Detail Information

Basic Information:


  VIRBase ID:  

HHID00016436

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:           ZEB2:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4521 ZEB2
miRBase
Accession/Entrez ID		 MIMAT0019058 9839
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HSPC082//SIP-1//SIP1//SMADIP1//ZFHX1B

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4521
rs1011991709 chr17:8186962    G/A
rs1011991709 chr17:8186962    G/C
rs1041768648 chr17:8186965    C/T
rs1056190393 chr17:8186959    C/A
rs1231036635 chr17:8186958    T/A
rs1231036635 chr17:8186958    T/G
rs1316923680 chr17:8186964    G/A
rs1316923680 chr17:8186964    G/C
rs1316923680 chr17:8186964    G/T
rs1365122718 chr17:8186957    G/C
rs559116584 chr17:8186963    T/C
rs559116584 chr17:8186963    T/G
rs561824123 chr17:8186969    G/A
rs768576971 chr17:8186966    T/A
rs768576971 chr17:8186966    T/C
rs776348878 chr17:8186967    C/A
rs893173803 chr17:8186960    C/G
rs893173803 chr17:8186960    C/T
rs999343007 chr17:8186968    A/G
rs1310598293 chr17:8186951    A/G
rs928871091 chr17:8186953    G/A
rs928871091 chr17:8186953    G/C
rs937623219 chr17:8186954    G/A
rs953552065 chr17:8186949    C/A
rs953552065 chr17:8186949    C/G
rs953552065 chr17:8186949    C/T
rs962385560 chr17:8186955    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZEB2
chr2:145193071(-) A-I      intronic
chr2:145193080(-) A-I      intronic
chr2:145193082(-) A-I      intronic
chr2:145193083(-) A-I      intronic
chr2:145193088(-) A-I      intronic
chr2:145193089(-) A-I      intronic
chr2:145193097(-) A-I      intronic
chr2:145193106(-) A-I      intronic
chr2:145193109(-) A-I      intronic
chr2:145193114(-) A-I      intronic
chr2:145167590(-) A-I      intronic
chr2:145167434(-) A-I      intronic
chr2:145167617(-) A-I      intronic
chr2:145155215(-) A-I      intronic
chr2:145180155(-) A-I      intronic
chr2:145167361(-) A-I      intronic
chr2:145152671(-) A-I      intronic
chr2:145167422(-) A-I      intronic
chr2:145243413(-) A-I      intronic
chr2:145121745(-) A-I      intronic
chr2:145167341(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZEB2
chr2:145146775-145146776(-) m6A 3'UTR//intron       24981863
chr2:145146791-145146792(-) m6A 3'UTR//intron       24981863
chr2:145146833-145146834(-) m6A 3'UTR//intron       24981863//22608085
chr2:145146871-145146872(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr2:145146894-145146895(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr2:145146955-145146956(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr2:145147013-145147014(-) m6A 3'UTR//intron       24284625//24981863//27773535//27371828//22608085
chr2:145147039-145147040(-) m6A CDS//intron       24284625//24981863//27773535//27371828//22608085
chr2:145147051-145147052(-) m6A CDS//intron       24284625//24981863//27371828//22608085
chr2:145147061-145147062(-) m6A CDS//intron       24284625//24981863//27371828//22608085
chr2:145147109-145147110(-) m6A CDS//intron       24284625//24981863//27371828//22608085
chr2:145147114-145147115(-) m1A CDS//intron       26863196
chr2:145147203-145147204(-) m6A CDS//intron       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr2:145147336-145147337(-) m6A CDS//intron       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr2:145147356-145147357(-) m6A CDS//intron       24284625//25456834//24981863//27371828//27773536//22608085
chr2:145147551-145147552(-) m6A CDS//intron       24981863//27773535
chr2:145147587-145147588(-) m6A CDS//intron       24981863//27773535
chr2:145153985-145153986(-) m6A CDS//intron       24981863//27773535
chr2:145154026-145154027(-) m6A CDS//intron       24981863//27773535
chr2:145154065-145154066(-) m6A CDS//intron       24981863
chr2:145156010-145156011(-) m6A CDS//intron       24981863
chr2:145156077-145156078(-) m6A CDS//intron       24284625//24981863//22608085
chr2:145156093-145156094(-) m6A CDS//intron       24284625//24981863//22608085
chr2:145156126-145156127(-) m6A CDS//intron       24284625//24981863//22608085
chr2:145156171-145156172(-) m6A CDS//intron       24981863//22608085
chr2:145156189-145156190(-) m6A CDS//intron       24981863//22608085
chr2:145156244-145156245(-) m6A CDS//intron       24981863//22608085
chr2:145156249-145156250(-) m6A CDS//intron       24981863//22608085
chr2:145156275-145156276(-) m6A CDS//intron       24981863//22608085
chr2:145156287-145156288(-) m6A CDS//intron       24981863//22608085
chr2:145156303-145156304(-) m6A CDS//intron       24981863//22608085
chr2:145156342-145156343(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr2:145156369-145156370(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr2:145156426-145156427(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr2:145156443-145156444(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr2:145156467-145156468(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr2:145156515-145156516(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr2:145156543-145156544(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr2:145156551-145156552(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr2:145156579-145156580(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr2:145156674-145156675(-) m6A CDS//intron       24284625//24981863//27773535//27371828//22608085
chr2:145156734-145156735(-) m6A CDS//intron       24284625//24981863//22608085
chr2:145156756-145156757(-) m6A CDS//intron       24284625//24981863//22608085
chr2:145156792-145156793(-) m6A CDS//intron       24284625//24981863//22608085
chr2:145156897-145156898(-) m6A CDS//intron       22608085
chr2:145157032-145157033(-) m6A CDS//intron       24981863//22608085
chr2:145157106-145157107(-) m6A CDS//intron       24981863//22608085
chr2:145157253-145157254(-) m6A CDS//intron       24981863//22608085
chr2:145157323-145157324(-) m6A CDS//intron       24981863//22608085
chr2:145157350-145157351(-) m6A CDS//intron       24981863//22608085
chr2:145157566-145157567(-) m6A CDS//intron       24284625//24981863//22608085
chr2:145157574-145157575(-) m6A CDS//intron       24284625//24981863//22608085
chr2:145157579-145157580(-) m6A CDS//intron       24284625//24981863//22608085
chr2:145157600-145157601(-) m6A CDS//intron       -
chr2:145157604-145157605(-) m6A CDS//intron       24284625//24981863//22608085
chr2:145157622-145157623(-) m6A CDS//intron       24284625//24981863//22608085
chr2:145157641-145157642(-) m6A CDS//intron       24981863//22608085
chr2:145161570-145161571(-) m6A CDS//exon       -
chr2:145161682-145161683(-) m6A CDS//exon       -
chr2:145182418-145182419(-) m6A CDS//exon//intron       27371828
chr2:145187541-145187542(-) m6A 3'UTR//CDS//exon       24981863
chr2:145187553-145187554(-) Cm 3'UTR//CDS//exon       -
chr2:145187554-145187555(-) m6A 3'UTR//CDS//exon       24981863
chr2:145187568-145187569(-) m6A 3'UTR//CDS//exon       24981863
chr2:145187586-145187587(-) m6A 3'UTR//CDS//exon       24981863
chr2:145276000-145276001(-) m6A 5'UTR//intron       -
chr2:145277513-145277514(-) m6A 5'UTR//exon//intron       -
chr2:145277518-145277519(-) m6A 5'UTR//exon//intron       -
chr2:145277525-145277526(-) m6A 5'UTR//exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4521
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
ZEB2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4521
Interactor2: ZEB2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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