 chr9:138012372-138012373(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960 chr9:138012381-138012382(+) Tm 3'UTR//exon       - chr9:138012544-138012545(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960 chr9:138012616-138012617(+) m6A 3'UTR//exon       24284625//24981863 chr9:138012934-138012935(+) Cm 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	OLFM1	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: OLFM1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).