Basic Information:

  VIRBase ID:  

HHID00016446

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          ARPC5:  NM_001270439     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	ARPC5
miRBase Accession/Entrez ID	MIMAT0019058	10092
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARC16//dJ127C7.3//p16-Arc

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARPC5	chr1:183596201-183596202(-) m6A 3'UTR//exon//intron       26404942 chr1:183596206-183596207(-) m6A 3'UTR//exon//intron       26404942 chr1:183596230-183596231(-) m6A 3'UTR//exon//intron       26404942 chr1:183596607-183596608(-) m6A 3'UTR//exon//intron       24284625//24981863//26404942//27371828//22575960//22608085 chr1:183596613-183596614(-) m6A 3'UTR//exon//intron       24284625//24981863//26404942//27371828//22575960//22608085 chr1:183596674-183596675(-) m6A CDS//exon//intron       24284625//24981863//26404942//27371828//22575960//22608085 chr1:183599692-183599693(-) m6A CDS//exon       26404942 chr1:183599770-183599771(-) m6A CDS//exon       27773536//22575960 chr1:183599823-183599824(-) m6A exon//intron       27773536//22575960 chr1:183599840-183599841(-) m6A exon//intron       27773536 chr1:183599915-183599916(-) m6A exon//intron       - chr1:183599952-183599953(-) m6A exon//intron       27773535 chr1:183599961-183599962(-) m6A exon//intron       27773535 chr1:183600079-183600080(-) m6A exon//intron       27773535 chr1:183600118-183600119(-) m6A exon//intron       27773535 chr1:183602204-183602205(-) m6A exon//intron       24209618//25456834//24981863//27371828//27773536 chr1:183602250-183602251(-) m6A CDS//exon       24209618//25456834//24981863//27371828//27773536 chr1:183602283-183602284(-) m6A CDS//exon       24209618//25456834//24981863//27371828//27773536 chr1:183602351-183602352(-) m6A exon//intron       24209618//25456834//24981863//27371828//27773536 chr1:183602401-183602402(-) m6A exon//intron       24209618//25456834//24981863//27371828//27773536 chr1:183602428-183602429(-) m6A exon//intron       25456834//27773536 chr1:183603045-183603046(-) m6A exon//intron       24209618//25456834//24981863 chr1:183603053-183603054(-) m6A exon//intron       24209618//25456834//24981863 chr1:183603087-183603088(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr1:183604666-183604667(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr1:183604711-183604712(-) m1A CDS       26863196//26863410 chr1:183604729-183604730(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:183604783-183604784(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	ARPC5	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: ARPC5

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).